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Neuromuscular adaptations in human muscle following low intensity resistance training with vascular occlusion

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Abstract

Low-intensity (~50% of a single repetition maximum—1 RM) resistance training combined with vascular occlusion results in increases in muscle strength and cross-sectional area [Takarada et al. (2002) Eur J Appl Physiol 86:308–331]. The mechanisms responsible for this hypertrophy and strength gain remain elusive and no study has assessed the contribution of neuromuscular adaptations to these strength gains. We examined the effect of low-intensity training (8 weeks of unilateral elbow flexion at 50% 1 RM) both with (OCC) and without vascular occlusion (CON) on neuromuscular changes in the elbow flexors of eight previously untrained men [19.5 (0.4) years]. Following training, maximal voluntary dynamic strength increased (P<0.05) in OCC (22%) and CON (23%); however, isometric maximal voluntary contraction (MVC) strength increased in OCC only (8.3%, P<0.05). Motor unit activation, assessed by interpolated twitch, was high (~98%) in OCC and CON both pre- and post-training. Evoked resting twitch torque decreased 21% in OCC (P<0.05) but was not altered in CON. Training resulted in a reduction in the twitch:MVC ratio in OCC only (29%, P<0.01). Post-activation potentiation (PAP) significantly increased by 51% in OCC (P<0.05) and was not changed in CON. We conclude that low-intensity resistance training in combination with vascular occlusion produces an adequate stimulus for increasing muscle strength and causes changes in indices of neuromuscular function, such as depressed resting twitch torque and enhanced PAP.

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References

  • Aagaard P, Simonsen EB, Andersen JL, Magnusson P, Dyhre-Poulsen P (2002) Neural adaptation to resistance training: changes in evoked V-wave and H-reflex responses. J Appl Physiol 92:2309–2318

    Google Scholar 

  • Allen GM, Gandevia SC, McKenzie DK (1995) Reliability of measurements of muscle strength and voluntary activation using twitch interpolation. Muscle Nerve 18:593–600

    CAS  PubMed  Google Scholar 

  • Alway SE, MacDougall JD, Sale DG (1989) Contractile adaptations in the human triceps surae after isometric exercise. J Appl Physiol 66:2725–2732

    CAS  PubMed  Google Scholar 

  • Burgomaster KA, Moore DR, Schofield LM, Phillips SM, Sale DG, Gibala MJ (2003) Resistance training with vascular occlusion: metabolic adaptations in human muscle. Med Sci Sports Exerc 35:1203–1208

    CAS  PubMed  Google Scholar 

  • Carolan B, Cafarelli E (1992) Adaptations in coactivation after isometric resistance training. J Appl Physiol 73:911–917

    CAS  PubMed  Google Scholar 

  • Hamada T, Sale DG, MacDougall JD (2000a) Postactivation potentiation in endurance-trained male athletes. Med Sci Sports Exerc 32:403–411

    Article  CAS  PubMed  Google Scholar 

  • Hamada T, Sale DG, MacDougall JD, Tarnopolsky MA (2000b) Postactivation potentiation, fiber type, and twitch contraction time in human knee extensor muscles. J Appl Physiol 88:2131–2137

    CAS  PubMed  Google Scholar 

  • Henneman E, Somjen G, Carpenter DO (1965) Functional significance of cell size in spinal motoneurons. J Neurophysiol 28:560–580

    CAS  Google Scholar 

  • Kitai TA, Sale DG (1989) Specificity of joint angle in isometric training. Eur J Appl Physiol 58:744–748

    CAS  Google Scholar 

  • Loscher WN, Cresswell AG, Thorstensson A (1996) Central fatigue during a long-lasting submaximal contraction of the triceps surae. Exp Brain Res 108:305–314

    PubMed  Google Scholar 

  • MacDougall JD, Elder GC, Sale DG, Moroz JR, Sutton JR (1980) Effects of strength training and immobilization on human muscle fibres. Eur J Appl Physiol 43:25–34

