Abstract
Purpose
The aim of the present study was to investigate (i) how glycolytic metabolism assessed by accumulated oxygen deficit (AODgly) and blood metabolic responses (lactate and pH) resulting from high-intensity exercise change during growth, and (ii) how lean body mass (LBM) influences AODgly and its relationship with blood markers.
Methods
Thirty-six 11- to 17-year olds performed a 60-s all-out test on a rowing ergometer. Allometric modelling was used to investigate the influence of LBM and LBM + maturity offset (MO) on AODgly and its relationship with the extreme post-exercise blood values of lactate ([La]max) and pH (pHmin) obtained during the recovery period.
Results
AODgly and [La]max increased while pHmin decreased linearly with LBM and MO (r2 = 0.46 to 0.72, p < 0.001). Moreover, AODgly was positively correlated with [La]max (r2 = 0.75, p < 0.001) and negatively correlated with pHmin (r2 = 0.77, p < 0.001). When AODgly was scaled for LBM, the coefficients of the relationships with blood markers drastically decreased by three to four times ([La]max: r2 = 0.24, p = 0.002; pHmin: r2 = 0.30, p < 0.001). Furthermore, by scaling AODgly for LBM + MO, the correlation coefficients with blood markers became even lower ([La]max: r2 = 0.12, p = 0.037; pHmin: r2 = 0.18, p = 0.009). However, MO-related additional changes accounted much less than LBM for the relationships between AODgly and blood markers.
Conclusion
The results challenge previous reports of maturation-related differences in glycolytic energy turnover and suggest that changes in lean body mass are a more powerful influence than maturity status on glycolytic metabolism during growth.
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Abbreviations
- AODgly :
-
Glycolysis-derived accumulated oxygen deficit
- AODtot :
-
Total accumulated oxygen deficit
- APHV:
-
Age at peak height velocity
- [BE]min :
-
Minimal base excess concentration
- BF:
-
Body fat
- BM:
-
Body mass
- BMI:
-
Body mass index
- CA:
-
Chronological age
- [HCO3−]min :
-
Minimal bicarbonate concentration
- HRmax :
-
Maximal heart rate
- LBM:
-
Lean body mass
- [La]max :
-
Maximal lactate concentration
- MO:
-
Maturity offset
- MPO:
-
Mean power output
- pHmin :
-
Minimal pH
- PV̇̇O2max :
-
Power at maximal oxygen uptake
- OEphos+ox :
-
Phosphagen- and blood O2 stores-derived oxygen equivalent
- \({\dot{\text{V}}\text{O}}\) 2max :
-
Maximal oxygen uptake
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Acknowledgements
The authors thank Matthieu Chapron, Adrien Druenne, Nathalie Capelle, all rowers for their participation, and the Club of Aviron Marne Joinville for their welcome, technical assistance and availability during this study.
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AD, SR, CT, and HM conceived and designed research. AD, SR, JB, CT and HM conducted experiments and collected data. AD, SR, QDL and HM analysed data. AD, SR, NA, CT and HM wrote the manuscript. AD, SR, JB, QDL, NA, CT and HM provided critical revisions important for intellectual content of the finished manuscript, approved the final version of the manuscript, and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All persons designated as authors qualify for authorship, and all those who qualify for authorship are listed.
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Diry, A., Ratel, S., Bardin, J. et al. Importance of dimensional changes on glycolytic metabolism during growth. Eur J Appl Physiol 120, 2137–2146 (2020). https://doi.org/10.1007/s00421-020-04436-z
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DOI: https://doi.org/10.1007/s00421-020-04436-z