Abstract
Objectives
Cadmium is a ubiquitous hazardous element with nephro-toxicity after long-term exposure. The present study was initiated to examine possible effects of dietary cadmium (Cd) intake on health of local residents across Japan. For this purpose, Cd in locally harvested brown rice (Cd-BR) was taken as the parameter of Cd exposure, and two measures of mortality, i.e., standardized mortality ratio (SMR) and age-adjusted renal insufficiency mortality rate (AARIMR) were employed as parameters of over-all health effects including effects on kidney.
Methods
Japan consists of 47 prefectures. Data on Cd in 37,250 brown rice samples harvested in 1997–1998 in the 47 prefectures were made available from the Ministry of Agriculture, Forestry and Fisheries, Japan. SMR and AARIMR data (for the year 2000) by two genders in the 47 prefectures were cited from publications of the Ministry of Health, Labour and Welfare, Japan. Possible correlation of Cd in brown rice (Cd-BR) with SMR and AARIMR was examined by Poisson regression analysis.
Results
The geometric mean (GM) Cd-BR for Japan as a whole was 0.040 mg/kg with a geometric standard deviation (GSD) of 2.72. Prefectural GM values varied from a low of <0.01 mg/kg to a high of 0.089 mg/kg. Nevertheless, SMR (in a range of 89.9–119.5 for men and 87.1–111.7 for women) did not correlate with Cd-BR significantly. AARIMR (in a range of 5.3–11.9 and 3.2–8.4 for men and women, respectively) tended to decrease as a function of increasing Cd-BR both in men and women, although the correlation was insignificant in both genders.
Conclusions
No evidence was obtained in the present analysis to suggest that either mortality as a whole or the mortality due to renal failure is affected by dietary intake of Cd in rice.
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References
Arisawa K, Uemura H, Hiyoshi M, Takeda H, Saito H, Soda M (2007) Cadmium-induced renal dysfunction and mortality in two cohorts: disappearance of the association in a generation born later. Toxicol Lett 169:214–221
Elliott P, Arnold R, Cockings S, Eaton N, Järup L, Jones J, Quinn M, Rosato M, Thornton I, Toledano M, Tristan E, Wakefield J (2000) Risk of mortality, cancer incidence, and stroke in a population potentially exposed to cadmium. Occup Environ Med 57:94–97
Fukushima M (1972) Cadmium levels in various food items. Kankyo Hoken Rep 11:22–25 (in Japanese)
Ikeda M, Zhang Z-W, Shimbo S, Watanabe T, Nakatsuka H, Moon C-S, Matsuda-Inoguchi N, Higashikawa K (2000) Urban population exposure to lead and cadmium in east and south-east Asia. Sci Total Environ 249:373–384
Ikeda M, Watanabe T, Ohashi F, Shimbo S (2009) Effects of variations in cadmium and lead levels in river sediments on local foods and body burden of local residents in non-polluted areas in Japan. Biol Trac Elem Res in press doi: 10.1007/s12011-009-8436-4
International Programme on Chemical safety (1992) Environmental health criteria 134. Cadmium. World Health Organization, Geneva, pp 34–39
Ishihara T, Kobayashi E, Okubo Y, Suwazono Y, Kido T, Nishijo M, Nakagawa H, Nogawa K (2001) Association between cadmium concentration in rice and mortality in the Jinzu river basin, Japan. Toxicology 163:23–28
Joint FAO/WHO Expert Committee on Food Additives and Contaminants (JECFA) (1989) Thirty-third report of the Joint FAO/WHO Expert Committee on Food Additives and Contaminants. pp 28–31
Kasuya M, Aoshima K, Katoh T, Teranishi H, Horiguchi H, Kitagawa M, Hagino S (1992) Natural history of Itai-itai disease: a long-term observation on the clinical and laboratory findings in patients with Itai-itai disease. In: Cook ME, Morrow SA, Volpe RA (eds) Edited proceedings, Seventh International Cadmium Conference, New Orleans. Cadmium Association, London pp 180–192
Kobayashi E, Okubo Y, Suwazono Y, Kido T, Nishijo H, Nakagawa H, Nogawa K (2002) Association between total cadmium intake calculated from the cadmium in household rice and mortality among inhabitants of the cadmium-polluted Jinzu river basin of Japan. Toxicol Lett 129:85–91
