Abstract
Objective
Videoscopic splanchnicectomy (VSPL) is a method of pain relief in chronic pancreatitis patients. Because this method is not equally effective in all patients, this study was designed to identify the factors determining the unfavorable results of VSPL.
Materials and methods
This is a non-randomized prospective case-controlled study designed to compare a group of patients suffering from chronic pancreatitis treated with VSPL (N = 48) versus a group of patients treated symptomatically (N = 42). The outcome was measured as the intensity of pain ailments [visual analog scale (VAS)-pain scale] and subjective satisfaction of the patients from the surgical treatment [Functional Assessment of Chronic Illness Therapy-Treatment Satisfaction (FACIT-TS)]. The predictive variables considered in this study were: age, sex, emotional status, social support (the two last variables were measured by subscales of quality-of-life questionnaire from the group of FACIT), history of previous surgical treatment, and opioid use for at least 3 months before VSPL. The follow-up was 18 months. Logistic regression was performed using dichotomized pain as outcome variable: high score more than 66.7 on VAS scale and low under 50 points on VAS scale 18 months after VSPL.
Results
VSPL significantly reduced the pain ailments at all points of the study when compared to the control. However, the pain intensity at the end of the study was higher than directly after the surgery. In the patients treated with opioids before the surgery, the pain intensity was significantly higher than in the patients not using this group of drugs. Logistic regression revealed that opioid administration before VSPL was the most important predictor of high pain scores 18 months after the surgery.
Conclusion
When planning the VSPL in the treatment of pain in patients suffering from chronic pancreatitis, it is necessary to take into consideration the previous chronic use of opioids, as this variable can significantly influence poorer results of this surgical pain management.
Similar content being viewed by others
References
Saenz A, Kuriansky J, Salvador L, Astudillo E, Cardona V, Shabtai M, Fernandez-Cruz L (2000) Thoracoscopic splanchnicectomy for pain control in patients with unresectable carcinoma of the pancreas. Surg Endosc 14(8):717–720
Stefaniak T, Basinski A, Vingerhoets A, Makarewicz W, Connor S, Kaska L, Stanek A, Kwiecinska B, Lachinski AJ, Sledzinski Z (2005) A comparison of two invasive techniques in the management of intractable pain due to inoperable pancreatic cancer: neurolytic celiac plexus block and videothoracoscopic splanchnicectomy. Eur J Surg Oncol 31(7):768–773
Bradley EL 3rd, Bem J (2003) Nerve blocks and neuroablative surgery for chronic pancreatitis. World J Surg 27(11):1241–1248
Ihse I, Zoucas E, Gyllstedt E, Lillo-Gil R, Andren-Sandberg A (1999) Bilateral thoracoscopic splanchnicectomy: effects on pancreatic pain and function. Ann Surg 230(6):785–790
Makarewicz W, Stefaniak T, Kossakowska M, Basinski A, Suchorzewski M, Stanek A, Gruca ZB (2003) Quality of life improvement after videothoracoscopic splanchnicectomy in chronic pancreatitis patients: case control study. World J Surg 27(8):906–911
Maher JW, Johlin FC, Heitshusen D (2001) Long-term follow-up of thoracoscopic splanchnicectomy for chronic pancreatitis pain. Surg Endosc 15:706–709
Makarewicz W, Stefaniak T, Stanek A, Basinski A, Kossakowska M, Gruca Z (2002) Factors determining morbidity and effectiveness in videothoracoscopic splanchnicectomy. Zentralbl Chir 127(11):950–955
Ammori BJ (2003) Pancreatic surgery in the laparoscopic era. JOP 4:187–192
Howard TJ, Swofford JB, Wagner DL et al (2002) Quality of life after bilateral thoracoscopic splanchnicectomy: long-term evaluation in patients with chronic pancreatitis. J Gastrointest Surg 6:845–852
