Abstract
Estrogen receptors in skeletal muscle suggest a tissue-based mechanism for influencing neuromuscular control. This has important physiological implications for both eumenorrheic women with fluctuating estrogen levels and those with constant and attenuated estrogen levels, i.e., women using the monophasic oral contraceptive pill (MOCP). This study examined the effects of endogenous plasma estrogen levels on leg stiffness (K LEG) and foot center of pressure (COP) during hopping. Nineteen females (Age = 28.0 ± 4.2 years, Ht = 1.67 ± 0.07 m, Mass = 61.6 ± 6.8 kg) who had been using the MOCP for at least 12 months together with 19 matched, female, non-MOCP users (Age = 31.9 ± 7.3 years, Ht = 1.63 ± 0.05 m, Mass = 62.5 ± 5.9 kg) participated. Non-MOCP users were tested at the time of lowest (menstruation) and highest (≈ovulation) estrogen whilst MOCP users were tested at Day 1 and Day 14 of their cycle. At each test session, K LEG (N m−1 kg−1) and foot COP path length (mm) and path velocity (mm s−1) were determined from ground reaction force data as participants hopped at 2.2 Hz on a force plate. Statistical analysis revealed no significant (p < 0.05) differences for K LEG. In contrast, significantly higher COP path length (30%) and COP path velocity (25%) were identified at ≈ovulation compared to menstruation in the non-MOCP users. Whilst there was no evidence of an estrogen-induced effect on K LEG; significantly elevated estrogen at ≈ovulation presumably increased extensibility of connective tissue and/or diminished neuromuscular control. Consistent lower limb dynamics of MOCP users demands less reliance on acutely modified neuromuscular control strategies during dynamic tasks and may explain the lower rate of lower limb musculoskeletal injuries in this population compared to non-MOCP users.
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References
Agel J, Bershadsky B, Arendt EA (2006) Hormonal therapy: ACL and ankle injury. Med Sci Sports Exerc 38:7–12
Alnaqueeb MA, Goldspink G (1986) Changes in fiber type, number and diameter in aging muscles. J Anat 152:31–45
Arendt EA, Bershadsky B, Agel J (2002) Periodicity of noncontact anterior cruciate ligament injuries during the menstrual cycle. J Gend Specif Med 5:19–26
Bradley M, Schumann B (1984) Examination of urine. In: Henry JB (ed) Clinical diagnosis and management by laboratory methods. WB Saunders Co, Philadelphia, pp 380–387
Bryant AL, Clark RA, Bartold S, Murphy A, Bennell KL, Hohmann E, Marshall-Gradisnik S, Payne C, Crossley KM (2008) Effects of estrogen on the mechanical behavior of the human Achilles tendon in vivo. J Appl Physiol 105:1035–1043
Bush IE (1961) Determination of estrogens, androgens, progesterone, and related steroids in human plasma and urine. In: Bush IE (ed) The chromotography of steroids. Pergamon Press, New York, pp 57–139
Cai W, Rambaud J, Teboul M, Masse I, Benoit G, Gustafsson JA, Delaunay F, Laudet V, Pongratz I (2008) Expression levels of estrogen receptor beta are modulated by components of the molecular clock. Mol Cell Biol 28:784–793
Cavagna G (1975) Force platforms as ergometers. J Appl Physiol 39:174–179
Clark R, Child S, Crossley K, Bryant AL (2007) Reliability of an in vivo measure of Achilles tendon strain. J Sci Med Sport 10:78
Clark RA, Bartold S, Bryant AL (2010) Tibial acceleration variability during consecutive gait cycles is influenced by the menstrual cycle. Clin Biomech (Bristol, Avon) 25:557–562
Darlington CL, Ross A, King J, Smith PF (2001) Menstrual cycle effects on postural stability but not optokinetic function. Neurosci Lett 307:147–150
Dedrick GS, Sizer PS, Merkle JN, Hounshell TR, Robert-McComb JJ, Sawyer SF, Brismee JM, Roger James C (2008) Effect of sex hormones on neuromuscular control patterns during landing. J Electromyogr Kinesiol 18:68–78
Eiling E, Bryant AL, Petersen W, Murphy A, Hohmann E (2007) Effects of menstrual-cycle hormone fluctuations on musculotendinous stiffness and knee joint laxity. Knee Surg Sports Traumatol Arthrosc 15:126–132
