Abstract
· Objective: To compare the intraocular pressure (IOP)-reducing effect of the fixed combinations of timolol 0.5% and latanoprost 0.001% or 0.005% after 4 weeks’ treatment. · Design: Following a 1-week run-in period on timolol 0.5% once daily, 139 patiens were randomized to once-daily treatment with a fixed combination of timolol 0.5% and latanoprost 0.001% (comb. 10) or latanoprost 0.005% (comp. 50) or to the individual monotherapies. The IOP was measured at inclusion and at 8 a.m., noon and 4 p.m. on days 1, 7 and 28. · Results: Comb. 10, comb. 50, latanoprost and timolol reduced IOP by 3.7, 6.1, 4.9 and 2.1 mmHg, respectively, from a baseline mean diurnal IOP (±SEM) of 24.8±0.5, 24.1±0.4, 25.2±1.2 and 24.8±0.9 mmHg, respectively. The difference in IOP reduction was significant between comb. 50 and comb. 10 (P<0.001), latanoprost (P=0.046) and timolol (P<0.001) in favor of comb. 50. There was also a significant difference between latanoprost and timolol (P=0.007), in favor of latanoprost. All treatments were generally well tolerated. · Conclusion: This study indicates that a fixed combination of latanoprost 0.005% and timolol 0.5% could be useful in the treatment of glaucoma.
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Received: 6 October 1997 Revised version received: 16 December 1997 Accepted: 7 January 1998
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Diestelhorst, M., Almegård, B. Comparison of two fixed combinations of latanoprost and timolol in open-angle glaucoma. Graefe's Arch Clin Exp Ophthalmol 236, 577–581 (1998). https://doi.org/10.1007/s004170050124
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DOI: https://doi.org/10.1007/s004170050124