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Superoxide anion release by peripheral polymorphonuclear leukocytes in welders

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Abstract

Objectives: To investigate peripheral blood neutrophil [polymorphonuclear leukocyte (PMN)] function in a group of 23 welders compared with that in an age- and smoking habit-matched non-exposed control group. Methods: Stimulated release of superoxide anions from PMN isolated from peripheral blood of welders and of a matched group was carried out. Results: The stimulated release of superoxide anions in PMNs from welders was significantly lower (P = 0.021) than that of a control group. Smokers and older workers had a lower function of PMNs than non-smokers and younger workers. Conclusions: PMN function of welders is lower than that of controls. This effect might indicate reduced immunological defences in oxidant-exposed individuals. It is possible that PMN function might serve as a biological marker of exposure in the periodic health surveillance of welders.

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Authors and Affiliations

  1. Israel Poison Information Center, Rambam Medical Center, Haifa 31096, Israel e-mail: erica@tx.technion.ac.il, Tel.: +972-4-8543440, Fax: +972-4-8542092, , , , , , IL

    Aviva Aloufy & Erica Hoffer

  2. Occupational Health Center, Kupat Holim and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, , , , , , IL

    Yehuda Lerman

  3. Department of Epidemiology, Faculty of Medicine, Technion, Haifa, Israel, , , , , , IL

    Ada Tamir

Authors
  1. Aviva Aloufy
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  2. Yehuda Lerman
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  3. Ada Tamir
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  4. Erica Hoffer
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Received: 23 June 2000 / Accepted: 27 January 2001

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Aloufy, A., Lerman, Y., Tamir, A. et al. Superoxide anion release by peripheral polymorphonuclear leukocytes in welders. Int Arch Occup Environ Health 74, 450–453 (2001). https://doi.org/10.1007/s004200100233

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  • DOI: https://doi.org/10.1007/s004200100233

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