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Influence of age, sex, and aerobic capacity on forearm and skin blood flow and vascular conductance

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Abstract

This study investigated the influence of age, sex, and aerobic capacity on resting and peak forearm and cutaneous blood flow (FBF, CBF). We recruited 93 female and 129 male subjects (age range 16–76 years). FBF and CBF were assessed by plethysmography and laser-Doppler flowmetry, respectively. Peak FBF was obtained following 5 min forearm vascular occlusion and peak CBF in response to local skin heating of 42°C. Blood pressure was measured manually and by Finapres. Maximal oxygen uptake (VO2max) was obtained from a treadmill exercise stress test. Age was associated with declines in resting FBF (y = −1.176 ln(x) + 6.6899, r 2 = 0.45) and peak FBF (y = −17.21 ln(x) + 93.843, r 2 = 0.53) (both p < 0.05). Peak CBF decreased with increasing age (y = −223.6 ln(x) + 1,102.9, r 2 = 0.34) (p < 0.05), but resting CBF was unchanged (p > 0.05). Males had higher resting and peak FBF than females (p < 0.05) and these variables were related to ageing better in males (y = −1.245 ln(x) + 7.188, r 2 = 0.71 and y = −18.53 ln(x) + 102.82, r 2 = 0.69) than in females (y = −1.149 ln(x) + 6.4307, r 2 = 0.38 and y = −16.59 ln(x) + 88.872, r 2 = 0.55). There were no sex differences in resting CBF (p > 0.05). Peak CBF was much better related to ageing in males than females (y = −276.1 ln(x) + 1,365.4, r 2 = 0.53 vs. y = −183.1 ln(x) + 907.86, r 2 = 0.28). VO2max decreased with advancing age and this decline was associated with the decline in peak FBF (y = −0.5933x + 10.91, r 2 = 0.36, p < 0.05) but not with peak CBF (p > 0.05). These results suggest that healthy ageing is associated with a curvilinear decline in resting and peak forearm and peak cutaneous vasodilator capacity, with males more severely affected than females. The data indicate that peak FBF is influenced by VO2max but peak CBF is not.

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Acknowledgments

We thank the subjects for their participation in the study. Dr. Hodges is now at The University of Western Ontario. Dr. Clements is now at The University of Chichester. This study was supported by the Dunhill Medical Trust, R-36455.

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Authors and Affiliations

  1. Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, Henry Cotton Campus, Webster Street, Liverpool, L3 2ET, UK

    Gary J. Hodges, Lisa Sharp, Richard E. Clements, David F. Goldspink, Keith P. George & Nigel T. Cable

  2. School of Kinesiology, University of Western Ontario, London, ON, N6A 3K7, Canada

    Gary J. Hodges

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  1. Gary J. Hodges
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  2. Lisa Sharp
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  3. Richard E. Clements
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  5. Keith P. George
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  6. Nigel T. Cable
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Correspondence to Gary J. Hodges.

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Communicated by Niels Secher.

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Hodges, G.J., Sharp, L., Clements, R.E. et al. Influence of age, sex, and aerobic capacity on forearm and skin blood flow and vascular conductance. Eur J Appl Physiol 109, 1009–1015 (2010). https://doi.org/10.1007/s00421-010-1441-7

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  • DOI: https://doi.org/10.1007/s00421-010-1441-7

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