Abstract
Numerous studies have shown significant effects of weightlessness on adaptational processes of the CNS, cardiovascular and/or muscular system. Most of these studies have been carried out during parabolic flights, using the recurring 20 s of weightlessness at each parabola. Although some of these studies reported on potential influences not only of weightlessness but also of the stressful situation within a parabolic flight, especially provoked by the ongoing changes between 1.8, 1 and 0 G, so far there seems to be only marginal information about objective parameters of stress evoked by parabolic flights. By collecting blood samples from a permanent venous catheter several times during parabolic flights, we were able to show an increase of prolactin, cortisol and ACTH in the course of a 120 min flight. We conclude, therefore, that previous reported effects of weightlessness on adaptational processes may be affected not only by weightlessness but also by the exposure to other stressors experienced within the environment of a Zero-G airbus.
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References
Augurelle AS, Penta M, White O, Thonnard JL (2003) The effects of a change in gravity on the dynamics of prehension. Exp Brain Res 148:533–540
Blogg SL, Gennser M (2006) Cerebral blood flow velocity and psychomotor performance during acute hypoxia. Aviat Space Environ Med 77:107–113
Bock O, Fowler B, Comfort D (2001) Human sensorimotor coordination during spaceflight: an analysis of pointing and tracking responses during the “Neurolab” Space Shuttle mission. Aviat Space Environ Med 72:877–883
Bock O, Abeele S, Eversheim U (2003) Sensorimotor performance and computational demand during short-term exposure to microgravity. Aviat Space Environ Med 74:1256–1262
Buchanan TW, Lovallo WR (2001) Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology 26:307–317
Cahill L, Alkire MT (2003) Epinephrine enhancement of human memory consolidation: interaction with arousal at encoding. Neurobiol Learn Mem 79:194–198
Charmandari E, Tsigos C, Chrousos G (2005) Endocrinology of the stress response. Annu Rev Physiol 67:259–284
Chrousos GP, Gold PW (1992) The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267:1244–1252
Courtney CH, McAllister AS, McCance DR, Bell PM, Hadden DR, Leslie H, Sheridan B, Atkinson AB (2000) Comparison of one week 0900 h serum cortisol, low and standard dose synacthen tests with a 4 to 6 week insulin hypoglycaemia test after pituitary surgery in assessing HPA axis. Clin Endocrinol (Oxf) 53:431–436
Crofton PM, Midgley PC (2004) Cortisol and growth hormone responses to spontaneous hypoglycaemia in infants and children. Arch Dis Child 89:472–478
Diver MJ, Hughes JG, Hutton JL, West CR, Hipkin LJ (1994) The long-term stability in whole blood of 14 commonly-requested hormone analytes. Ann Clin Biochem 31(Pt6):561–565
Drummer C, Stromeyer H, Riepl RL, Konig A, Strollo F, Lang RE, Maass H, Rocker L, Gerzer R (1990) Hormonal changes after parabolic flight: implications on the development of motion sickness. Aviat Space Environ Med 61:821–828
Ellis MJ, Livesey JH, Evans MJ (2003) Hormone stability in human whole blood. Clin Biochem 36:109–112
Elzinga BM, Roelofs K (2005) Cortisol-induced impairments of working memory require acute sympathetic activation. Behav Neurosci 119:98–103
Evans MJ, Livesey JH, Ellis MJ, Yandle TG (2001) Effect of anticoagulants and storage temperatures on stability of plasma and serum hormones. Clin Biochem 34:107–112
Eversmann T, Gottsmann M, Uhlich E, Ulbrecht G, von Werder K, Scriba PC (1978) Increased secretion of growth hormone, prolactin, antidiuretic hormone, and cortisol induced by the stress of motion sickness. Aviat Space Environ Med 49:53–57
Farrace S, Biselli R, Urbani L, Ferlini C, De Angelis C (1996) Evaluation of stress induced by flight activity by measuring the hormonal response. Biofeedback Self Regul 21:217–228
Fowler B, Manzey D (2000) Summary of research issues in monitoring of mental and perceptual-motor performance and stress in space. Aviat Space Environ Med 71:A76–A77
Fowler B, Comfort D, Bock O (2000) A review of cognitive and perceptual-motor performance in space. Aviat Space Environ Med 71:A66–A68
Gerra G, Zaimovic A, Mascetti GG, Gardini S, Zambelli U, Timpano M, Raggi MA, Brambilla F (2001) Neuroendocrine responses to experimentally-induced psychological stress in healthy humans. Psychoneuroendocrinology 26:91–107
Henry JP (1992) Biological basis of the stress response. Integr Physiol Behav Sci 27:66–83
Hermsdörfer J, Marquardt C, Philipp J, Zierdt A, Nowak D, Glasauer S, Mai N (2000) Moving weightless objects: grip force control during microgravity. Exp Brain Res 132:52–64
