Abstract ·
Purpose: To evaluate the effect of chloroquine on experimental recurrent autoimmune melanin-protein-induced uveitis in Lewis rats. · Methods: Five Lewis rats were immunized with melanin to induce uveitis (group I); another six were immunized and treated with 5 mg/kg/day of chloroquine (group II). To reinduce uveitis, they received two booster injections of melanin. They were killed when uveitis was present after the last booster injection; every eye was evaluated by means of clinical and histopathological examination. A control group of four rats received the same chloroquine dose to evaluate retinal toxicity (group III). · Results: Rats in group I showed more severe uveitis episodes than rats in group II. The second uveitis episode was more severe in group I than in group I. Rats in group III showed no clinical or histopathological abnormalities. · Conclusions: Chloroquine decreased the severity and duration of uveitis, and in two rats it prevented recurrences. Thus, chloroquine can be considered an effective treatment for chronic, recurrent experimental uveitis.
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Received: 20 January 1998 Revised version received: 15 May 1998 Accepted: 26 May 1998
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Quiroz-Mercado, H., Cedillo-Ley, M., Rodriguez-Reyes, A. et al. Effect of chloroquine on experimental melanin-protein-induced uveitis in Lewis rats. Graefe's Arch Clin Exp Ophthalmol 237, 775–780 (1999). https://doi.org/10.1007/s004170050311
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DOI: https://doi.org/10.1007/s004170050311