Abstract
Purpose
Blood flow restricted resistance exercise (BFR-RE) is an emerging hypertrophy training modality. A complete profile of its mechanisms of action has yet to be elucidated. Cytokines are universal intercellular messengers. Recent research has implicated certain cytokines (termed “myokines”) in skeletal muscle hypertrophy pathways; however, little research has been conducted on the systemic myokine response to BFR-RE as potential hypertrophic biomarkers. Therefore, this project was conducted to determine any differences in the systemic myokine response between BFR-RE and control conditions.
Methods
The appearance of systemic myokines interleukin-6 (IL-6), interleukin-15 (IL-15), and decorin were measured following acute bouts of low-load resistance exercise, BFR-RE, and high-load resistance exercise in physically active young males to determine if BFR-RE modifies the exercise-induced systemic myokine response.
Results
No measurable levels of IL-6 were observed during the project. No significant effects were observed for IL-15. A significant time (11.91% increase pre to post exercise; p < 0.05) but no condition or condition by time effect was observed for decorin.
Conclusion
These findings suggest that BFR-RE does not modify the systemic myokine appearance of IL-6, IL-15, or decorin when compared to control conditions.
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Abbreviations
- ABPI:
-
Ankle–brachial pressure index
- ANOVA:
-
Analysis of variance
- APMHR:
-
Age-predicted maximum heart rate
- BFR-RE:
-
Blood flow restricted resistance exercise
- EDTA:
-
Ethylenediaminetetraacetic acid
- ELISA:
-
Enzyme-linked immunosorbent assay
- HL-RE:
-
High-load resistance exercise
- HRR:
-
Heart rate reserve
- IL-6:
-
Interleukin-6
- IL-15:
-
Interleukin-15
- LL-RE:
-
Low-load resistance exercise
- NSAID:
-
Non-steroidal anti-inflammatory drugs
- PAR-Q+:
-
Physical activity readiness questionnaire plus
- RHR:
-
Resting heart rate
- STAT3:
-
Signal transducer and activator of transcription 3
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The authors would like to thank the participants for volunteering their time and efforts for this study.
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EB conceived and designed the research as well as conducted the experiments. EB and SC analyzed data. EB wrote the manuscript. TD, JP, and SC refined the research design, data collection, data analysis, interpretation, and manuscript writing. All authors read and approved the manuscript.
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Communicated by Fabio Fischetti.
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Bugera, E.M., Duhamel, T.A., Peeler, J.D. et al. The systemic myokine response of decorin, interleukin-6 (IL-6) and interleukin-15 (IL-15) to an acute bout of blood flow restricted exercise. Eur J Appl Physiol 118, 2679–2686 (2018). https://doi.org/10.1007/s00421-018-3995-8
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DOI: https://doi.org/10.1007/s00421-018-3995-8