Kirschbaum C, Prussner JC, Stone AA, Federenko I, Gaab J, Lintz D, Schommer N, Hellhammer DH (1995) Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy men. Psychosom Med 57:468–474
Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH (1996) Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci 58:1475–1483
Knopfli B, Calvert R, Bar-Or O, Villiger B, Von Duvillard SP (2001) Competition performance and basal nocturnal catecholamine excretion in cross-country skiers. Med Sci Sports Exerc 33:1228–1232
Lackner JR, DiZio P (1992) Gravitoinertial force level affects the appreciation of limb position during muscle vibration. Brain Res 592:175–180
Lackner JR, DiZio P (1996) Motor function in microgravity: movement in weightlessness. Curr Opin Neurobiol 6:744–750
Nicogossian AE, Huntoon CL, Pool SM (1994) Space physiology and medicine. Lea & Febiger, Philadelphia
Noteboom JT, Barnholt KR, Enoka RM (2001) Activation of the arousal response and impairment of performance increase with anxiety and stressor intensity. J Appl Physiol 91:2093–2101
Pozzo T, Papaxanthis C, Stapley P, Berthoz A (1998) The sensorimotor and cognitive integration of gravity. Brain Res Brain Res Rev 28:92–101
Reilly RE, Parker JF Jr (1968) Effect of heat stress and prolonged activity on perceptual-motor performance NASA-CR-1153. NASA Contract Rep NASA CR 1-51
Ross HE, Schwartz E, Emmerson P (1987) The nature of sensorimotor adaptation to altered G-levels: evidence from mass-discrimination. Aviat Space Environ Med 58(Suppl 9):A148–A152
Sangals J, Heuer H, Manzey D, Lorenz B (1999) Changed visuomotor transformations during and after prolonged microgravity. Exp Brain Res 129:378–390
Schofl C, Becker C, Prank K, von zur Muhlen A, Brabant G (1997) Twenty-four-hour rhythms of plasma catecholamines and their relation to cardiovascular parameters in healthy young men. Eur J Endocrinol 137:675–683
Schommer NC, Hellhammer DH, Kirschbaum C (2003) Dissociation between reactivity of the hypothalamus–pituitary–adrenal axis and the sympathetic–adrenal–medullary system to repeated psychosocial stress. Psychosom Med 65:450–460
Struder HK, Hollmann W, Weicker H, Schiffer T, Weber K (1999) Blood oxygen partial pressure affects plasma prolactin concentration in humans. Acta Physiol Scand 165:265–269
Thiagarajan AB, Gleiter CH, Mefford IN, Eskay RL, Nutt DJ (1989) Effect of single and repeated electroconvulsive shock on the hypothalamic-pituitary-adrenal axis and plasma catecholamines in rats. Psychopharmacology (Berl) 97:548–552
Thomas L (2000) Labor und Diagnose, Indikation und Bewertung von Laborbefunden für die medizinische Diagnostik. Frankfurt a.M., TH-Books Verlagsgesellschaft
Tuchelt H, Dekker K, Bahr V, Oelkers W (2000) Dose-response relationship between plasma ACTH and serum cortisol in the insulin-hypoglycaemia test in 25 healthy subjects and 109 patients with pituitary disease. Clin Endocrinol (Oxf) 53:301–307
Udelsman R, Holbrook NJ (1994) Endocrine and molecular responses to surgical stress. Curr Probl Surg 31:653–720
Weinberg RS, Ragan J (1978) Motor performance under three levels of trait anxiety and stress. J Mot Behav 10:169–176
Wolf OT, Schommer NC, Hellhammer DH, McEwen BS, Kirschbaum C (2001) The relationship between stress induced cortisol levels and memory differs between men and women. Psychoneuroendocrinology 26:711–720
Yen SSC (1991) Prolactin in human reproduction. In: Yen SSC, Jaffe RB (eds) Reproductive endocrinology. physiology and clinical management. Saunders, Philadelphia, pp 357–388
Zago M, Lacquaniti F (2005) Internal model of gravity for hand interception: parametric adaptation to zero-gravity visual targets on Earth. J Neurophysiol 94:1346–1357
Acknowledgments
We would like to thank the analytical team of the Institute of Cardiology and Sports Medicine, Anke Manderfeld and Astrid Hofrichter for their outstanding experience and help. Thanks to all our subjects, suffering more or less. A special thank goes to Mark Satterthwaite for doing the final edits on this manuscript. Finally we like to thank the team at NOVESPACE for giving us all the support we needed. This study was made possible by a grant of the German Space Agency (DLR) 50WB0519.
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Schneider, S., Brümmer, V., Göbel, S. et al. Parabolic flight experience is related to increased release of stress hormones. Eur J Appl Physiol 100, 301–308 (2007). https://doi.org/10.1007/s00421-007-0433-8
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DOI: https://doi.org/10.1007/s00421-007-0433-8