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Enhancement of the finger cold-induced vasodilation response with exercise training

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Cold-induced vasodilatation (CIVD) is a cyclical increase in finger temperature that has been suggested to provide cryoprotective function during cold exposures. Physical fitness has been suggested as a potential factor that could affect CIVD response, possibly via central (increased cardiac output, decreased sympathetic nerve activity) and/or peripheral (increased microcirculation) cardiovascular and neural adaptations to exercise training. Therefore, the purpose of this study was to investigate the effect of endurance exercise training on the CIVD response. Eighteen healthy males trained 1 h d−1 on a cycle ergometer at 50% of peak power output, 5 days week−1 for 4-weeks. Pre, Mid, Post, and 10 days after the cessation of training and on separate days, subjects performed an incremental exercise test to exhaustion \( (\mathop V\limits^{ \cdot }\!\! {\text{O}}_{{2{\text{peak}}}} ), \) and a 30-min hand immersion in 8°C water to examine their CIVD response. The exercise-training regimen significantly increased \( \mathop V\limits^{ \cdot }\!\!{\text{O}}_{{2{\text{peak}}}} \) (Pre: 46.0 ± 5.9, Mid: 52.5 ± 5.7, Post: 52.1 ± 6.2, After: 52.6 ± 7.6 ml kg−1 min−1; P < 0.001). There was a significant increase in average finger skin temperature (Pre: 11.9 ± 2.4, After: 13.5 ± 2.5°C; P < 0.05), the number of waves (Pre: 1.1 ± 1.0, After: 1.7 ± 1.1; P < 0.001) and the thermal sensation (Pre: 1.7 ± 0.9, After: 2.5 ± 1.4; P < 0.001), after training. In conclusion, the aforementioned endurance exercise training significantly improved the finger CIVD response during cold-water hand immersion.

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  • Amann M, Romer LM, Pegelow DF, Jacques AJ, Hess CJ, Dempsey JA (2006) Effects of arterial oxygen content on peripheral locomotor muscle fatigue. J Appl Physiol 101:119–127

    Article  PubMed  Google Scholar 

  • Bergersen TK, Hisdal J, Walloe L (1999) Perfusion of the human finger during cold-induced vasodilatation. Am J Physiol 276:R731–R737

    CAS  PubMed  Google Scholar 

  • Borg G (1998) Borg’s perceived exertion and pain scales. Human Kinetics, Champaign

    Google Scholar 

  • Brown GM, Page J (1952) The effect of chronic exposure to cold on temperature and blood flow of the hand. J Appl Physiol 5:221–227

    CAS  PubMed  Google Scholar 

  • Cheung SS, Mekjavic IB (2007) Cold-induced vasodilatation is not homogenous or generalizable across the hand and feet. Eur J Appl Physiol 99:701–705

    Article  PubMed  Google Scholar 

  • Cullinane EM, Sady SP, Vadeboncoeur L, Burke M, Thompson PD (1986) Cardiac size and VO2max do not decrease after short-term exercise cessation. Med Sci Sports Exerc 18:420–424

    CAS  PubMed  Google Scholar 

  • Daanen HA (2003) Finger cold-induced vasodilation: a review. Eur J Appl Physiol 89:411–426

    Article  CAS  PubMed  Google Scholar 

  • Daanen HA, Ducharme MB (1999) Finger cold-induced vasodilation during mild hypothermia, hyperthermia and at thermoneutrality. Aviat Space Environ Med 70:1206–1210

    CAS  PubMed  Google Scholar 

  • Dobnikar U, Kounalakis SN, Mekjavic IB (2009) The effect of exercise-induced elevation in core temperature on cold-induced vasodilatation response in toes. Eur J Appl Physiol 106:457–464

    Article  PubMed  Google Scholar 

  • Duncan JJ, Farr JE, Upton SJ, Hagan RD, Oglesby ME, Blair SN (1985) The effects of aerobic exercise on plasma catecholamines and blood pressure in patients with mild essential hypertension. JAMA 254:2609–2613

    Article  CAS  PubMed  Google Scholar 

  • Ekblom B, Hermansen L (1968) Cardiac output in athletes. J Appl Physiol 25:619–625

    CAS  PubMed  Google Scholar 

  • Felicijan A, Golja P, Milcinski M, Cheung SS, Mekjavic IB (2008) Enhancement of cold-induced vasodilatation following acclimatization to altitude. Eur J Appl Physiol 104:201–206

    Article  PubMed  Google Scholar 

  • Flouris AD, Cheung SS (2009) Influence of thermal balance on cold-induced vasodilation. J Appl Physiol 106:1264–1271

    Article  PubMed  Google Scholar 

  • Flouris AD, Westwood DA, Mekjavic IB, Cheung SS (2008) Effect of body temperature on cold induced vasodilation. Eur J Appl Physiol 104:491–499

    Article  PubMed  Google Scholar 

  • Grassi G, Seravalle G, Calhoun DA, Mancia G (1994) Physical training and baroreceptor control of sympathetic nerve activity in humans. Hypertension 23:294–301

