European Journal of Applied Physiology

, Volume 114, Issue 8, pp 1749–1755 | Cite as

Creatine supplementation prevents acute strength loss induced by concurrent exercise

  • Vítor de Salles Painelli
  • Victor Tavares Alves
  • Carlos Ugrinowitsch
  • Fabiana Braga Benatti
  • Guilherme Giannini Artioli
  • Antonio Herbert LanchaJr
  • Bruno Gualano
  • Hamilton RoschelEmail author
Original Article



To investigate the effect of creatine (CR) supplementation on the acute interference induced by aerobic exercise on subsequent maximum dynamic strength (1RM) and strength endurance (SE, total number of repetitions) performance.


Thirty-two recreationally strength-trained men were submitted to a graded exercise test to determine maximal oxygen consumption (VO2max: 41.56 ± 5.24 ml kg−1 min−1), anaerobic threshold velocity (ATv: 8.3 ± 1.18 km h−1), and baseline performance (control) on the 1RM and SE (4 × 80 % 1RM to failure) tests. After the control tests, participants were randomly assigned to either a CR (20 g day−1 for 7 days followed by 5 g day−1 throughout the study) or a placebo (PL-dextrose) group, and then completed 4 experimental sessions, consisting of a 5-km run on a treadmill either continuously (90 % ATv) or intermittently (1:1 min at vVO2max) followed by either a leg- or bench-press SE/1RM test.


CR was able to maintain the leg-press SE performance after the intermittent aerobic exercise when compared with C (p > 0.05). On the other hand, the PL group showed a significant decrease in leg-press SE (p ≤ 0.05). CR supplementation significantly increased bench-press SE after both aerobic exercise modes, while the bench-press SE was not affected by either mode of aerobic exercise in the PL group. Although small increases in 1RM were observed after either continuous (bench press and leg press) or intermittent (bench press) aerobic exercise in the CR group, they were within the range of variability of the measurement. The PL group only maintained their 1RM.


In conclusion, the acute interference effect on strength performance observed in concurrent exercise may be counteracted by CR supplementation.


Creatine supplementation Interference Resistance training Fatigue 



Maximum dynamic strength


Anaerobic threshold velocity




Continuous aerobic exercise and strength endurance assessment condition


Continuous aerobic exercise and maximum strength assessment condition




High-performance liquid chromatography


Maximum heart rate


Intermittent aerobic exercise and strength endurance assessment condition


Continuous aerobic exercise and maximum strength assessment condition




Strength endurance


Ventilatory equivalent for carbon dioxide


Carbon dioxide output


Oxygen consumption


Maximal oxygen consumption


Maximal oxygen consumption velocity



The authors are grateful to all subjects who participated in the study. Vitor de Salles Painelli is supported by FAPESP (Grant 2013/04806-0). CU was supported by CNPq (Grant 304205/2011-7). The authors are grateful to Probiótica for the donation of Creapure®.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Vítor de Salles Painelli
    • 1
  • Victor Tavares Alves
    • 1
  • Carlos Ugrinowitsch
    • 1
  • Fabiana Braga Benatti
    • 1
  • Guilherme Giannini Artioli
    • 1
  • Antonio Herbert LanchaJr
    • 1
  • Bruno Gualano
    • 1
  • Hamilton Roschel
    • 1
    Email author
  1. 1.School of Physical Education and SportUniversity of Sao PauloSão PauloBrazil

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