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Blood pressure regulation XI: overview and future research directions


While the importance of regulating arterial blood pressure within a ‘normal’ range is widely appreciated, the definition of ‘normal’ and the means by which humans and other species regulate blood pressure under various conditions remain hotly debated. The effects of diverse physiological, pathological and environmental challenges on blood pressure and the mechanisms that attempt to maintain it at an optimal level are reviewed and critically analyzed in a series of articles published in this themed issue of the European Journal of Applied Physiology. We summarize here the major points made in these reviews, with emphasis on unifying concepts of regulatory mechanisms and future directions for research.

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Mean arterial pressure


Nucleus tractus solitarii


Reactive oxygen species


Nitric oxide

Ang II:

Angiotensin II


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Research performed in the Chapleau laboratory related to the topics discussed was supported by funding provided by the NIH (P01 HL14388) and the U.S. Department of Veterans Affairs (1 I01 BX001414) and in the Raven laboratory was supported by funding provided by the NIH (RO-1 grant #s HL045547 and R-21 Grant # HL106431).

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Correspondence to Peter B. Raven.

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Communicated by Nigel A.S. Taylor.

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Raven, P.B., Chapleau, M.W. Blood pressure regulation XI: overview and future research directions. Eur J Appl Physiol 114, 579–586 (2014).

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  • Arterial baroreflex resetting
  • Cardiac output
  • Hemodynamic responses
  • Hypertension
  • Reactive oxygen species
  • Set-point theory
  • Operating point
  • Total peripheral resistance