Abstract
Introduction
Menopause is accompanied by decreased aerobic fitness and increased risk of cardiovascular disease. Sprint interval training (SIT) is a time-efficient intervention for improving cardiovascular function and aerobic fitness of young adults.
Aim
To determine the effect of an 8-week SIT program on the cardiovascular function and aerobic fitness of overweight postmenopausal women.
Method
Thirty overweight postmenopausal women were randomized into exercise (n = 15) or control (n = 15) groups. The intervention group completed three SIT sessions a week for 8 weeks. Each session consisted of 20 min of 8-s sprints and 12 s of light pedalling. Participants also completed 8 min of light aerobic cycle exercise, before and after the SIT intervention. Cardiovascular function including heart rate, stroke volume (SV), and diastolic filling time (DFT) was assessed before and after the intervention and during 8 min of light aerobic exercise. Estimated maximal oxygen uptake (\(\dot {V}{{\text{O}}_{2{\text{max}}}}\)) was also assessed.
Results
Resting SV was increased (p = 0.001) from pre- (77.5 ± 17.0 mL) to post-SIT (81.3 ± 17.0 mL), whereas SV during 8 min of light aerobic exercise was increased (p = 0.000), from pre- (97.8 ± 1.6 mL) to post-test (103.5 ± 17.8 mL). Resting DFT was increased, (p = 0.010), at pre- (333.4 ± 94.4 mL) to post-SIT (357.4 ± 88.2 mL), whereas DFT during 8 min of aerobic exercise was increased, (p = 0.000), from pre- (480.1 ± 99.5 mL) to posttest (527.2 ± 123.0 mL). Predicted \(\dot {V}{{\text{O}}_{2{\text{max}}}}\) was increased, (p = 0.016), from pre- (19.5 ± 5.87 mL kg−1 min−1) to post-SIT (21.4 ± 7.02 mL kg−1 min−1).
Conclusion
SIT improved cardiovascular function and aerobic fitness of overweight postmenopausal women after 8 weeks of exercise.
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Abbreviations
- ANCOVA:
-
Analysis of co-variance
- BMI:
-
Body mass index
- BPM:
-
Beats per minute
- BSA:
-
Body surface area
- BP:
-
Blood pressure
- CI:
-
Cardiac index
- CO:
-
Cardiac output
- COP:
-
Cardiac output program
- CRF:
-
Cardiorespiratory fitness
- DFT:
-
Diastolic filling time
- ECG:
-
Electrocardiography
- HR:
-
Heart rate
- SIT:
-
Sprint interval training
- LV:
-
Left ventricular
- LVET:
-
Left ventricular ejection time
- PEP:
-
Pre-ejection period
- RPE:
-
Rating of perceived exertion
- RPM:
-
Revolutions per minute
- SI:
-
Stroke index
- SSE:
-
Steady-state exercise
- SV:
-
Stroke volume
- TPR:
-
Total peripheral resistance
- VER:
-
Ventricular emptying rate
- \(\dot {V}{{\text{O}}_2}\) :
-
Oxygen uptake
- \(\dot {V}{\text{C}}{{\text{O}}_2}\) :
-
Carbon dioxide production
- \(\dot {V}{{\text{O}}_{2{\text{max}}}}\) :
-
Maximal oxygen uptake
- VFT:
-
Ventricular filling time
- W:
-
Watts
References
Arena M, Myers J, Forman DE, Lavie CJ, Guazzi M (2013) Should high-intensity aerobic interval training become the clinical standard in heart failure? Heart Fail Rev 18(1):95–105
Baggish AL, Yared K, Wang F et al (2008) The impact of endurance exercise training on left ventricular systolic mechanics. Am J Physiol Heart Circ Physiol 295:1109–1116
Blair SN (2009) Physical inactivity: the biggest public health problem of the 21st century. Br J Sports Med 43:1–2
Borg G (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14(5):377–381
Boutcher SH (2011) High-intensity intermittent exercise and fat loss. J Obes 2011:868305. https://doi.org/10.1155/2011/868305
Boutcher SH, McLaren PF, Cotton Y, Boutcher Y (2003) Stroke volume response to incremental submaximal exercise in aerobically trained, active, and sedentary men. Can J Appl Physiol 28:12–26
Convertino VA (2007) Blood volume response to physical activity and inactivity. Am J Med Sci 334(1):72–79
Dill DB, Costill DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37(2):247–248
Dimsdale JE, Ziegler MG (1991) What do plasma and urinary measures of catecholamines tell us about human response to stressors? Circulation 83(4):II36–I42
Dubois D, Dubois EF (1916) A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 17:863–871
Dunn SL, Siu W, Freund J, Boutcher SH (2014) The effect of a lifestyle intervention on metabolic health in young women. Diabetes Metab Syndr Obes 7:437–444
Ehlert RE, Schmidt HD (1982) An experimental evaluation of impedance cardiographic and electromagnetic measurements of stroke volume. J Med Engl Technol 6:193–200
Fairbarn MS, Blackie SP, McElvaney NG, Wiggs BR, Pare PD, Pardy RL (1994) Prediction of heart rate and oxygen uptake during incremental and maximal exercise in healthy adults. Chest 105(5):1365–1369
Gahreman DE, Heydari M, Boutcher YN, Freund J, Boutcher SH (2016) The effects of green tea extract consumption and high-intensity intermittent on fat oxidation exercise on body composition of overweight men. Nutrients 8:510. https://doi.org/10.3390/nu8080510
Godshall RW, Bauer TA, Fahrner SL (1996) Cycling cadence alerts exercise hemodynamics. Int J Sports Med 17:17–21
Goldstein DS, Cannon RO, Zimlichman R, Keiser HR (1986) Clinical evaluation of impedance cardiography. Clin Physiol 6:235–251
Hammond AK, White FC, Brunton LL, Longhurst JC (1987) Association of decreased myocardial β-receptors and chronotropic response to isoproterenol and exercise in pigs following chronic dynamic exercise. Circ Res 60:720–726
