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European Journal of Applied Physiology

, Volume 113, Issue 10, pp 2531–2540 | Cite as

Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females

  • G. RacilEmail author
  • O. Ben Ounis
  • O. Hammouda
  • A. Kallel
  • H. Zouhal
  • K. Chamari
  • M. Amri
Original Article

Abstract

Purpose

We investigate the effects of 12-week interval training of moderate- or high-intensity exercise on blood lipids and plasma levels of adiponectin.

Methods

Thirty-four obese adolescent females [age = 15.9 ± 0.3 years; BMI and BMI-Z-score = 30.8 ± 1.6 kg/m2 and 3 ± 0.3, respectively], were randomized to high-intensity interval training (HIIT, n = 11), moderate-intensity interval training (MIIT, n = 11), or a control group (CG, n = 12). Maximal oxygen uptake (\(\mathop V\limits^{.} {\text{O}}_{{2{\text{peak}}}}\)), maximal aerobic speed (MAS), plasma lipids and adiponectin levels were measured in all subjects before and after training.

Results

Following the training program, in both training groups, body mass, BMI-Z-score, and percentage body fat (% BF) decreased, while \(\mathop V\limits^{.} {\text{O}}_{{2{\text{peak}}}}\) and MAS increased. Low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and adiponectin levels were positively altered (−12.6 and −7.4 %; 6.3 and 8.0 %; 35.8 and 16.2 %; high to moderate training program, respectively). Waist circumference, triglyceride and total cholesterol decreased only in HIIT group (−3.5; −5.3 and −7.0 %, respectively, in all P < 0.05). Significant decrease in the usual index of insulin resistance (HOMA-IR) occurred in HIIT and MIIT groups (−29.2 ± 5.3 and −18.4 ± 8.6 %, respectively; P < 0.01).

Conclusion

The results show that HIIT positively changes blood lipids and adiponectin variables in obese adolescent girls, resulting in improved insulin sensitivity, as attested by a lower HOMA-IR, and achieving better results compared to moderate-intensity exercise.

Keywords

Training intensity Intermittent exercise Adipose tissue Insulin resistance Adolescent 

Notes

Acknowledgments

The present study was supported by the Ministry of Higher Education, Scientific Research and Technology of Tunisia. The authors are grateful to all of the adolescents for their cooperation; we also thank Dr. Kaabachi N., Dr. Jemaa R., Dr. Garbi A. and the dietician Miss Mrad for their medical assistance.

Conflict of interest

The authors declare that they have no conflict of interest related to the publication of this article.

