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Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults

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Abstract

Little is known if lifestyle-related risk factors modulate the adiponectin genetic effects on its outcome phenotypes. The aims of the study were to investigate whether the association between the adiponectin gene two SNPs (+45T>G, rs2241766 and +276G>T, rs1501299) and a clustering of metabolic risk factors is modified by both cardiorespiratory fitness (CRF) and insulin resistance in a study sample of 1,622 young Korean adults (941 men and 681 women, mean age 22.9 ± 2.4 years). The clustering of metabolic risk factors was defined as a sum of Z scores for waist circumference (WC), blood pressure (BP), triacylglycerols (TAG), high-density lipoprotein cholesterol, and fasting glucose. With respect to SNP +45T>G, the TT genotype had significantly higher values for BMI, WC, systolic BP, TAG, insulin, and a clustered risk score than did the TG+GG genotype. The genetic effect of SNP +45 on the clustered risk score remained significant even after controlling for age, sex, and smoking (P = 0.019). However, the genetic impact was no longer significant when additionally controlling for CRF (P = 0.097) and fasting insulin (P = 0.181), respectively. With respect to SNP +276G>T, the GT+TT genotypes had significantly higher values for BMI and TAG than did the TT genotype. In summary, the present findings suggest that the SNPs at position +45 and +276 are associated with several of metabolic risk factors; however, the genetic effect of SNP +45T/G variant on the clustered risk score is modulated by both CRF and insulin resistance.

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Acknowledgments

This study was supported by a Korean Research Foundation grant funded by the Korean Government (MOEHRD) (KRF-2008-321-G00024).

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The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Pohang University of Science and Technology, Pohang, Republic of Korea

    Ji-Young Lee

  2. School of Sport Science, Sungkyunkwan University, 300 Chenchen-dong, Jangan-Gu, Suwon, 440-746, Republic of Korea

    Jin-Kyung Cho, Hye-Ryun Hong, Young-Yoon Jin & Hyun-Sik Kang

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  1. Ji-Young Lee
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  2. Jin-Kyung Cho
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  3. Hye-Ryun Hong
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  4. Young-Yoon Jin
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Correspondence to Hyun-Sik Kang.

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Communicated by Susan A. Ward.

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Lee, JY., Cho, JK., Hong, HR. et al. Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults. Eur J Appl Physiol 112, 623–629 (2012). https://doi.org/10.1007/s00421-011-2015-z

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  • DOI: https://doi.org/10.1007/s00421-011-2015-z

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