Elliott KJ, Cable NT, Reilly T (2005) Does oral contraceptive use affect maximum force production in women? Br J Sports Med 39:15–19
Farley CT, Gonzalez O (1996) Leg stiffness and stride frequency in human running. J Biomech 29:181–186
Farley CT, Blickhan R, Saito J, Taylor CR (1991) Hopping frequency in humans: a test of how springs set stride frequency in bouncing gaits. J Appl Physiol 71:2127–2132
Ferin MJ (1996) The menstrual cycle: an integrative view. In: Adashi EY, Rock JA, Rosenwaks Z (eds) Reproductive endocrinology, surgery and technology. Lippincott-Raven, Philadelphia, p 106
Ferris DP, Farley CT (1997) Interaction of leg stiffness and surface stiffness during human hopping. J Appl Physiol 82:15–22
Friden C, Hirschberg AL, Saartok T, Backstrom T, Leanderson J, Renstrom P (2003) The influence of premenstrual symptoms on postural balance and kinesthesia during the menstrual cycle. Gynecol Endocrinol 17:433–439
Greene PR, McMahon TA (1979) Reflex stiffness of man’s anti-gravity muscles during kneebends while carrying extra weights. J Biomech 12:881–891
Heitz NA, Eisenman PA, Beck CL, Walker JA (1999) Hormonal changes throughout the menstrual cycle and increased anterior cruciate ligament laxity in females. J Athl Train 34:144–149
Huijing PA, Jaspers RT (2005) Adaptation of muscle size and myofascial force transmission: a review and some new experimental results. Scand J Med Sci Sports 15:349–380
Karageanes SJ, Blackburn K, Vangelos ZA (2000) The association of the menstrual cycle with the laxity of the anterior cruciate ligament in adolescent female athletes. Clin J Sport Med 10:162–168
Kearney RE, Hunter IW (1990) System identification of human joint dynamics. Crit Rev Biomed Eng 18:55–87
Lee CY, Liu X, Smith CL, Zhang X, Hsu HC, Wang DY, Luo ZP (2004) The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament. Matrix Biol 23:323–329
Lemoine S, Granier P, Tiffoche C, Rannou-Bekono F, Thieulant ML, Delamarche P (2003) Estrogen receptor alpha mRNA in human skeletal muscles. Med Sci Sports Exerc 35:439–443
Lloyd RS, Oliver JL, Hughes MG, Williams CA (2009) Reliability and validity of field-based measures of leg stiffness and reactive strength index in youths. J Sports Sci 27:1565–1573
McMahon TA, Cheng GC (1990) The mechanics of running: how does stiffness couple with speed? J Biomech 23(Suppl 1):65–78
Nigg BM, Wakeling JM (2001) Impact forces and muscle tuning: a new paradigm. Exerc Sport Sci Rev 29:37–41
Posthuma BW, Bass MJ, Bull SB, Nisker JA (1987) Detecting changes in functional ability in women with premenstrual syndrome. Am J Obstet Gynecol 156:275–278
Queen RM, Abbey AN, Wiegerinck JI, Yoder JC, Nunley JA (2010) Effect of shoe type on plantar pressure: a gender comparison. Gait Posture 31:18–22
Romani W, Curl LA, Lovering R (2001) The effect of endogenous estradiol levels at three phases of the menstrual cycle on anterior cruciate ligament stiffness in active females. J Athl Train 2:S62
Ross SE, Guskiewicz KM, Gross MT, Yu B (2009) Balance measures for discriminating between functionally unstable and stable ankles. Med Sci Sports Exerc 41:399–407
van den Heuvel MW, van Bragt AJ, Alnabawy AK, Kaptein MC (2005) Comparison of ethinylestradiol pharmacokinetics in three hormonal contraceptive formulations: the vaginal ring, the transdermal patch and an oral contraceptive. Contraception 72:168–174
Woolley CS (1999) Effects of estrogen in the CNS. Curr Opin Neurobiol 9:349–354
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Communicated by Jean-René Lacour.
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Bryant, A.L., Crossley, K.M., Bartold, S. et al. Estrogen-induced effects on the neuro-mechanics of hopping in humans. Eur J Appl Physiol 111, 245–252 (2011). https://doi.org/10.1007/s00421-010-1647-8
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DOI: https://doi.org/10.1007/s00421-010-1647-8