References

  1. Atkinson RL, Walberg-Rankin J (1994) Physical activity, fitness and severe obesity. Physical Activity, Fitness and Health: International Proceeding and Consensus StatementGoogle Scholar
  2. Balagopal P, George D, Yarandi H, Funanage V, Bayne E (2005) Reversal of obesity-related hypo-adiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents. J Clin Endocrinol Metab 90:6192–6197PubMedCrossRefGoogle Scholar
  3. Bangsbo J, Graham T, Johansen L, Saltin B (1994) Muscle lactate metabolism in recovery from intense exhaustive exercise—impact of light exercise. J Appl Physiol 77:1890–1895PubMedGoogle Scholar
  4. Bartlett JD, Close GL, MacLaren DPM, Gregson W, Drust B, Morton JP (2011) High intensity-interval running is perceived to be more enjoyable than moderate intensity continuous exercise: implications for exercise adherence. J Sports Sci 29:547–553. doi: 10.1080/02640414.2010.545427 PubMedCrossRefGoogle Scholar
  5. Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z (2008) Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br J SportsMed (in press)Google Scholar
  6. Boutcher SH (2011) High-intensity intermittent exercise and fat loss. J Obes. Article ID 868305Google Scholar
  7. Brooks GA, Mercier J (1994) Balance of carbohydrate and lipid utilization during exercise: the crossover concept. J Appl Physiol 76:2253–2261PubMedGoogle Scholar
  8. Buchan DS, Ollis S, Young JD, Thomas NE, Cooper S, Tong TK et al (2011) The effects of time and intensity of exercise on novel and established markers of CVD in adolescent youth. Am J Hum Biol 23:517–526. doi: 10.1002/ajhb.21166 PubMedCrossRefGoogle Scholar
  9. Chtara M, Chamari K, Chaouachi M, Chaouachi A, Koubaa D, Feki Y, Millet GP, Amri M (2005) Effects of intra-session concurrent endurance and strength training sequence on aerobic performance and capacity. Br J Sports Med 39:555–560PubMedCrossRefGoogle Scholar
  10. Coker RH, Williams RH, Yeo SE, Kortebein PM, Bodenner DL, Kern PA, Evans WJ (2009) The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity. J Clin Endocrinol Metab 94:4258–4266PubMedCrossRefGoogle Scholar
  11. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320:1240–1243PubMedCrossRefGoogle Scholar
  12. Coquart JB, Lemaire C, Dubart AE, Luttembacher DP, Douillard C, Garcin M (2008a) Intermittent versus continuous exercise: effects of perceptually lower exercise in obese women. Med Sci Sports Exerc 40(8):154653. doi: 10.1249/MSS.0b013e31816fc30c Google Scholar
  13. Coquart JB, Lemaire C, Douillard C, Garcin M (2008b) Effets d’un programme de marche intermittente sur la masse et la composition corporelles de femmes obèses. Ann Endocrinol 69:227–230. doi: 10.1016/j.ando.2008.01.006 CrossRefGoogle Scholar
  14. Cornish AK, Broadbent S, Cheema BS (2011) Interval training for patients with coronary artery disease: a systematic review. Eur J Appl Physiol 111:579–589PubMedCrossRefGoogle Scholar
  15. Crouse SF, O’Brien BC, Grandjean PW, Lowe RC, Rohack JJ, Green JS (1997) Effects of training and a single session of exercise on lipids and apolipoproteins in hyper-cholesterolaemic men. J App Physiol 83:2019–2028Google Scholar
  16. Dai S, Fulton JE, Harrist RB, Grunbaum JA, Steffen LM, Labarthe DR (2009) Blood lipids in children: age-related patterns and association with body-fat indices: project heartbeat. Am J Prev Med 37:56–64CrossRefGoogle Scholar
  17. DeBusk RF, Stenestrand U, Sheehan M, Haskell WL (1990) Training effects of long versus short bouts of exercise in healthy subjects. Am J Cardi 65(15):101–103Google Scholar
  18. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502PubMedGoogle Scholar
  19. Garrigue E, de Glisezinski I, Harant I, Moro C, Pillard F, Crampes F, Rivière D (2006) Métabolisme lipidique et exercice musculaire chez le sujet obèse. Sci Sports 21:68–73CrossRefGoogle Scholar
  20. Gayda M, Juneau M, Nigam A (2012) Comment on the paper by Gibala, Little, Macdonald and Hawley entitled physiological adaptations to low-volume, high intensity interval training in health and disease. J Physiol (Lond) 590:3389CrossRefGoogle Scholar
  21. Gibala M (2009) Molecular responses to high-intensity interval exercise. Appl Physiol Nutr Metab 34(3):428–432PubMedCrossRefGoogle Scholar
  22. Gibala MJ, Little JP, MacDonald MJ, Hawley JA (2012) Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol (Lond) 590:1077–1084. doi: 10.1113/jphysiol.2011.224725 CrossRefGoogle Scholar
  23. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH (2009) The incidence of comorbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 9:88PubMedCrossRefGoogle Scholar
  24. Gutin B, Yin Z, Humphries MC, Barbeau P (2005) Relations of moderate and vigorous physical activity to fitness and fatness in adolescents. Am J Clin Nutr 81:746–750PubMedGoogle Scholar
  25. Harriss DJ, Atkinson G (2011) Update ethical standards in sport and exercise science research. Int J Sports Med 32:819–821PubMedCrossRefGoogle Scholar
  26. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA et al (2007) Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 39(8):1423–1434PubMedCrossRefGoogle Scholar
  27. Hood MS, Little JP, Tarnopolsky MA, Myslik F, Gibala MJ (2011) Low-volume interval training improves muscle oxidative capacity in sedentary adults. Med Sci Sports Exerc 43:1849–1856. doi: 10.1249/MSS.0b013e3182199834 PubMedCrossRefGoogle Scholar
  28. Host HH, Hansen PA, Nolte LA, Chen MM, Holloszy JO (1998) Rapid reversal of adaptive increases in muscle GLUT-4 and glucose transport capacity after training cessation. J Appl Physiol 84:798–802PubMedGoogle Scholar
