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Minimally invasive video-assisted subtotal parathyroidectomy with thymectomy for secondary hyperparathyroidism

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Abstract

Background

Secondary hyperparathyroidism (sHPT) is common in patients with chronic renal failure. Bilateral cervical exploration is optimal for patients with sHPT. The aims of this clinical trial are to evaluate the feasibility of video-assisted subtotal parathyroidectomy as an alternative surgical treatment for sHPT.

Methods

This prospective study included 12 consecutive patients with sHPT. Surgical indications included a high intact parathormone level, enlarged parathyroid glands, high bone turnover and conditions refractory to medical treatment of hypercalcemia and hyperphosphatemia.

Results

All patients underwent minimally invasive video-assisted subtotal parathyroidectomy and trans-cervical thymectomy. Four cervical glands were found in all patients and intrathymic glands were identified in three (25%) patients.

Conclusion

Minimally invasive video-assisted subtotal parathyroidectomy offers an alternative method, and this technique can be performed safely for sHPT.

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References

  1. de Francisco AL (2004) Secondary hyperparathyroidism: review of the disease and its treatment. Clin Ther 26:1976–1993 doi:10.1016/j.clinthera.2004.12.011

    Article  PubMed  Google Scholar 

  2. de Francisco AL, Fresnedo GF, Rodrigo E, Piñera C, Amado JA, Arias M (2002) Parathyroidectomy in dialysis patients. Kidney Int Suppl 61:161–166 doi:10.1046/j.1523-1755.61.s80.27.x

    Article  Google Scholar 

  3. de Francisco AL (2008) New strategies for the treatment of hyperparathyroidism incorporating calcimimetics. Expert Opin Pharmacother 9:795–811 doi:10.1517/14656566.9.5.795

    Article  PubMed  Google Scholar 

  4. National Kidney Foundation (2003) K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 42:1–202

    Google Scholar 

  5. Richards ML, Wormuth J, Bingener J, Sirinek K (2006) Parathyroidectomy in secondary hyperparathyroidism: is there an optimal operative management? Surgery 139:174–180 doi:10.1016/j.surg.2005.08.036

    Article  PubMed  Google Scholar 

  6. Schlosser K, Endres N, Celik I, Fendrich V, Rothmund M, Fernández ED (2007) Surgical treatment of tertiary hyperparathyroidism: the choice of procedure matters!. World J Surg 31:1947–1953 doi:10.1007/s00268-007-9187-z

    Article  PubMed  Google Scholar 

  7. Sackett WR, Barraclough B, Reeve TS, Delbridge LW (2002) Worldwide trends in the surgical treatment of primary hyperparathyroidism in the era of minimally invasive parathyroidectomy. Arch Surg 137:1055–1059 doi:10.1001/archsurg.137.9.1055

    Article  PubMed  Google Scholar 

  8. Carling T, Udelsman R (2008) Focused approach to parathyroidectomy. World J Surg 32:1512–1517 doi:10.1007/s00268-008-9567-z

    Article  PubMed  Google Scholar 

  9. Miccoli P, Berti P, Materazzi G, Massi M, Picone A, Minuto MN (2004) Results of video-assisted parathyroidectomy: single institution’s six-year experience. World J Surg 28:1216–1218 doi:10.1007/s00268-004-7638-3

    Article  PubMed  Google Scholar 

  10. Sosa JA, Udelsman R (2003) Minimally invasive parathyroidectomy. Surg Oncol 12:125–134 doi:10.1016/S0960-7404(03)00041-0

    Article  PubMed  Google Scholar 

  11. Sitges-Serra A, Rosa P, Valero M, Membrilla E, Sancho JJ (2008) Surgery for sporadic primary hyperparathyroidism: controversies and evidence-based approach. Langenbecks Arch Surg 393:239–244 doi:10.1007/s00423-008-0283-9

    Article  PubMed  Google Scholar 

  12. Gasparri G, Camandona M, Abbona GC, Papotti M, Jeantet A, Radice E et al (2001) Secondary and tertiary hyperparathyroidism: causes of recurrent disease after 446 parathyroidectomies. Ann Surg 233:65–69 doi:10.1097/00000658-200101000-00011

    Article  PubMed  CAS  Google Scholar 

  13. Pattou FN, Pellissier LC, Noel C, Wambergue F, Huglo DG, Proye CA (2000) Supernumerary parathyroid glands: frequency and surgical significance in treatment of renal hyperparathyroidism. World J Surg 24:1330–1334 doi:10.1007/s002680010220

    Article  PubMed  CAS  Google Scholar 

  14. Mandl F (1926) Attempt to treat generalized fibrous osteitis by extirpation of parathyroid tumor. Zentralbl Chir 53:260–264

    Google Scholar 

  15. Miccoli P, Berti P, Materazzi G, Donatini G (2003) Minimally invasive video assisted parathyroidectomy (MIVAP). Eur J Surg Oncol 29(2):188–190 doi:10.1053/ejso.2002.1313

    Article  PubMed  CAS  Google Scholar 

  16. Miccoli P (2002) Minimally invasive surgery for thyroid and parathyroid diseases. Surg Endosc 16:3–6 doi:10.1007/s00464-001-8140-8

    Article  PubMed  CAS  Google Scholar 

  17. Miccoli P, Bendinelli C, Conte M, Pinchera A, Marcocci C (1998) Endoscopic parathyroidectomy by a gasless approach. J Laparoendosc Adv Surg Tech A 8(4):189–194

    Article  PubMed  CAS  Google Scholar 

  18. Miccoli P, Bendinelli C, Berti P, Vignali E, Pinchera A, Marcocci C (1999) Video-assisted versus conventional parathyroidectomy in primary hyperparathyroidism: a prospective randomized study. Surgery 126(6):1117–1121

    Article  PubMed  CAS  Google Scholar 

  19. Mourad M, Ngongang C, Saab N, Coche E, Jamar F, Michel JM et al (2001) Video-assisted neck exploration for primary and secondary hyperparathyroidism: initial experience. Surg Endosc 15:1112–1115

    Article  PubMed  CAS  Google Scholar 

  20. Mekel M, Mahajna A, Ish-Shalom S, Barak M, Segal E, Salih AA et al (2005) Minimally invasive surgery for treatment of hyperparathyroidism. Isr Med Assoc J. 7:323–327

    PubMed  Google Scholar 

  21. Miccoli P, Berti P, Materazzi G, Ambrosini CE, Fregoli L, Donatini G (2008) Endoscopic bilateral neck exploration versus quick intraoperative parathormone assay (qPTHa) during endoscopic parathyroidectomy: A prospective randomized trial. Surg Endosc 22:398–400

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Yeşim Erbil.

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Barbaros, U., Erbil, Y., Yıldırım, A. et al. Minimally invasive video-assisted subtotal parathyroidectomy with thymectomy for secondary hyperparathyroidism. Langenbecks Arch Surg 394, 451–455 (2009). https://doi.org/10.1007/s00423-008-0413-4

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  • DOI: https://doi.org/10.1007/s00423-008-0413-4

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