Branching dendrites with resonant membrane: a “sum-over-trips” approach
- 157 Downloads
Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons. It is well known that dendritic morphology plays an important role in the function of dendrites. Another important contribution to the response characteristics of a single neuron comes from the intrinsic resonant properties of dendritic membrane. In this paper we combine the effects of dendritic branching and resonant membrane dynamics by generalising the “sum-over-trips” approach (Abbott et al. in Biol Cybernetics 66, 49–60 1991). To illustrate how this formalism can shed light on the role of architecture and resonances in determining neuronal output we consider dual recording and reconstruction data from a rat CA1 hippocampal pyramidal cell. Specifically we explore the way in which an Ih current contributes to a voltage overshoot at the soma.
KeywordsDendrites Quasi-active membrane “Sum-over-trips” Cable theory
Unable to display preview. Download preview PDF.
- Carnevale NT, Hines ML (2006) The NEURON Book. Cambridge University Press, LondonGoogle Scholar
- Scott A (2002) Neuroscience: a mathematical primer. Springer, HeidelbergGoogle Scholar
- Segev I, Rinzel J, Shepherd GM (eds) (1995) The theoretical foundations of dendritic function: selected papers of Wilfrid Rall with commentaries. MIT Press, CambridgeGoogle Scholar
- Stuart G, Spruston N, Häusser M. (eds.) (1999) Dendrites. Oxford University Press, New YorkGoogle Scholar
- Tuckwell HC (1988) Introduction to theoretical neurobiology, vol 1. Cambridge University Press, LondonGoogle Scholar