Abstract
Purpose
We aimed at exploring whether cardiopulmonary fitness, echocardiographic measures and relative exercise intensity were associated with high-sensitivity cardiac troponin T (hs-TNT) rise and normalization following a marathon.
Methods
Nighty-eight participants (83 men, 15 women; 38.72 ± 3.63 years) were subjected to echocardiographic assessment and a cardiopulmonary exercise test (CPET) before the race. hs-TNT was measured before, immediately after and at 24, 48, 96, 144 and 192 h post-race. Speed and mean heart rate (HR) during the race were relativized to CPET values: peak speed (%VVMAX), peak HR (HR%MAX), speed and HR at the second ventilatory threshold (HR%VT2 and %VVT2).
Results
Hs-TNT increased from pre- to post-race (5.74 ± 5.29 vs. 50.4 ± 57.04 ng/L; p < 0.001), seeing values above the Upper Reference Limit (URL) in 95% of the participants. At 24 h post-race, 39% of the runners still exceeded the URL (High hs-TNT group). hs-TNT rise was correlated with marathon speed %VVT2 (r = 0.22; p = 0.042), mean HR%VT2 (r = 0.30; p = 0.007), and mean HR%MAX (r = 0.32; p = 0.004). Moreover, the High hs-TNT group performed the marathon at a higher Speed %VVT2 (88.21 ± 6.53 vs. 83.49 ± 6.54%; p = 0.002) and Speed %VVMAX (72 ± 4.25 vs. 69.40 ± 5.53%; p = 0.009). hs-TNT showed no significant associations with cardiopulmonary fitness and echocardiographic measures, except for a slight correlation with left ventricular end systolic diameter (r = 0.26; p = 0.018).
Conclusion
Post-race hs-TNT was above the URL in barely all runners. Magnitude of hs-TNT rise was correlated with exercise mean HR; whereas, its normalization kept relationship with marathon relative speed.
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Data availability
Data from the Run, Recovery, Repeat, Always Healthy Project, to whom it belong results here presented, are stored at the Sports Service of the Jaume I University of Castellon. Applications for data sharing can be made.
Abbreviations
- hs-TNT:
-
High-sensitive cardiac troponin T
- CPET:
-
Cardiopulmonary exercise test
- HR:
-
Heart rate
- URL:
-
Upper reference limit
- BMI:
-
Body mass index
- VO2max:
-
Maximum oxygen uptake
- RER:
-
Respiratory exchange ratio
- VT2 :
-
Second ventilatory threshold
- RVEDD:
-
Right ventricular end diastolic diameter
- LVEDD:
-
Left ventricular end diastolic diameter
- LVESD:
-
Left ventricular end systolic diameter
- IVS:
-
Interventricular septum at the end of diastole
- PW:
-
Posterior wall at the end of diastole
- LVEF:
-
Left ventricular ejection fraction
- ECLIA:
-
Electrochemiluminescence technology
- LoB:
-
Limit of the blank
- SD:
-
Standard deviation
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Acknowledgements
Current research could be carried out, thanks to the collaboration of Fundacion Trinidad Alfonso, Vithas-Nisa Hospitals group and Sociedad Deportiva Correcaminos. Authors are also grateful to all the staff involved in the organization of the Valencia Fundacion Trinidad Alfonso EDP 2016 Marathon and all marathoners and volunteers participating in this study.
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Fundacion Trinidad Alfonso and Vithas-Nisa Hospitals group.
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Conceived and designed the experiments: IMN JSG DS EC BH NP CH. Performed the experiments: IMN JSG DS EC BH NP CH. Analyzed the data: IMN JSG DS CH. Wrote the manuscript: IMN. All authors have read and approved the final version of the manuscript, and agree with the order of presentation of the authors.
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Research Ethics Committee of the Jaume I University of Castellon (Expedient number: DOGV 7993, 6/03/2017).
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Communicated by Massimo Pagani.
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Martínez-Navarro, I., Sánchez-Gómez, J., Sanmiguel, D. et al. Immediate and 24-h post-marathon cardiac troponin T is associated with relative exercise intensity. Eur J Appl Physiol 120, 1723–1731 (2020). https://doi.org/10.1007/s00421-020-04403-8
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DOI: https://doi.org/10.1007/s00421-020-04403-8