Biological Cybernetics

, Volume 112, Issue 5, pp 465–482 | Cite as

Physiology-based ERPs in normal and abnormal states

  • M S ZobaerEmail author
  • P A Robinson
  • C C Kerr
Original Article


Evoked response potentials (ERPs) and other transients are modeled as impulse responses using physiology-based neural field theory (NFT) of the corticothalamic system of neural activity in the human brain that incorporates synaptic and dendritic dynamics, firing response, axonal propagation, and corticocortical and corticothalamic pathways. The properties of model-predicted ERPs are explored throughout the stability zone of the corticothalamic system, and predicted time series and wavelet spectra are also analyzed. This provides a unified treatment of predicted ERPs for both normal and abnormal states within the brain’s stability zone, including likely parameters to represent abnormal states of reduced arousal.


Evoked response potentials Neural field theory Corticothalamic system Modeling Neurophysiology 



We thank R. Townsend for assistance with MATLAB and S. Assadzadeh for helpful discussions. This work was supported by the Australian Research Council Center of Excellence for Integrative Brain Function (ARC Center of Excellence Grant CE140100007), Australian Research Council Laureate Fellowship Grant FL140100025, and Discovery Early Career Research Award DE140101375.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of PhysicsThe University of SydneySydneyAustralia
  2. 2.Center for Integrative Brain FunctionThe University of SydneySydneyAustralia
  3. 3.Center for Research ExcellenceGlebeAustralia
  4. 4.Department of PhysicsBangladesh University of TextilesDhakaBangladesh
  5. 5.Department of Physiology and PharmacologyState University of New York Downstate Medical CenterBrooklynUSA

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