Ministry of Health, Labour and Welfare, Japan (2003) Classification of diseases, injuries, and causes of death. Ministry of Health Labour and Welfare, Japan (in Japanese)
Ministry of Health, Labour and Welfare, Japan (2005) Life tables, 2005. Ministry of Health Labour and Welfare, Japan (in Japanese)
Ministry of Health, Labour and Welfare, Japan (2007a) Statistics database system: vital statistics; standard mortality ratios. Ministry of Health Labour and Welfare, Japan (in Japanese)
Ministry of Health, Labour and Welfare, Japan (2007b) Ten leading causes of death by prefecture, 2000. Ministry of Health Labour and Welfare, Japan (in Japanese)
Ministry of Health, Labour and Welfare, Japan (2008) National health and nutrition survey in Japan, 2005. Dai-ichi Shuppan Press, Tokyo (in Japanese)
Morgan H, Smart GA, Sherlock JC (1988) Intakes of metal. Sci Total Environ 75:71–100
Nakagawa H, Tabata M, Morikawa Y, Senma M, Kitagawa Y, Kawano S, Kido T (1990) High mortality and shortened life-span in patients with Itai-itai disease and subjects with suspected disease. Arch Environ Health 45:283–287
Nakagawa H, Nishijo M, Morikawa Y, Tabata M, Senma M, Kitagawa Y, Kawano S, Ishizaki M, Sugita N, Nishi M, Kido T, Nogawa K (1993) Urinary β2-microglobulin concentration and mortality in a cadmium-polluted area. Arch Environ Health 48:428–435
Philipp R (1985) Cadmium—risk assessment of an exposed residential population; a review. J R Soc Med 78:328–333
Shigematsu I, Minowa M, Usui T, Nagai M, Kitamura S, Takeuchi J, Fukushima M (1982a) Causes of mortalities of the residents in cadmium-polluted areas. Kankyo Hoken Rep 46(Part 2):1–71 (in Japanese)
Shigematsu I, Minowa M, Nagai M, Omura T, Takeuchi K (1982b) Causes of mortalities of the residents in Toyama prefecture. Kankyo Hoken Rep 48:118–138 (in Japanese)
Shimbo S, Zhang Z-W, Watanabe T, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (2001) Cadmium and lead contents in rice and other cereal products in Japan in 1998–2000. Sci Total Environ 281:165–175
Toyoda M, Matsuda R, Ikarashi A, Saito Y (1998) Estimation of daily dietary intake of environmental pollutants in Japan and analysis of the contamination routes. Food Hyg Res 48(9):43–65 (in Japanese)
Watanabe T, Nakatsuka H, Ikeda M (1989) Cadmium and lead contents in rice available in various areas of Asia. Sci Total Environ 80:175–184
Watanabe T, Shimbo S, Moon C-S, Zhang Z-W, Ikeda M (1996a) Cadmium contents in rice samples from various areas in the world. Sci Total Environ 184:191–196
Watanabe T, Nakatsuka H, Shimbo S, Iwami O, Imai Y, Moon C-S, Zhang Z-W, Iguchi H, Ikeda M (1996b) Reduced cadmium and lead burden in Japan in the past 10 years. Int Arch Occup Environ Health 68:305–314
Watanabe T, Zhang Z-W, Moon C-S, Shimbo S, Nakatsuka H, Matsuda-Inoguchi N, Higashikawa K, Ikeda M (2000) Cadmium exposure of women in general populations in Japan during 1991–1997 compared with 1977–1981. Int Arch Occup Environ Health 73:26–34
Zhang Z-W, Moon C-S, Watanabe T, Shimbo S, Ikeda M (1997) Contents of pollutant and nutrient elements in rice and wheat grown on the neighboring fields. Biol Trace Elem Res 57:39–50
Acknowledgments
Thanks are due to Plant Products Safety Division, Food safety and Consumer Affairs Bureau, Ministry of Agriculture, Forestry and Fisheries, Japan for their generous supply of Cd-BR data.
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The authors declare that they have no conflict of interest.
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Koizumi, N., Ohashi, F. & Ikeda, M. Lack of correlation between cadmium level in local brown rice and renal failure mortality among the residents: a nation-wide analysis in Japan. Int Arch Occup Environ Health 83, 333–339 (2010). https://doi.org/10.1007/s00420-009-0472-z
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DOI: https://doi.org/10.1007/s00420-009-0472-z