Histochemistry and Cell Biology

, Volume 149, Issue 4, pp 375–381 | Cite as

Biological aspects of tissue-engineered cartilage

  • Kazuto Hoshi
  • Yuko Fujihara
  • Takanori Yamawaki
  • Motohiro Harai
  • Yukiyo Asawa
  • Atsuhiko Hikita


Cartilage regenerative medicine has been progressed well, and it reaches the stage of clinical application. Among various techniques, tissue engineering, which incorporates elements of materials science, is investigated earnestly, driven by high clinical needs. The cartilage tissue engineering using a poly lactide scaffold has been exploratorily used in the treatment of cleft lip-nose patients, disclosing good clinical results during 3-year observation. However, to increase the reliability of this treatment, not only accumulation of clinical evidence on safety and usefulness of the tissue-engineered products, but also establishment of scientific background on biological mechanisms, are regarded essential. In this paper, we reviewed recent trends of cartilage tissue engineering in clinical practice, summarized experimental findings on cellular and matrix changes during the cartilage regeneration, and discussed the importance of further studies on biological aspects of tissue-engineered cartilage, especially by the histological and the morphological methods.


Cartilage Regenerative medicine Chondrocyte Tissue engineering Scaffold 



This study was supported by Grants-in-Aid for Medical Research and Development Programs Focused on Technology Transfer (AMED A-STEP, D07-05), and Research Project for Practical Applications of Regenerative Medicine (AMED).


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Sensory and Motor System Medicine, Division of Tissue Engineering, Graduate School of MedicineThe University of TokyoTokyoJapan

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