Aerobic or resistance exercise performed the previous day does not attenuate postprandial hyperglycemia-induced endothelial dysfunction in overweight/obese adults
Postprandial hyperglycemia (PPH) impairs vascular endothelial function (VEF). A single bout of aerobic exercise (AE) attenuates PPH-induced decreases in brachial artery flow-mediated dilation (FMD), a non-invasive measure of VEF, in healthy adults for up to 17 h post-exercise. Studies examining the effects of resistance exercise (RE) on postprandial FMD responses are lacking.
We hypothesized that a single bout of exercise performed the prior evening would attenuate PPH-induced decreases in FMD, independent of exercise modality.
In a randomized, cross-over design, overweight/obese adults [n = 11 (8 women); 22 ± 4 years; 32.3 ± 5.8 kg m−2] completed 3 separate trials: control (seated rest), AE (30 min at ~ 60% VO2max), or whole-body RE (30 min, 6 exercises, 3 × 10-repetition maximum). Each trial occurred 14–17 h prior to an oral glucose tolerance test (OGTT). Brachial artery FMD and plasma glucose and insulin were measured prior to and at 30-min intervals for 2 h following the OGTT. Repeated-measures ANOVA and Bonferroni post hoc tests were used to evaluate differences within and between trials.
Trials occurred 15.3 ± 1.0 h prior to the OGTT. Relative to baseline, FMD transiently decreased (P < 0.05) at 30–60 min post-ingestion, plasma glucose increased (P < 0.01) at 30–90 min post-ingestion, and plasma insulin increased (P < 0.01) at 30–120 min post-ingestion. No between trial differences were observed for FMD, glucose, or insulin.
Aerobic or resistance exercise performed the evening prior to an OGTT does not attenuate postprandial decreases in brachial artery FMD in overweight/obese adults.
KeywordsFlow-mediation dilation Insulin Glucose Acute exercise
Analysis of variance
Area under the curve
Body mass index
Diastolic blood pressure
Enzyme-linked immunosorbent assay
High-density lipoprotein cholesterol
Homeostatic model assessment of insulin resistance
Low-density lipoprotein cholesterol
Oral glucose tolerance test
Respiratory exchange ratio
Rating of perceived exertion
Systolic blood pressure
Vascular endothelial function
Maximal oxygen consumption
This study was supported by a College of Education, Health, and Society Seed Grant and Miami University Committee for Faculty Research Award. The authors acknowledge the contributions of our participants.
KB, CB, and CV conceived and designed research. KB, CB, CV, and KA conducted experiments and analyzed data. KB and KT wrote the manuscript. All the authors read and approved the manuscript.
Conflict of interest
The authors declare that they have no conflict of interest.
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