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Effect of supplemental oxygen on post-exercise inflammatory response and oxidative stress

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Abstract

This investigation explored the influence of supplemental oxygen administered during the recovery periods of an interval-based running session on the post-exercise markers of reactive oxygen species (ROS) and inflammation. Ten well-trained male endurance athletes completed two sessions of 10 × 3 min running intervals at 85 % of the maximal oxygen consumption velocity (vVO2peak) on a motorised treadmill. A 90-s recovery period was given between each interval, during which time the participants were administered either a hyperoxic (HYP) (Fraction of Inspired Oxygen (FIO2) 99.5 %) or normoxic (NORM) (FIO2 21 %) gas, in a randomized, single-blind fashion. Pulse oximetry (SpO2), heart rate (HR), blood lactate (BLa), perceived exertion (RPE), and perceived recovery (TQRper) were recorded during each trial. Venous blood samples were taken pre-exercise, post-exercise and 1 h post-exercise to measure Interleukin-6 (IL-6) and Isoprostanes (F2-IsoP). The SpO2 was significantly lower than baseline following all interval repetitions in both experimental trials (p < 0.05). The SpO2 recovery time was significantly quicker in the HYP when compared to the NORM (p < 0.05), with a trend for improved perceptual recovery. The IL-6 and F2-IsoP were significantly elevated immediately post-exercise, but had significantly decreased by 1 h post-exercise in both trials (p < 0.05). There were no differences in IL-6 or F2-IsoP levels between trials. Supplemental oxygen provided during the recovery periods of interval based exercise improves the recovery time of SPO2 but has no effect on post-exercise ROS or inflammatory responses.

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Acknowledgments

The authors wish to acknowledge the grant funding received from the University of Western Australia’s Research Grant Scheme.

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Authors and Affiliations

  1. School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Australia

    Jodii White, Brian Dawson, Grant Landers & Peter Peeling

  2. Western Australian Institute of Sport. Mt Claremont, PO Box 139, Claremont, WA, 6910, Australia

    Peter Peeling

  3. School of Medicine and Pharmacology Royal Perth Hospital Unit, The University of Western Australia, Crawley, Australia

    Kevin Croft

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  1. Jodii White
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  2. Brian Dawson
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  3. Grant Landers
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  4. Kevin Croft
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  5. Peter Peeling
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Corresponding author

Correspondence to Peter Peeling.

Additional information

Communicated by Fabio Fischetti.

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White, J., Dawson, B., Landers, G. et al. Effect of supplemental oxygen on post-exercise inflammatory response and oxidative stress. Eur J Appl Physiol 113, 1059–1067 (2013). https://doi.org/10.1007/s00421-012-2521-7

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  • DOI: https://doi.org/10.1007/s00421-012-2521-7

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