Abstract
To evaluate the possibility of using near-infrared spectroscopy (NIRS) to measure tissue oxygenation (StO2) during hyperbaric oxygen (HBO) therapy. Nine healthy volunteers (1 female) age 25−37 years, breathed air or oxygen. Tissue oxygenation was measured using NIRS on the thumb. Subjects were blinded to breathing gas. A range of partial pressures of oxygen were administered in 10-min intervals: 21, 101, 21 kPa (compression to 280 kPa), 59, 280, 59 (decompression), 21 kPa. Data were averaged over last 5 min at each pressure. When switching from air to normobaric oxygen (NBO 101 kPa) StO2 increased from 83% (82−85%, median and interquartile range) to 85% (84−87%) (P < 0.01), while when switching from air at pressure (59 kPa O2) to HBO (280 kPa), StO2 increased from 85% (85−86%) to 88% (87−89%) (P < 0.001). There was no difference between baseline StO2 while air breathing before NBO or after decompression. Values did not reach the maximal value of 100% at any point. The changes in hemoglobin oxygen saturation in tissue registered by the NIRS monitor when switching from air to oxygen followed inspired PO2 under normobaric and hyperbaric conditions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boushel RLH, Olesen J, Gonzales-Alonzo J, Bülow J, Kjær M (2001) Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease. Scand J Med Sci Sports 11:213–222
Creteur J, Carollo T, Soldati G, Buchele G, De Backer D, Vincent JL (2007) The prognostic value of muscle StO2 in septic patients. Intensive Care Med 33:1549–1556
Gesell L (ed) (2008) Hyperbaric oxygen therapy indications. Undersea and Hyperbaric Medical Society, Durham, NC. ISBN: 0-930406-23-0
Gomez H, Torres A, Polanco P, Kim HK, Zenker S, Puyana JC, Pinsky MR (2008) Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O(2) saturation response. Intensive Care Med 34:1600–1607
Greisen G (2006) Is near-infrared spectroscopy living up to its promises? Semin Fetal Neonatal Med 11:498–502
Kragelj R, Jarm T, Miklavcic D (2000) Reproducibility of parameters of postocclusive reactive hyperemia measured by near infrared spectroscopy and transcutaneous oximetry. Ann Biomed Eng 28:168–173
Kurschel S, Mohia A, Weigl V, Eder HG (2006) Hyperbaric oxygen therapy for the treatment of brain abscess in children. Childs Nerv Syst 22:38–42
Ledermann HP, Heidecker HG, Schulte AC, Thalhammer C, Aschwanden M, Jaeger KA, Scheffler K, Bilecen D (2006) Calf muscles imaged at BOLD MR: correlation with TcPO2 and flowmetry measurements during ischemia and reactive hyperemia—initial experience. Radiology 241:477–484
Litscher G, Schwarz G, Ratzenhofer-Komenda B, Kovac H, Gabor S, Smolle-Juttner FM (1997) Transcranial cerebral oximetry in the hyperbaric environment. Biomed Tech 42:38–41
Mathieu D, Mani R (2007) A review of the clinical significance of tissue hypoxia measurements in lower extremity wound management. Int J Low Extrem Wounds 6:273–283
Nagdyman N, Fleck T, Schubert S, Ewert P, Peters B, Lange PE, Abdul-Khaliq H (2005) Comparison between cerebral tissue oxygenation index measured by near-infrared spectroscopy and venous jugular bulb saturation in children. Intensive Care Med 31:846–850
Nagdyman N, Ewert P, Peters B, Miera O, Fleck T, Berger F (2008) Comparison of different near-infrared spectroscopic cerebral oxygenation indices with central venous and jugular venous oxygenation saturation in children. Paediatr Anaesth 18:160–166
Acknowledgments
Stockholm City Council has supported this study. Jorge Rodrigues Inacio, Chief Engineer, and Hanan Taslimi, Engineer, Medical Technical Department of Karolinska University Hospital, have assisted in producing a test protocol for and testing equipment for this study.
Author information
Authors and Affiliations
Corresponding author
Additional information
Communicated by Susan Ward.
Rights and permissions
About this article
Cite this article
Larsson, A., Uusijärvi, J., Eksborg, S. et al. Tissue oxygenation measured with near-infrared spectroscopy during normobaric and hyperbaric oxygen breathing in healthy subjects. Eur J Appl Physiol 109, 757–761 (2010). https://doi.org/10.1007/s00421-010-1403-0
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00421-010-1403-0