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European Journal of Applied Physiology

, Volume 111, Issue 3, pp 403–420 | Cite as

Disuse of the musculo-skeletal system in space and on earth

  • M. V. Narici
  • M. D. de Boer
Original Article

Abstract

Muscle mass and strength are well known to decline in response to actual and simulated microgravity exposure. However, despite the considerable knowledge gained on the physiological changes induced by spaceflight, the mechanisms of muscle atrophy and the effectiveness of in-flight countermeasures still need to be fully elucidated. The present review examines the effects and mechanisms of actual and simulated microgravity on single fibre and whole muscle structural and functional properties, protein metabolism, tendon mechanical properties, neural drive and reflex excitability. The effects of inflight countermeasures are also discussed in the light of recent advances in resistive loading techniques, in combined physical, pharmacological and nutritional interventions as well as in the development of artificial gravity systems. Emphasis has been given to the pioneering work of Pietro Enrico di Prampero in the development of artificial gravity systems and in the progress of knowledge on the limits of human muscular performance in space.

Keywords

Skeletal muscle Microgravity Spaceflight Countermeasures Atrophy 

Notes

Acknowledgments

A significant portion of this Review paper makes direct reference to published literature of Prof. PE di Prampero and co-workers and indirectly, to work performed through the close and most enjoyable collaboration we shared over the last 30 years. We are also grateful to the funding agencies that partly supported this work (ESA, ASI and the Slovenian Ministry of Defence) and to Prof. Rado Pisot (University of Primorska, Science and Research Centre Koper, Institute for Kinesiology Research, Slovenia) for creating the opportunity for performing some of the ground-based studies cited in this paper.

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© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Institute for Biomedical Research into Human Movement and Health, Faculty of Science and EngineeringManchester Metropolitan UniversityManchesterUK
  2. 2.Division of Applied Medicine, School of Medicine and DentistryUniversity of AberdeenScotlandUK

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