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Blood coagulation and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold

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Abstract

For rehabilitation training it is recommended that the intensity of exercise should be clearly below the individual anaerobic threshold (IAT). We investigated blood coagulation, particularly endogenous thrombin potential (ETP) and fibrinolysis following a standardized treadmill (TR) ergometer test at 90% IAT for 60–120 min. Sixteen healthy male non-smokers underwent the TR test. Blood samples were taken after a 30-min rest, immediately after exercise, and 2 h after exercise completion. Extrinsic and intrinsic total (TTPex+in) and endogenous (ETPex+in) thrombin potential, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), plasmin-α2-antiplasmin complex (PAP), D-dimer, tissue plasminogen activator antigen and activity (tPA-AG and tPA-ACT) and plasminogen activator inhibitor type 1 antigen and activity (PAI-1-AG and PAI-1-ACT) were measured. Immediately after TR, F1+2, TAT and TTPex+in were increased (P<0.05) while ETPex+in remained unchanged. In contrast, PAP, D-dimer, tPA-AG, tPA-ACT (P<0.05) were distinctly enhanced while PAI-1-ACT was decreased (P<0.05) immediately after exercise. The changes in tPA-AG, tPA-ACT, and PAI-1-ACT were reversed to nearly baseline while the enhancement in PAP and D-dimer was prolonged by more than 2 h after exercise. Long-duration exercise between 60 and 120 min controlled by IAT (90%) on a TR ergometer only implicates a small increase in thrombin generation markers and total (free and α2-macroglubulin-bound thrombin), but not in endogenous (free) thrombin potential alone. In contrast, fibrinolysis is distinctly increased after this type of exercise. Endurance exercise with an intensity below 90% IAT and a duration below 2 h generates a more favourable condition for fibrinolysis than for blood coagulation in healthy young subjects. Data are given as mean (SD).

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Acknowledgements

The authors thank Mrs. B. Tauch and Ms. Kley for their excellent technical assistance, Mrs. I. Schellenberg for her excellent measurements of TTP and ETP, and Mr. T. Noll, Dade Behring, Marburg, Germany for his support with ELISA kits. The authors declare that the experiments comply with the current laws of Germany.

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Authors and Affiliations

  1. Department of Sports Medicine, Friedrich-Schiller-University Jena, Wöllnitzerstrasse. 42, 07749, Jena, Germany

    Thomas Hilberg, Doreen Gläser, Carsten Reckhart & Holger H. W. Gabriel

  2. Centre of Vascular Biology and Medicine, Erfurt, Friedrich-Schiller-University, Jena, Germany

    Dagmar Prasa & Jörg Stürzebecher

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  1. Thomas Hilberg
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  2. Doreen Gläser
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  3. Carsten Reckhart
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  4. Dagmar Prasa
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  5. Jörg Stürzebecher
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  6. Holger H. W. Gabriel
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Correspondence to Thomas Hilberg.

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Hilberg, T., Gläser, D., Reckhart, C. et al. Blood coagulation and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold. Eur J Appl Physiol 90, 639–642 (2003). https://doi.org/10.1007/s00421-003-0907-2

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  • DOI: https://doi.org/10.1007/s00421-003-0907-2

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