Skip to main content

Advertisement

Log in

Predictors of long-term survival in node-positive gastric carcinoma patients with curative resection

  • Original Article
  • Published:
Langenbeck's Archives of Surgery Aims and scope Submit manuscript

Abstract

Background and aims

We analyzed the clinicopathologic features of node-positive gastric carcinoma patients who were long-term survivors (5 years or longer) and evaluated the predictive factors associated with long-term survival.

Patients and methods

Of 554 node-positive gastric carcinoma patients with curative resection, 161 (29.1%) were long-term survivors, and 393 died of the disease before 5 years.

Results

The long-term survivor group had a recurrence rate of 16.1%, while the recurrence rate was 95.4% in the short-term survivor group (P < 0.05). The mean tumor size in the long-term survivors (4.5 cm) was significantly smaller than that in the short-term survivors (5.3 cm; P < 0.001). A depth of invasion greater than T3 was found more frequently in the short-term survivor group (88.1%) than in the long-term survivor group (70.1%; P < 0.001). Using Cox’s proportional hazard regression model, the only factor found to be an independent, statistically significant prognostic parameter was tumor size (risk ratio, 0.301; 95% confidence interval, 0.10–0.88; P < 0.05).

Conclusion

The tumor size emerged as the only independent, significant factor for the prediction of long-term survival in node-positive gastric carcinoma patients with curative resection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Bozzetti F, Bonfanti G, Morabito A, Bufalino R, Menotti V, Andreola S, Doci R, Gennari L (1986) Multifactorial approach for the prognosis of patients with carcinoma of the stomach after curative resection. Surg Gynecol Obstet 162:229–234

    PubMed  CAS  Google Scholar 

  2. Maruyama K (1987) The most important prognostic factors for gastric cancer patients. Scand J Gastroenterol 22:63–68

    Google Scholar 

  3. Adachi Y, Ogawa Y, Sasaki Y, Yukaya H, Mori M, Sugimachi K (1994) A clinicopathologic study of gastric carcinoma with reference to age of patients. J Clin Gastroenterol 18:287–290

    Article  PubMed  CAS  Google Scholar 

  4. Siewert JR, Bottcher K, Stein HJ, Roder JD (1998) Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann Surg 228:449–461

    Article  PubMed  CAS  Google Scholar 

  5. Greene FL, Page DL, Fleming ID (2002) AJCC cancer staging manual, 6th ed. Springer, Berlin Heidelberg New York

    Google Scholar 

  6. Japanese Gastric Cancer Association (1998) Japanese classification of gastric carcinoma, 2nd English edn. Gastric Cancer 1:10–24

    Article  PubMed  Google Scholar 

  7. Neugut AI, Hayek M, Howe G (1996) Epidemiology of gastric cancer. Semin Oncol 28:281–291

    Google Scholar 

  8. Adachi Y, Mori M, Maehara Y, Sugimachi K (1995) Long-term survival after resection for advanced gastric carcinoma. J Clin Gastroenterol 21:208–210

    Article  PubMed  CAS  Google Scholar 

  9. Yokota T, Ishiyama S, Saito T, Teshima S, Yamada Y, Iwamoto K, Takahashi M, Murata K, Yamauchi H (2002) Is tumor size a prognostic indicator for gastric carcinoma? Anticancer Res 22:3673–3677

    PubMed  Google Scholar 

  10. Mitsudomi T, Matsusaka T, Wakasugi K, Takenaka M, Kume K, Fujinaga Y, Teraoka H, Iwashita A (1989) A clinicopathological study of gastric cancer with special reference to age of the patients: an analysis of 1,630 cases. World J Surg 13:225–230

    Article  PubMed  CAS  Google Scholar 

  11. Moriguchi S, Odaka T, Hayashi Y, Nose Y, Maehara Y, Korenaga D, Sugimachi K (1991) Death due to recurrence following curative resection of early gastric cancer depends on age of the patient. Br J Cancer 64:555–558

    PubMed  CAS  Google Scholar 

  12. Adachi Y, Mori M, Maehara Y, Kitano S, Sugimachi K (1997) Prognostic factors of node-negative gastric carcinoma: univariate and multivariate analyses. J Am Coll Surg 184:373–377

    PubMed  CAS  Google Scholar 

  13. Houry S, Amenabar J, Rezvani A, Huguier M (1994) Should patients over 80 years old be operated on for colorectal or gastric cancer? Hepatogastroenterology 41:521–525

    PubMed  CAS  Google Scholar 

  14. Takeda J, Tanaka T, Koufuji K, Kodama I, Tsuji Y, Kakegawa T (1994) Gastric cancer surgery in patients aged at least 80 years old. Hepatogastroenterology 41:516–520

    PubMed  CAS  Google Scholar 

  15. Mori M, Sugimachi K (1990) Clinicopathologic studies of gastric carcinoma. Semin Surg Oncol 6:19–27

    Article  PubMed  CAS  Google Scholar 

  16. Moriguchi S, Maehara Y, Korenaga D, Sugimachi K, Hayashi Y, Nose Y (1992) Prediction of survival time after curative surgery for advanced gastric cancer. Eur J Surg Oncol 18:287–292

    PubMed  CAS  Google Scholar 

  17. Noda S, Soejima K, Inokuchi K (1980) Clinicopathological analysis of the intestinal type and diffuse type of gastric carcinoma. Jpn J Surg 10:277–283

    Article  PubMed  CAS  Google Scholar 

  18. Nakamura K, Ueyama T, Yao T, Xuan ZX, Ambe K, Adachi Y, Yakeishi Y, Matsukuma A, Enjoji M (1992) Pathology and prognosis of gastric carcinoma. Findings in 10,000 patients who underwent primary gastrectomy. Cancer 70:1030–1037

    Article  PubMed  CAS  Google Scholar 

  19. Kim J, Cheong JH, Hyung WJ, Shen J, Choi SH, Noh SH (2004) Predictors of long-term survival in pN3 gastric cancer patients. J Surg Oncol 88:9–13

    Article  PubMed  Google Scholar 

  20. Adachi Y, Oshiro T, Mori M, Maehara Y, Sugimachi K (1997) Tumor size as a simple prognostic indicator for gastric carcinoma. Ann Surg Oncol 4:137–140

    Article  PubMed  CAS  Google Scholar 

  21. Harrison LE, Karpeh MS, Brennan MF (1998) Extended lymphadenectomy is associated with a survival benefit for node-negative gastric cancer. J Gastrointest Surg 2:126–131

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dong Yi Kim.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, D.Y., Joo, J.K., Park, Y.K. et al. Predictors of long-term survival in node-positive gastric carcinoma patients with curative resection. Langenbecks Arch Surg 392, 131–134 (2007). https://doi.org/10.1007/s00423-006-0114-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00423-006-0114-9

Keywords

Navigation