European Journal of Applied Physiology

, Volume 94, Issue 1–2, pp 180–187 | Cite as

A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men

  • René KoopmanEmail author
  • Ralph J. F. Manders
  • Antoine H. G. Zorenc
  • Gabby B. J. Hul
  • Harm Kuipers
  • Hans A. Keizer
  • Luc J. C. van Loon
Original Article


The aim of the present study was to determine whether a single session of resistance exercise improves whole-body insulin sensitivity in healthy men for up to 24 h. Twelve male subjects (23±1 years) were studied over a period of 4 days during which they consumed a standardized diet, providing 0.16±0.01 MJ·kg−1·day−1 containing 15±0.1 energy% (En%) protein, 29±0.1 En% fat and 55±0.3 En% carbohydrate. Insulin sensitivity was determined 24 h before and 24 h after a single resistance exercise session (8 sets of 10 repetitions at 75% of 1 repetition maximum for two leg exercise tasks) using an intravenous insulin tolerance test. Insulin sensitivity index was calculated by the decline in arterial blood glucose concentration following intravenous administration of a single bolus of human insulin (0.075 IU·kg−1 fat free mass). Basal glucose and insulin concentrations were not changed up to 24 h after the resistance exercise. However, a substantial 13±5% improvement in whole-body insulin sensitivity was observed, 24 h after the resistance exercise (P<0.05). This study shows that even a single session of resistance exercise improves whole-body insulin sensitivity for up to 24 h in healthy men, which is consistent with earlier observations following endurance exercise tasks.


Insulin tolerance test Insulin sensitivity index Resistance exercise Skeletal muscle 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • René Koopman
    • 1
    Email author
  • Ralph J. F. Manders
    • 1
  • Antoine H. G. Zorenc
    • 1
  • Gabby B. J. Hul
    • 1
  • Harm Kuipers
    • 2
  • Hans A. Keizer
    • 2
  • Luc J. C. van Loon
    • 1
    • 2
  1. 1.Departments of Human Biology, Nutrition Research Institute Maastricht (NUTRIM)Maastricht UniversityMaastrichtThe Netherlands
  2. 2.Departments of Movement Sciences, Nutrition Research Institute Maastricht (NUTRIM)Maastricht UniversityMaastrichtThe Netherlands

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