European Journal of Applied Physiology

, Volume 116, Issue 3, pp 471–480 | Cite as

Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations

  • Jacob Uth
  • Therese Hornstrup
  • Jesper F. Christensen
  • Karl B. Christensen
  • Niklas R. Jørgensen
  • Eva W. Helge
  • Jakob F. Schmidt
  • Klaus Brasso
  • Jørn W. Helge
  • Markus D. Jakobsen
  • Lars L. Andersen
  • Mikael Rørth
  • Julie Midtgaard
  • Peter Krustrup
Original Article

Abstract

Purpose

To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT).

Methods

This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years). The activity profile was measured using a 5-Hz GPS. The outcomes were total body and leg bone mineral content (BMC) and density, BTMs and postural balance.

Results

In the last part of the 12 weeks, FTG performed 194 ± 41 accelerations and 296 ± 65 decelerations at >0.6 m/s/s and covered a distance of 905 ± 297 m at speeds >6 km/h and 2646 ± 705 m per training session. Analysis of baseline-to-12-week change scores showed between-group differences in favour of FTG in total body BMC [26.4 g, 95 % confidence interval (CI): 5.8–46.9 g, p = 0.013], leg BMC (13.8 g, 95 % CI: 7.0‒20.5 g, p < 0.001) and markers of bone formation: P1NP (36.6 µg/L, 95 % CI: 10.4‒62.8 µg/L, p = 0.008) and osteocalcin (8.6 µg/L, 95 % CI: 3.3‒13.8 µg/L, p < 0.01). The number of decelerations correlated to the increase in leg BMC (r = 0.65, p = 0.012). No between-group differences were observed for the remaining outcomes.

Conclusion

Football training involves numerous runs, accelerations and decelerations, which may be linked to marked increases in bone formation markers and preserved bone mass in middle-aged and elderly men with PCa undergoing ADT.

Trial registration

ClinicalTrials.gov: NCT01711892.

Keywords

GPS Exercise intensity Bone turnover markers (BTM) Bone mineral content (BMC) Association football Prostate cancer 

Abbreviations

ADT

Androgen deprivation therapy

BMI

Body mass index

BMC

Bone mineral content

BMD

Bone mineral density

BTMs

Bone turnover markers

CI

Confidence interval

CON

Standard care control group

CTX

C-terminal telopeptide of type I collagen

DXA

Dual-energy X-ray absorptiometry

FC

Football club

FTG

Football training group

GPS

Global positioning system

PCa

Prostate cancer

P1NP

Procollagen type 1 amino-terminal propeptide

SD

Standard deviation

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Jacob Uth
    • 1
  • Therese Hornstrup
    • 2
  • Jesper F. Christensen
    • 12
  • Karl B. Christensen
    • 6
  • Niklas R. Jørgensen
    • 9
    • 11
  • Eva W. Helge
    • 2
  • Jakob F. Schmidt
    • 2
  • Klaus Brasso
    • 4
  • Jørn W. Helge
    • 10
  • Markus D. Jakobsen
    • 5
  • Lars L. Andersen
    • 5
    • 13
  • Mikael Rørth
    • 7
  • Julie Midtgaard
    • 1
    • 8
  • Peter Krustrup
    • 2
    • 3
  1. 1.University Hospitals Centre for Health Research (UCSF), Rigshospitalet, University of CopenhagenCopenhagenDenmark
  2. 2.Department of Nutrition, Exercise and Sports, Copenhagen Centre for Team Sport and HealthUniversity of CopenhagenCopenhagenDenmark
  3. 3.Sport and Health Sciences, College of Life and Environmental SciencesUniversity of Exeter, St Luke’s CampusExeterUK
  4. 4.Copenhagen Prostate Cancer Center, Department of Urology, RigshospitaletUniversity of CopenhagenCopenhagenDenmark
  5. 5.National Research Centre for the Working EnvironmentCopenhagenDenmark
  6. 6.Department of BiostatisticsUniversity of CopenhagenCopenhagenDenmark
  7. 7.Department of Oncology, RigshospitaletUniversity of CopenhagenCopenhagenDenmark
  8. 8.Department of Public HealthUniversity of CopenhagenCopenhagen KDenmark
  9. 9.Department of Clinical Biochemistry, RigshospitaletResearch Center for Ageing and OsteoporosisGlostrupDenmark
  10. 10.Center for Healthy Aging, Department of Biomedical SciencesUniversity of CopenhagenCopenhagenDenmark
  11. 11.Institute of Clinical ResearchUniversity of Southern DenmarkOdenseDenmark
  12. 12.Centre for Physical Activity Research, RigshospitaletUniversity of CopenhagenCopenhagenDenmark
  13. 13.Physical Activity and Human Performance Group, SMI, Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

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