Skip to main content

Advertisement

Log in

Effect of sodium citrate on performance and metabolism of human skeletal muscle during supramaximal cycling exercise

  • ORIGINAL ARTICLE
  • Published:
European Journal of Applied Physiology and Occupational Physiology Aims and scope Submit manuscript

Abstract

The aim of this study was to examine whether the alkalosis-induced improvement in supramaximal performance could be explained by a less-altered muscle metabolic status. Eight subjects first performed exhausting exercise at 120% peak oxygen uptake after ingesting either a placebo (PLC) or sodium citrate (CIT) at a dose of 0.5 g · kg−1 body mass to determine exhaustion time (t exh). They then, performed exercise (Lim-EX) at the same relative intensity lasting PLCt exh minus 20 s in both treatments. Samples were taken from vastus lateralis muscle at rest (90-min after the ingestion) and at the end of Lim-EX. Arterial blood samples were obtained at rest (immediately prior to and 90 min after ingesting the drug) and during the 20-min post-exercise recovery. The t exh was significantly increased by CIT [PLC 258 (SD 29) s, CIT 297 (SD 45) s]. The CIT raised the rest [citrate] in blood [PLC 0.11 (SD 0.01) mmol · l−1, CIT 0.34 (SD 0.07) mmol · l−1] and in muscle [PLC 0.78 (SD 0.23) mmol · kg−1 dry mass, CIT 1.00 (SD 0.21) mmol · kg−1 dry mass]. Resting muscle pH and buffering capacity were unchanged by CIT. The same fall in muscle pH was observed during Lim-EX in the two conditions. This was associated with similar variations in both the cardio-respiratory response and muscle energy and metabolism status in spite of a better blood acid-base status after CIT. Thus, CIT would not seem to allow the alkalinization of the muscle cytosolic compartment. Though sodium citrate works in a similar way to NaHCO3 on plasma alkalinization and exercise performance, the exact nature of the mechanisms involved in the delay of exhaustion could be different and remains to be elucidated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Accepted: 26 November 1996

Rights and permissions

Reprints and permissions

About this article

Cite this article

Linossier, MT., Dormois, D., Brégère, P. et al. Effect of sodium citrate on performance and metabolism of human skeletal muscle during supramaximal cycling exercise. Eur J Appl Physiol 76, 48–54 (1997). https://doi.org/10.1007/s004210050211

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004210050211

Navigation