Haykowsky M, McGavock J, Muhll IV, Koller M, Mandic RW, Taylor D (2005) Effect of exercise training on peak aerobic power, left ventricular morphology and muscle strength in healthy older women. J Gerontol A Biol Sci Med Sci 60:307–311
Heydari M, Freund J, Boutcher SH (2012) The effect of high-intensity intermittent exercise on body composition of overweight young males. J Obes 2012:480467. https://doi.org/10.1155/2012/480467
Heydari M, Boutcher YN, Boutcher SH (2013) The effects of high-intensity intermittent exercise training on cardiovascular response to mental and physical challenge. Int J Psychophysiol 87:141–146
Kubicek WG, Karnegis JN, Patterson RP (1966) Development and evaluation of an impedance cardiac output system. Aerosp Med 43:1208–1221
Lavie CJ, Arena R, Swift DL, Johannsen NM, Sui X, Lee DC (2015) Exercise and the cardiovascular system: clinical science and cardiovascular outcomes. Circ Res 119:207–219
Levy WC, Cerqueira MD, Abrass IB, Schwartz RS, Stratton JR (1993) Endurance exercise training augments diastolic filling at rest and during exercise in healthy young and older men. Circulation 88:116–126
Maillard F, Rousset S, Pereira B et al (2016) High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes Metab. https://doi.org/10.1016/j.diabet.2016.07.031
Milsom I, Forssman L, Biber B, Dottori O, Silvertsson R (1983) Measurement of cardiac stroke volume during cesarean section: a comparison between impedance cardiography and the dye dilution technique. Acta Anaesthesiol Scand 27:421–426
Moore RL (2006) The cardiovascular system: cardiac function. In: Tipton CM (ed) ACSM advanced exercise physiology. Lippincott Williams and Wilkins, Philadelphia, pp 326–342
Perez-Lopez FR, Chedraui P, Gilbert JJ, Perez-Roncero G (2009) Cardiovascular risk in menopausal women and prevalent related co-morbid conditions: facing the post-Women’s Health Initiative era. Fertil Steril 92:1171–1186
Robergs RA, Landwehr R (2002) The surprising history of the “HRmax = 220-age” equation. J Exerc Physiol 5:1–10
Sallis JF, Buono MJ, Roby JJ, Micale FG, Nelson JA (1993) Seven-day recall and other physical activity self-reports in children and adolescents. Med Sci Sports Exerc 25:99–108
Sherwood A, Allen MT, Fahrenberg J (1990) Methodological guidelines for impedance cardiography. Psychophysiology 27:1–23
Spina RJ, Ogawa T, Kohrt WM, Martin WH III, Holloszy JO, Ehsani AA (1993) Differences in cardiovascular adaptations to endurance exercise training between older men and women. J Appl Physiol 75:849–855
Stachenfeld NS, Mack GW, DiPietro L, Morocco TS, Jozsi AC, Nadel ER (1998) Regulation of blood volume during training in post-menopausal women. Med Sci Sports Exerc 30(1):92–98
Strom CC, Aplin M, Ploug T et al (2005) Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy. FEBS J 272:2684–2695
Trapp EG, Chisholm DJ, Freund J, Boutcher SH (2008) The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes 4(32):684–691
Trilk JL, Singhal A, Bigelman A, Cureton KJ (2011) Effect of sprint interval training on circulatory function during exercise in sedentary, overweight/obese women. Eur J Appl Physiol 111:1581–1597
Warburton DE, Haykowsky MJ, Quinney HA, Blackmore D, Teo KK, Taylor DA, McGavock J, Humen DP (2004) Blood volume expansion and cardiorespiratory function: effects of training modality. Med Sci Sports Exerc 36:991–1000
Weiner RB, Baggish AL (2012) Exercise-induced cardiac remodelling. Prog Cardiovasc Dis 54:380–386
Wenner MM, Stachenfeld NS (2012) Blood pressure and water regulation: understanding sex hormone effects within and between men and women. J Physiol 590:5949–5961
Williams BO, Caird FI (1985) Accuracy of the impedance cardiogram in the measurement of cardiac output in the elderly. Age Ageing 14:277–281
Wisloff U, Ellingsen O, Kemi OJ (2009) High-intensity interval training to maximize cardiac benefits of exercise training? Exerc Sport Sci Rev 37:139–146
Zhao Z, Wang H, Jessup JA, Lindsey SH, Chappell MC, Groban L (2014) Role of estrogen in diastolic dysfunction. Am J Physiol Heart Circ Physiol 306:628–640
Acknowledgements
We would like to thank Tze Yuen Ho, Vrischika Chabella, Alexandra Gleeson, Georgia Redmayne, Aengus Tran, Susan Li, and Helen Yoo for help with participant exercise training.
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DZ and TJ’s contributions to the manuscript were equal. They shared first authorship. They organized data collection, data and statistical analyses, and contributed to the manuscript development. SB was responsible for the study design and manuscript development. YB organized participant recruitment, the testing timetable, statistical analyses, study design, and manuscript development.
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None of the authors had a personal or financial conflict of interest. The study received no sources of funding. The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation.
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Communicated by Keith Phillip George.
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Zhang, D., Janjgava, T., Boutcher, S.H. et al. Cardiovascular response of postmenopausal women to 8 weeks of sprint interval training. Eur J Appl Physiol 119, 981–989 (2019). https://doi.org/10.1007/s00421-019-04087-9
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DOI: https://doi.org/10.1007/s00421-019-04087-9