  29. Kiens B, Richter E (1998) Utilisation of skeletal muscle triacylglycerol during post-exercise recovery in humans. Am J Physiol Endocrinol Metab 275:E332–E337Google Scholar
  30. Koro CE, Bowlin SJ, Stump TE, Sprecher DL, Tierney WM (2006) The independent correlation between high-density lipoprotein cholesterol and subsequent major adverse coronary events. Am Heart J 151:755–756PubMedCrossRefGoogle Scholar
  31. Koubaa A, Trabelsi H, Masmoudi L, Elloumi M, Sahnoun Z, Zeghal KM, Hakim A (2013) Effect of Intermittent and continuous training on body composition cardio-respiratory fitness and lipid profile in obese adolescents. IOSR-JPBS 3(2):31–37Google Scholar
  32. Kuipers H, Verstappen FT, Keizer HA, Geurten P, Van Kranenburg G (1985) Variability of aerobic performance in the laboratory and its physiologic correlates. Int J Sports Med 6(4):197–201PubMedCrossRefGoogle Scholar
  33. Lamina S, Okoye GC (2012) Therapeutic effect of moderate intensity interval training program on the lipid profile in men with hypertension: a randomized controlled trial. Niger J Clin Pract 15(1):42–47PubMedCrossRefGoogle Scholar
  34. Little JP, Gillen JB, Percival ME, Safdar A, Tarnopolsky MA, Punthakee Z, Jung ME, Gibala MJ (2011) Low- volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol 111:1554–1560PubMedCrossRefGoogle Scholar
  35. McLaughlin JE, King GA, Howley ET, Bassett DR Jr, Ainsworth BE (2001) Validation of the cosmed K4b2 portable metabolic system. Int J Sports Med 22:280–284PubMedCrossRefGoogle Scholar
  36. Metcalfe RS, Babraj JA, Fawkner SG, Vollaard NB (2011) Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training. Eur J Appl Physiol. doi: 10.1007/s00421-011-2254-z PubMedGoogle Scholar
  37. Murakami T, Horigome H, Tanaka K, Nakata Y, Ohkawara K, Katayama Y, Matsui A (2007) Impact of weight reduction on production of platelet-derived micro-particles and fibrinolytic parameters in obesity. Thromb Res 119(1):45–53PubMedCrossRefGoogle Scholar
  38. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M et al (2005) Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 54:1472–1479PubMedCrossRefGoogle Scholar
  39. Pouliot MC, Despres JP, Lemieux S, Moorjani S, Bouchard C, Tremblay A, Nadeau A, Lupien PJ (1994) Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol 73:460–468PubMedCrossRefGoogle Scholar
  40. Punthakee Z, Delvin EE, O’Loughlin J (2006) Adiponectin, adiposity and insulin resistance in children and adolescents. J Clin Endocrinol Metab 91:2119–2125PubMedCrossRefGoogle Scholar
  41. Ratel S, Lazaar N, Dore E, Baquet G, Williams CA, Berthoin S, Van Praagh E, Bedu M, Duche P (2004) High- intensity intermittent activities at school: controversies and facts. J Sports Med Phys Fitness 44:272–280PubMedGoogle Scholar
  42. Rolland-Cachera MF, Cole TJ, Sempe′ M, Tichet J, Rossignol C, Charraud A (1991) Body mass index variations: centiles from birth to 87 yearth. Eur J Clin Nutr 45:13–21Google Scholar
  43. Saltin B, Gollnick PD (1983) Skeletal muscle adaptability: significance for metabolism and performance. In: Handbook of physiology skeletal muscle. American Physiological Society, Bethesda, pp 555–631 (sect 10)Google Scholar
  44. Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL (2007) Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol 102(4):1439–1447PubMedCrossRefGoogle Scholar
  45. Tanner JM, Whitehouse RH (1976) Clinical longitudinal standards for height, weight velocity and stages of puberty. Arch Dis Child 51:170–179PubMedCrossRefGoogle Scholar
  46. Tjonna AE, Lee SJ, Rognmo O, Stolen TO et al (2008) Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome—a pilot study. Circulation 118:346–354. doi: 10.1161/CIRCULATIONAHA.108.772822ER PubMedCrossRefGoogle Scholar
  47. Tjonna AE, Stolen TO, Bye A, Volden M, Slordahl SA, Odegard R, Skogvoll E, Wisloff U (2009) Aerobic interval training reduces cardiovascular risk factors more than a multi-treatment approach in overweight adolescents. Clin Sci 116:317–326PubMedCrossRefGoogle Scholar
  48. Whyte LJ, Gill JMR, Cathcart AJ (2010) Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight/obese men. Metabolism 59:1421–1428. doi: 10.1016/j.metabol.2010.01.002 Google Scholar
  49. Williams PT, Franklin B (2008) Relationship of running intensity to hypertension, hypercholesterolemia, and diabetes. Med Sci Sports Exerc 40(10):1740–1748PubMedCrossRefGoogle Scholar
  50. Woo KS, Chook P, Yu CW et al (2004) Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation 109:1981–1986PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • G. Racil
    • 1
    Email author
  • O. Ben Ounis
    • 2
  • O. Hammouda
    • 2
    • 3
  • A. Kallel
    • 4
  • H. Zouhal
    • 6
  • K. Chamari
    • 2
    • 5
  • M. Amri
    • 1
  1. 1.Department of Biological Sciences, Faculty of Science of TunisUniversity Tunis el ManarTunisTunisia
  2. 2.Higher Institute of Sport and Physical Education, Ksar Said in TunisUniversity of ManoubaTunisTunisia
  3. 3.Research Laboratory “Sport Performance Optimization”, National Center of Medicine and Sciences in Sport (CNMSS)TunisTunisia
  4. 4.Biochemistry Laboratory, CHU RabtaUniversity of Tunis El ManarTunisTunisia
  5. 5.Research and Education Centre, AspetarQatar Orthopaedic and Sports Medicine HospitalDohaQatar
  6. 6.Laboratoire Mouvement Sport Santé (M2S), UFR APSUniversité Rennes 2-ENS CachanRennes CedexFrance

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