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Skeletal muscle signaling response to sprint exercise in men and women

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Abstract

To determine if there is a sex dimorphism in the skeletal muscle signaling response to sprint exercise, 17 men and ten women performed a 30-s Wingate test. Muscle biopsies were taken before, immediately after the exercise and at 30 and 120 min during the recovery period. Thr172-AMPKα, Ser221-ACCβ, Thy705-STAT3, Thr202/Thy204-ERK1/2 and Thr180/Thy182-p38MAPK phosphorylation responses to sprint exercise were not statistically different between men and women. AMPKα phosphorylation was enhanced fourfold 30 min after the sprint exercise in males and females (P < 0.01). ACCβ phosphorylation was enhanced by about threefold just after the sprint test exercise and 30 min into the recovery period in males and females (P < 0.01). STAT3 phosphorylation was increased 2 h after the Wingate test compared to the value observed right after the end of the exercise (P < 0.05), and 30 min after the Wingate test there was a 2.5-fold increase in ERK1/2 phosphorylation, compared to both the pre-exercise and to the value observed right after the Wingate test (both, P < 0.05). In conclusion, the skeletal muscle signaling response to a single bout of sprint exercise mediated by AMPK, ACC, STAT3, ERK and p38MAPK is not statistically different between men and women. Marked increases in AMPKα, ACCβ, STAT3 and ERK phosphorylation were observed after a single 30-s all-out sprint (Wingate test) in the vastus lateralis.

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Acknowledgments

This study was supported by grants from the Ministerio de Educación y Ciencia (BFU2006-13784 and FEDER) and FUNCIS (PI/10/07), Proyecto Estructurante de la ULPGC: ULPAPD-08/01-4, Proyecto del Programa Propio de la ULPGC (ULPGC 2009-07), III Convocatoria de Ayudas a la Investigación Cátedra Real Madrid- UEM (2010/01RM, Universidad Europea de Madrid) and Ministerio de Ciencia e Innovación (DEP2010-21866). Our special thanks are given to José Navarro de Tuero and María Carmen García Chicano for their excellent technical assistance.

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  1. Department of Physical Education, Campus Universitario de Tafira s/n, University of Las Palmas de Gran Canaria, 35017, Las Palmas de Gran Canaria, Spain

    Teresa Fuentes, Borja Guerra, Jesús G. Ponce-González, David Morales-Alamo, Amelia Guadalupe-Grau, Hugo Olmedillas, Lorena Rodríguez-García, David Feijoo, Alfredo Santana & Jose A. L. Calbet

  2. Endocrinology Service, Hospital de Gran Canaria Dr. Negrín, Bco Ballena s/n, 35013, Las Palmas de Gran Canaria, Spain

    Pedro De Pablos-Velasco

  3. Department of Clinical Sciences, Molecular and Translational Endocrinology Group, University of Las Palmas de Gran Canaria, Dr. Pasteur s/n, Canary Islands, Spain

    Leandro Fernández-Pérez

  4. Genetic Unit, Childhood Hospital-Materno Infantil de Las Palmas, Avenida Marítima, del Sur s/n, 35016, Las Palmas de Gran Canaria, Spain

    Alfredo Santana

  5. Research Unit, Hospital de Gran Canaria Dr. Negrín, Bco Ballena s/n, 35013, Las Palmas de Gran Canaria, Spain

    Alfredo Santana

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  1. Teresa Fuentes
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Fuentes, T., Guerra, B., Ponce-González, J.G. et al. Skeletal muscle signaling response to sprint exercise in men and women. Eur J Appl Physiol 112, 1917–1927 (2012). https://doi.org/10.1007/s00421-011-2164-0

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