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Subthreshold activation of spinal motoneurones in the stretch reflex: experimental data and modeling

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Abstract

Responses of gastrocnemius–soleus motoneurones to stretches of the homonymous muscles were recorded intrasomatically in decerebrate cats; changes of membrane potential (MP) were evoked by smoothed trapezoid stretches of the muscles. Amplitudes of separate excitatory postsynaptic potentials (EPSPs) were defined via differences between values of MP at the end and beginning of the positive derivative waves, which were also used as basic elements in the model of the excitatory postsynaptic currents (EPSCs). EPSCs were assumed to be transformed into EPSPs by low-pass filtering properties of the somatic membrane; parameters of the filtering were firstly defined from analysis of Ia EPSP in the same cell and then were applied in model P m0. The model showed unsatisfactory quality in tracking slow components of MP; to overcome the disadvantage there was proposed model P m1 based on addition to P m0 the difference between two low-pass filtered signals MP and P m0 (the cutoff frequency 10 or 20 Hz). An overestimation of EPSPs’ amplitudes was corrected in model P m2. The mismatch in tracking slow changes of MP was assumed to be connected with summation of a great number of low-amplitude EPSPs generated at distal dendrites; information about waveform of separate EPSPs could disappear in this process. One can speculate that slow components of membrane depolarization at least partly are linked with the persistent inward currents in dendrites; variable and, sometimes, too fast decays in EPSPs seem to reflect inhibitory synaptic influences.

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Authors and Affiliations

  1. Department of Movement Physiology, A.A. Bogomoletz Institute of Physiology, National Academy of Sciences, Bogomoletz Street 4, 01024, Kiev, Ukraine

    A. I. Kostyukov, S. V. Lytvynenko, N. V. Bulgakova & A. V. Gorkovenko

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  1. A. I. Kostyukov
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  2. S. V. Lytvynenko
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  3. N. V. Bulgakova
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  4. A. V. Gorkovenko
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Correspondence to A. I. Kostyukov.

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Kostyukov, A.I., Lytvynenko, S.V., Bulgakova, N.V. et al. Subthreshold activation of spinal motoneurones in the stretch reflex: experimental data and modeling. Biol Cybern 100, 307–318 (2009). https://doi.org/10.1007/s00422-009-0303-z

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  • DOI: https://doi.org/10.1007/s00422-009-0303-z

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