House JS, Landis KR, Umberson D (1988) Social relationships and health. Science 241:540–545
Ballantyne J (2003) Chronic pain following treatment for cancer: role of opioids. Oncologist 8:567–575
Breivik H (2001) Opioids in cancer and chronic non-cancer pain therapy—indications and controversies. Acta Anaesthsiol Scand 45:1059–1066
Ong KS, Keng SB (2003) The biological, social, and psychological relationship between depression and chronic pain. Cranio 21(4):286–294
Stefaniak T, Vingerhoets A, Babinska D, Trus M, Glowacki J, Dymecki D, Makarewicz W, Kaska L, Kobiela J, Lachinski AJ, Stanek A, Gruca Z, Sledzinski Z, Markuszewska-Proczko M (2004) Psychological factors influencing results of cholecystectomy. Scand J Gastroenterol 39(2):127–132
Herbert RD (2005) Randomisation in clinical trials. Aust J Physiother 51(1):58–60
Webster K, Cella D, Yost K (2003) The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation. Health Qual Life Outcomes 1:79
Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, Silberman M, Yellen SB, Winicour P, Brannon J (1993) The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol 11:570–579
Stefaniak T, Makarewicz W, Kossakowska M, Basiński A, Reszetow J, Kobiela J, Stanek A, Łachiński A, Konarski R, Gruca Z (2003) Application of the FACIT questionnaire in the evaluation of the quality of life in patients with chronic pancreatitis: Polish conditions. Pol Przegl Chir 75(10):956–965
Yuan C, Foss JF, O’Connor M, Toledano A, Roizen M, Moss J (1996) Methylnaltrexone prevents morphine-induced delay in oral–cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trial. Clin Pharmacol Ther 59:469–475
Gan TJ, Ginsberg B, Glass PS, Fortney J, Jhaveri R, Perno R (1997) Opioidsparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology 87:1075–1081
Nicholson B (2003) Responsible prescribing of opioids for the management of chronic pain. Drugs 63(1):17–32
Jamison RN, Schein JR, Vallow S, Ascher S, Vorsanger GJ, Katz NP (2003) Neuropsychological effects of long-term opioid use in chronic pain patients. J Pain Symptom Manage 26(4):913–921
Martelli MF, Zasler ND, Bender MC, Nicholson K (2004) Psychological, neuropsychological, and medical considerations in assessment and management of pain. J Head Trauma Rehabil 19(1):10–28
Vallejo R, de Leon-Casasola O, Benyamin R (2004) Opioid therapy and immunosuppression: a review. Am J Ther 11(5):354–365
WHO (1990) Cancer pain relief and palliative care. World Health Organization, Technical Report Series No 804, Geneva, Switzerland
Friedman JD, Dell Buono FA (2001) Opioid antagonists in the treatment of opioid-induced constipation and pruritus. Ann Pharmacother 35:85–91
Singh VV, Toskes PP (2003) Medical therapy for chronic pancreatitis pain. Curr Gastroenterol Rep 5:110–116
Raith K, Hochhaus G (2004) Drugs used in the treatment of opioid tolerance and physical dependence: a review. Int J Clin Pharmacol Ther 42:191–203
Turk DC, Okifuji A (2002) Psychological factors in chronic pain: evolution and revolution. J Consult Clin Psychol 70(3):678–690
Hanck C, Whitcomb DC (2004) Alcoholic pancreatitis. Gastroenterol Clin North Am 33(4):751–765
Kreek MJ, Nielsen DA, LaForge KS (2004) Genes associated with addiction: alcoholism, opiate, and cocaine addiction. Neuromolecular Med 5:85–108
Finn AK, Whistler JL (2001) Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal. Neuron 32:829–839
South SM, Smith MT (2001) Analgesic tolerance to opioids. Pain Clin Updates 9:1–4
Mao J, Price DD, Mayer DJ (1995) Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 62:259–274
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Stefaniak, T., Vingerhoets, A., Makarewicz, W. et al. Opioid use determines success of videothoracoscopic splanchnicectomy in chronic pancreatic pain patients. Langenbecks Arch Surg 393, 213–218 (2008). https://doi.org/10.1007/s00423-007-0177-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00423-007-0177-2