European Journal of Applied Physiology

, Volume 86, Issue 3, pp 240–244

Endurance enhancement related to the human angiotensin I-converting enzyme I-D polymorphism is not due to differences in the cardiorespiratory response to training

  • D. Woods
  • M. World
  • M. Rayson
  • A. Williams
  • M. Jubb
  • Y. Jamshidi
  • M. Hayward
  • D. Mary
  • S. Humphries
  • H. Montgomery
Original Article

Abstract.

Human physical performance is strongly influenced by genetic factors. We have previously reported that the I variant of the human angiotensin I-converting enzyme (ACE) gene is associated with greater endurance performance in mountaineers and Olympic runners and improved performance in army recruits. In this study we examined whether this effect is mediated by improvements in cardiovascular fitness with training in 58 army recruits homozygous for the insertion (I, ACE genotype II) or deletion (D, ACE genotype DD) allele. A submaximal and maximal exercise protocol was used to calculate both the heart rate/oxygen uptake (\(\dot V{\rm O}_{\rm 2} \) ) relationship and changes in maximal oxygen uptake (\(\dot V{\rm O}_{{\rm 2max}} \) ), respectively. There was no significant intergroup difference in \(\dot V{\rm O}_{{\rm 2max}} \) at baseline (P=0.19) or after training (P=0.22). There was no difference between genotypes with training in the heart rate/\(\dot V{\rm O}_{\rm 2} \) elevation (P=0.79 for the mean difference in mean adjusted heart rates). However, \(\dot V{\rm O}_{\rm 2} \) at all exercise intensities in the submaximal test was lower for all subjects after training and at 80 W the reduction in \(\dot V{\rm O}_{\rm 2} \) was greater for the II subjects compared to DD subjects [mean(SEM)] [1.6  (0.27) and 0.68 (0.27) ml kg–1 min–1, respectively; P=0.02 for mean difference]. The I/D polymorphism may play a role in enhanced endurance performance but this is not mediated by differences in \(\dot V{\rm O}_{{\rm 2max}} \) or the heart rate/\(\dot V{\rm O}_{\rm 2} \) relationship in response to training.

Angiotensin I-converting enzyme genotype Exercise training 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • D. Woods
    • 1
  • M. World
    • 3
  • M. Rayson
    • 4
  • A. Williams
    • 5
  • M. Jubb
    • 3
  • Y. Jamshidi
    • 2
  • M. Hayward
    • 2
  • D. Mary
    • 6
  • S. Humphries
    • 2
  • H. Montgomery
    • 2
  1. 1.Dept Medicine, Freeman Hospital, Newcastle upon Tyne, NE7 7DNUK
  2. 2.University College London Centre for Cardiovascular Genetics, 3rd Floor Rayne Institute, 5 University Street, London WC1E 6JJUK
  3. 3.Royal Defence Medical College, Fort Blockhouse, Hampshire PO12 2ABUK
  4. 4.Optimal Performance Ltd, Old Chambers, 93–94 West Street, Farnham, Surrey GU9 7EBUK
  5. 5.Sport, Health and Exercise, Staffordshire University, Leek Road, Stoke-on-Trent, ST4 2DFUK
  6. 6.The Department of Cardiovascular Studies, Leeds University, Leeds LS2 9JTUK

Personalised recommendations