Abstract
Objectives
We have a weak understanding of how aerobic training may influence migraine, and the optimal parameters for exercise regimens as migraine therapy are not clear. The objectives of this study were to assess, first, effects of two different intensities of aerobic exercise on migraine headache indices; second, serum neuro-biomarker in women migraineurs.
Methods
A total of 45 non-athlete female migraine patients were selected by a neurologist and randomly divided into three groups: control (CON), moderate-intensity aerobic training (MOD T), and high-intensity aerobic training (HIGH T). Before and after the training protocol, body composition factors, migraine pain indices, VO2max, and serum Adenylate-Cyclase Activating Polypeptide (PACAP) and Substance P (SP) were measured. Exercise training protocol includes two different intensities of aerobic exercise: Moderate (13–15 Borg Scale, 60–80% HRmax) and High (15–17 Borg Scale, 65–95% HRmax).
Results
Moderate-intensity aerobic training (MOD T) reduced headache intensity, frequency, and duration in women with migraine (p < 0.001, for all). Also, high-intensity aerobic training (HIGH T) reduced headache intensity, frequency, and duration (p < 0.001, for all). However, for headache intensity and duration, MOD T was effective rather than HIGH T (p < 0.001; p ≤ 0.05, respectively). In addition, neither MOD T nor HIGH T could not alter PACAP and SP contents (p = 0.712; p = 0.249, respectively).
Conclusions
Our results demonstrated that either MOD T or HIGH T could modify migraine pain indices but neither MOD T nor HIGH T could not alter the PACAP and SP contents in women with migraine.
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Abbreviations
- BMI:
-
Body mass index
- CGRP:
-
Calcitonin gene-related peptide
- CON:
-
Control
- CRP:
-
C-reactive protein
- eCB:
-
Endocannabinoid
- HRmax:
-
Heart rate maximum
- HIGH T:
-
High-intensity aerobic training
- IL-6:
-
Interleukine-6
- NPY:
-
Neuropeptide Y
- NO:
-
Nitric oxide
- MOD T:
-
Moderate-intensity aerobic training
- PACAP:
-
Pituitary adenylate-cyclase activating polypeptide
- RCT:
-
Randomized controlled trial
- SNL:
-
Spinal nerve ligation
- SP:
-
Substance P
- VAS:
-
Visual analog scale
- VO2max:
-
Maximum volume of oxygen consumption
- WHR:
-
Waist-to-hip ratio
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Acknowledgements
The authors would like to thank the Council of Research, University of Allameh Tabataba’i (Iran), for providing financial supports.
Funding
This work was supported by the Allameh Tabataba’i University (Grant numbers: t/d/62).
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RE contributed to the data processing, statistical analysis, and drafted the manuscript; AP and ZP conceived of the study, participated in its design and coordination, run training protocols, and gathered data. PN contributed to data analysis; and BK contributed to the final edition and managed. All authors have read and approved the final version of the manuscript, and agree with the order of the presentation of the authors.
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Eslami, R., Parnow, A., Pairo, Z. et al. The effects of two different intensities of aerobic training protocols on pain and serum neuro-biomarkers in women migraineurs: a randomized controlled trail. Eur J Appl Physiol 121, 609–620 (2021). https://doi.org/10.1007/s00421-020-04551-x
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DOI: https://doi.org/10.1007/s00421-020-04551-x