Effect of cryotherapy on muscle recovery and inflammation following a bout of damaging exercise
- 5.6k Downloads
The purpose of this study was to determine the effect of cryotherapy on the inflammatory response to muscle-damaging exercise using a randomized trial. Twenty recreationally active males completed a 40-min run at a −10 % grade to induce muscle damage. Ten of the subjects were immersed in a 5 °C ice bath for 20 min and the other ten served as controls. Knee extensor peak torque, soreness rating, and thigh circumference were obtained pre- and post-run, and 1, 6, 24, 48, and 72 h post-run. Blood samples were obtained pre- and post-run, and 1, 6 and 24 h post-run for assay of plasma chemokine ligand 2 (CCL2). Peak torque decreased from 270 ± 57 Nm at baseline to 253 ± 65 Nm post-run and increased to 295 ± 68 Nm by 72 h post-run with no differences between groups (p = 0.491). Soreness rating increased from 3.6 ± 6.0 mm out of 100 mm at baseline to 47.4 ± 28.2 mm post-run and remained elevated at all time points with no differences between groups (p = 0.696). CCL2 concentrations increased from 116 ± 31 pg mL−1 at baseline to 293 ± 109 pg mL−1 at 6 h post-run (control) and from 100 ± 27 pg mL−1 at baseline to 208 ± 71 pg mL−1 at 6 h post-run (cryotherapy). The difference between groups was not significant (p = 0.116), but there was a trend for lower CCL2 in the cryotherapy group at 6 h (p = 0.102), though this measure was highly variable. In conclusion, 20 min of cryotherapy was ineffective in attenuating the strength decrement and soreness seen after muscle-damaging exercise, but may have mitigated the rise in plasma CCL2 concentration. These results do not support the use of cryotherapy during recovery.
KeywordsEccentric exercise Downhill run Inflammation Chemokine ligand-2
Plasma chemokine ligand 2
Delayed-onset muscle soreness
Maximal voluntary contraction
Visual analog scale for soreness
The authors would like to thank the subjects who participated in this study. This study was conducted with no external funding.
Conflict of interest
The authors report no conflict of interest.
- Giraldo E, Garcia JJ, Hinchado MD, Ortega E (2009) Exercise intensity-dependent changes in the inflammatory response in sedentary women: role of neuroendocrine parameters in the neutrophil phagocytic process and the pro-/anti-inflammatory cytokine balance. NeuroImmunoModulation 16(4):237–244PubMedCrossRefGoogle Scholar
- Lu H, Huang D, Ransohoff RM, Zhou L (2011) Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair. Faseb J 25(10):3344–55 (Epub 2011 Jun 22)Google Scholar
- Moreno LA, Joyanes M, Mesana MI, Gonzalez-Gross M, Gil CM, Sarria A, Gutierrez A, Garaulet M, Perez-Prieto R, Bueno M, Marcos A, AVENA Study Group (2003) Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents. Nutrition 19(6):481–486PubMedCrossRefGoogle Scholar