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Simultaneous segmental obstruction of bile duct and portal vein markedly changes a population of biliary and hepatic cells in human liver

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Abstract

Background and aims

No studies have investigated histologic changes caused by simultaneous segmental obstruction of the bile duct and portal vein in human liver.

Patients/Methods

Liver tissues with simultaneous obstruction of the segmental bile duct and portal vein (O+/+ liver), with segmental bile duct obstruction alone (O+/− liver), and without obstruction (O−/− liver) were obtained from patients who underwent hepatectomy, and studied morphologically and immunohistochemically.

Results

In O+/+ liver, the proportional area consisting of hepatocytes was significantly less (31.0±25.8%) than in O+/− liver (78.4±18.9%) or O−/− liver (86.5±9.2%). In contrast, the proportional area consisting of biliary epithelial cells was significantly higher in O+/+ liver (9.1±6.1%) than in O+/− liver (1.6±1.5%) or O−/− liver (0.7±0.6%). The proportional area consisting of fibrous tissue also was significantly higher in O+/+ liver than in the other two groups. In O+/+ liver, some cells located at the periphery of hepatocyte areas were immunoreactive for both hepatocyte and biliary epithelial cell markers.

Conclusion

Simultaneous segmental obstruction of the bile duct and portal vein induces a marked ductular increase, periportal fibrosis, and a reduction in the number of hepatocytes in human liver tissue.

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Authors and Affiliations

  1. First Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Syowa-ku, 466-8550, Nagoya, Japan

    Takanori Kyokane, Masato Nagino, Junichi Kamiya & Yuji Nimura

  2. Department of Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Tetsuro Nagasaka

Authors
  1. Takanori Kyokane
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  2. Masato Nagino
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  3. Junichi Kamiya
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  4. Yuji Nimura
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  5. Tetsuro Nagasaka
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Correspondence to Takanori Kyokane.

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Kyokane, T., Nagino, M., Kamiya, J. et al. Simultaneous segmental obstruction of bile duct and portal vein markedly changes a population of biliary and hepatic cells in human liver. Langenbecks Arch Surg 388, 270–275 (2003). https://doi.org/10.1007/s00423-003-0380-8

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  • DOI: https://doi.org/10.1007/s00423-003-0380-8

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