    PubMed  Google Scholar 

  • McCall GE, Byrnes WC, Dickinson A, Pattany PM, Fleck SJ (1996) Muscle fiber hypertrophy, hyperplasia, and capillary density in college men after resistance training. J Appl Physiol 81:2004–2012

    CAS  PubMed  Google Scholar 

  • Moritani T, Sherman WM, Shibata M, Matsumoto T, Shinohara M (1992) Oxygen availability and motor unit activity in humans. Eur J Appl Physiol 64:552–556

    Google Scholar 

  • Rice CL, Cunningham DA, Paterson DH, Dickinson JR (1993) Strength training alters contractile properties of the triceps brachii in men aged 65–78 years. Eur J Appl Physiol 66:275–280

    CAS  Google Scholar 

  • Rich C, Cafarelli E (2000) Submaximal motor unit firing rates after 8 wk of isometric resistance training. Med Sci Sports Exerc 32:190–196

    CAS  PubMed  Google Scholar 

  • Rutherford OM, Jones DA (1986) The role of learning and coordination in strength training. Eur J Appl Physiol 55:100–105

    Google Scholar 

  • Sale DG, McComas AJ, MacDougall JD, Upton AR (1982) Neuromuscular adaptation in human thenar muscles following strength training and immobilization. J Appl Physiol 53:419–424

    Google Scholar 

  • Sale DG (1987) Influence of exercise and training on motor unit activation. Exerc Sport Sci Rev 15:95–151

    CAS  PubMed  Google Scholar 

  • Sale DG (2003) Neural adaptation to strength training. In Komi PV (ed) Strength and power in sport. Blackwell, Oxford, pp 281–314

  • Shinohara M, Kouzaki M, Yoshihisa T, Fukunaga T (1998) Efficacy of tourniquet ischemia for strength training with low resistance. Eur J Appl Physiol 77:189–191

    Article  CAS  Google Scholar 

  • Suzuki H, Conwit RA, Stashuk D, Santarsiero L, Metter EJ (2002) Relationships between surface-detected EMG signals and motor unit activation. Med Sci Sports Exerc 34:1509–1517

    PubMed  Google Scholar 

  • Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, Ishii N (2000) Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans. J Appl Physiol 88:2097–2106

    Google Scholar 

  • Takarada Y, Sato Y, Ishii N (2002) Effects of resistance exercise combined with vascular occlusion on muscle function in athletes. Eur J Appl Physiol 86:308–331

    Article  PubMed  Google Scholar 

  • Thorstensson A, Karlsson J, Viitasalo JH, Luhtanen P, Komi PV (1976) Effect of strength training on EMG of human skeletal muscle. Acta Physiol Scand 98:232–236

    CAS  PubMed  Google Scholar 

  • Tsunoda N, O’Hagan F, Sale DG, MacDougall JD (1993) Elbow flexion strength curves in untrained men and women and male bodybuilders. Eur J Appl Physiol 66:235–239

    CAS  Google Scholar 

  • Yao W, Fuglevand RJ, Enoka RM (2000) Motor-unit synchronization increases EMG amplitude and decreases force steadiness of simulated contractions. J Neurophysiol 83:441–452

    Google Scholar 

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Acknowledgements

This study was supported by the Natural Science and Engineering Research Council (NSERC) of Canada – both SMP and MJG. Daniel Moore is the recipient of an NSERC PGS-A scholarship. Thanks to the subjects for their time and effort. Thanks as well to Mr. John Moroz for his expert technical assistance. SMP is the recipient of a Premier’s Research Excellence Award and a CIHR New Investigator Award and acknowledges these sources of funding in the completion of this work.

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Correspondence to Stuart M. Phillips.

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Moore, D.R., Burgomaster, K.A., Schofield, L.M. et al. Neuromuscular adaptations in human muscle following low intensity resistance training with vascular occlusion. Eur J Appl Physiol 92, 399–406 (2004). https://doi.org/10.1007/s00421-004-1072-y

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