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Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight

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Abstract

The influence of a proprietary blend of modified cellulose and cetylated fatty acids (Trisynex™, Imagenetix, Inc., San Diego, CA 92127, USA) on adipocytokine and regional body composition responses to a weight loss program was examined. Twenty-two women (Supplement group (S) (n = 11): age = 36.8 ± 7.2 years; weight = 87.1 ± 6.2 kg; % body fat = 43.4 ± 4.1; Placebo group (P) (n = 11): age = 38.3 ± 6.8 years; weight = 86.9 ± 4.7 kg; % body fat = 44.3 ± 2.0) completed an 8-week placebo-controlled, double-blind study consisting of a caloric restricted diet and cardiovascular exercise. Body composition and serum insulin, leptin, and adiponectin were assessed at pre-, mid-, and post-intervention. From pre- to post-intervention, significant decreases (P < 0.05) were observed for body weight (S: 87.1 ± 6.2–77.9 ± 5.1 kg; P: 86.9 ± 4.7–82.7 ± 3.8 kg) (P < 0.05 S vs. P), % body fat (S: 43.4 ± 4.1–36.1 ± 3.6; P: 44.3 ± 2.0–40.6 ± 1.2) (P < 0.05 S vs. P), leptin (S: 28.3 ± 3.5–16.2 ± 2.6 ng ml−1; P: 29.4 ± 3.2–19.9 ± 1.1 ng ml−1) (P < 0.05 S vs. P), and insulin (S: 7.3 ± 0.8–5.1 ± 0.2 mU l−1; P: 7.7 ± 0.9–5.1 ± 0.3 mU l−1). Serum adiponectin increased (P < 0.05) (S: 12.2 ± 2.4–26.3 ± 3.0 μg ml−1: 12.6 ± 2.0–21.8 ± 3.1 μg ml−1) (P < 0.05 for S vs. P). Supplementation with a proprietary blend of modified cellulose and cetylated fatty acids during an 8-week weight loss program exhibited favorable effects on adipocytokines and regional body composition.

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Acknowledgments

We want to thank a dedicated group of participants and also our laboratory, training and medical staff that made this study possible. This study was funded in part by a corporate grant from Imagenetix, Inc., San Diego, CA 92127 which is also was the proprietary owner of the supplement.

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Authors and Affiliations

  1. Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT, 06269, USA

    Maren S. Fragala, William J. Kraemer, Jeff S. Volek, Carl M. Maresh, Michael J. Puglisi, Jakob L. Vingren, Jen-Yu Ho, Disa L. Hatfield, Barry A. Spiering, Cassandra E. Forsythe, Gwendolyn A. Thomas, Erin E. Quann & Jeffrey M. Anderson

  2. Research and Development, Imagenetix, Inc., San Diego, CA, 92127, USA

    Robert L. Hesslink Jr

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  1. Maren S. Fragala
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  2. William J. Kraemer
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  4. Carl M. Maresh
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Correspondence to William J. Kraemer.

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Fragala, M.S., Kraemer, W.J., Volek, J.S. et al. Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight. Eur J Appl Physiol 105, 665–672 (2009). https://doi.org/10.1007/s00421-008-0944-y

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