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Effects of feeding schedule changes on the circadian phase of the cardiac autonomic nervous system and serum lipid levels

Abstract

Purpose

The purpose of this study was to investigate whether scheduling meals earlier in the day affects the circadian phase of the cardiac autonomic nervous system as assessed by heart rate variability (HRV) and serum lipid levels.

Methods

Healthy men aged 21.4 ± 0.5 years (n = 14) with a habit of regularly skipping breakfast participated in this parallel trial involving altered feeding schedules. Participants in the early mealtime group (EM group, n = 8) were asked to eat three meals at 8:00, 13:00, and 18:00, and the control group (n = 6) ate at 13:00, 18:00, and 23:00 for 2 weeks. On the measurement day before and after intervention, fasting blood samples and 24-h electrocardiograph recordings were collected. Spectral analysis was used for approximate 10-min HRV segments. Low frequency (LF) power, high frequency (HF) power, and the ratio of HF to total power (%HF) were calculated to assess sympathovagal balance. Acrophases of the circadian rhythm of HRV variables were obtained by nonlinear least squares regression.

Results

Triglyceride and total and LDL cholesterol levels were significantly decreased in the EM group when compared with the control group (p = 0.035, 0.008, and 0.004, respectively). Acrophases for HRV variables were advanced in the EM group and their difference between before and after the intervention in LF power (−3.2 ± 1.2 h) and %HF (−1.2 ± 0.5 h) reached significant level, respectively (p < 0.05).

Conclusions

Timing of meals was a key factor in regulating circadian phases of the cardiac autonomic nervous system and lipid metabolism.

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Abbreviations

Bmal1:

Brain and muscle arnt-like protein-1

BMI:

Body mass index

ECG:

Electrocardiography

HF power:

High frequency power

HOMA-β:

Homeostasis model assessment for beta cell function

HOMA-IR:

Homeostasis model assessment for insulin resistance

HR:

Heart rate

HRV:

Heart rate variability

LF power:

Low frequency power

NEFA:

Non-esterified fatty acid

RRI:

R–R intervals

TG:

Triglyceride

%HF:

The ratio of HF to total power

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Acknowledgments

We acknowledge the support of Manami Suzuki, Momoko Nishimura, and Kana Maeda in the Department of Nutritional Science, Faculty of Applied Biosciences, Tokyo University of Agriculture and the cooperation of study participants. This study was supported by a Grant-in-Aid for Research Fellowships of Japan Society for the Promotion of Science for Young Scientists.

Conflict of interest

The authors declare no conflicts of interest.

Ethical Standards

The experiments described herein comply with the current laws of Japan.

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Correspondence to Yukari Kawano.

Additional information

Communicated by Massimo Pagani.

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Yoshizaki, T., Tada, Y., Hida, A. et al. Effects of feeding schedule changes on the circadian phase of the cardiac autonomic nervous system and serum lipid levels. Eur J Appl Physiol 113, 2603–2611 (2013). https://doi.org/10.1007/s00421-013-2702-z

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Keywords

  • Feeding schedule
  • Autonomic nervous system
  • Heart rate variability
  • Lipid level
  • Chrononutrition