    CAS  PubMed  Google Scholar 

  • Huonker M, Halle M, Keul J (1996) Structural and functional adaptations of the cardiovascular system by training. Int J Sports Med 17(Suppl 3):S164–S172

    Article  CAS  PubMed  Google Scholar 

  • Kuipers H, Verstappen FT, Keizer HA, Geurten P, van Kranenburg G (1985) Variability of aerobic performance in the laboratory and its physiologic correlates. Int J Sports Med 6:197–201

    Article  CAS  PubMed  Google Scholar 

  • Lenasi H, Strucl M (2004) Effect of regular physical training on cutaneous microvascular reactivity. Med Sci Sports Exerc 36:606–612

    Article  PubMed  Google Scholar 

  • Lewis T (1930) Observations upon the reactions of the vessels of the human skin to cold. Heart 15:177–208

    Google Scholar 

  • Liu JL, Irvine S, Reid IA, Patel KP, Zucker IH (2000) Chronic exercise reduces sympathetic nerve activity in rabbits with pacing-induced heart failure: a role for angiotensin II. Circulation 102:1854–1862

    CAS  PubMed  Google Scholar 

  • Livingstone SD (1976) Changes in cold-induced vasodilation during Arctic exercises. J Appl Physiol 40:455–457

    CAS  PubMed  Google Scholar 

  • Maiorana A, O’Driscoll G, Taylor R, Green D (2003) Exercise and the nitric oxide vasodilator system. Sports Med 33:1013–1035

    Article  PubMed  Google Scholar 

  • Masashi SYM, Akihiro T (2004) Effects of exercise on cold-induced vasodilation in young women. Jpn J Phys Fit Sports Med 53:293–299

    Google Scholar 

  • McCarthy PW, Heusch AI (2006) The vagaries of ear temperature assessment. J Med Eng Technol 30:242–251

    Article  CAS  PubMed  Google Scholar 

  • McDonald MP, Sanfilippo AJ, Savard GK (1993) Baroreflex function and cardiac structure with moderate endurance training in normotensive men. J Appl Physiol 74:2469–2477

    CAS  PubMed  Google Scholar 

  • Meehan JP Jr (1955) Individual and racial variations in a vascular response to a cold stimulus. Mil Med 116:330–334

    PubMed  Google Scholar 

  • Mekjavic IB, Sun J, Lun V, Giesbrecht G (1992) Evaluation of an infra-red tympanic thermometer during cold water immersion and rewarming. In: ILWHG (ed) Proceedings of the 5th international conference on environmental ergonomics, Maastricht, The Netherlands, p 1

  • Mekjavic IB, Dobnikar U, Kounalakis SN, Musizza B, Cheung SS (2008) The trainability and contralateral response of cold-induced vasodilatation in the fingers following repeated cold exposure. Eur J Appl Physiol 104:193–199

    Article  PubMed  Google Scholar 

  • Moriya K, Nakagawa K (1990) Cold-induced vasodilatation of finger and maximal oxygen consumption of young female athletes born in Hokkaido. Int J Biometeorol 34:15–19

    Article  CAS  PubMed  Google Scholar 

  • O’ Brien CCJ, Young AJ (1999) Exrtional fatigue alters cold-induced vasodilation. Med Sci Sports Exerc 31(Suppl):894

    Google Scholar 

  • Reynolds LF, Mekjavic IB, Cheung SS (2007) Cold-induced vasodilatation in the foot is not homogenous or trainable over repeated cold exposure. Eur J Appl Physiol 102:73–78

    Article  PubMed  Google Scholar 

  • Romanovsky AA, Quint PA, Benikova Y, Kiesow LA (1997) A difference of 5 degrees C between ear and rectal temperatures in a febrile patient. Am J Emerg Med 15:383–385

    Article  CAS  PubMed  Google Scholar 

  • Whyte GP, George K, Shave R, Middleton N, Nevill AM (2008) Training induced changes in maximum heart rate. Int J Sports Med 29:129–133

    Article  CAS  PubMed  Google Scholar 

  • Wilson O, Goldman RF (1970) Role of air temperature and wind in the time necessary for a finger to freeze. J Appl Physiol 29:658–664

    CAS  PubMed  Google Scholar 

  • Zhang H, Huizenga C, Arens E, Wang D (2004) Thermal sensation and comfort in transient non-uniform thermal environments. Eur J Appl Physiol 92:728–733

    Article  CAS  PubMed  Google Scholar 

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The current study was funded, in part, by the Olympic Committee of Slovenia, and by a “Knowledge for Security and Peace” grant from the Ministry of Defense (Republic of Slovenia). We would like to thank all the subjects for their participation. We are also grateful to Mojca Amon, Tadej Debevec, and Bostjan Simunic for their technical assistance.

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Correspondence to Michail E. Keramidas.

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Communicated by Nigel Taylor.

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Keramidas, M.E., Musizza, B., Kounalakis, S.N. et al. Enhancement of the finger cold-induced vasodilation response with exercise training. Eur J Appl Physiol 109, 133–140 (2010).

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