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A Brillouin microscopy analysis of the crystalline lenses of Chinese adults with myopia

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Abstract

To evaluate lenticular biomechanical and geometric parameters in Chinese adults with myopia and identify relevant factors using Brillouin microscopy (BM) and Pentacam. The biomechanical and geometric properties of the ocular lenses of Chinese adults with myopia were quantified using BM. Anterior segment images were acquired using a Pentacam. Correlated factors including age, sex, spherical equivalent (SE), intraocular pressure (IOP), axial length (AL), white-to-white ratio (WTW), central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) were analyzed. We studied 65 eyes from 65 participants (mean age, 25.23 ± 6.12 years). Width of Top Plateau (WTP), Width of Bottom Plateau (WBP), Slope of Anterior Cortex (SAC), Slope of Posterior Cortex (SPC), and Height of Plateau (Height) metrics obtained using BM showed mean values of 2.597 ± 0.393 mm, 4.310 ± 0.535 mm, 1.344 ± 0.549 GPa/mm, –1.343 ± 0.480 GPa/mm, and 3.373 ± 0.048 GPa, respectively. No significant correlation was found between these parameters and sex, SE, IOP, CCT, ACA, or Height. Interestingly, WBP (r = 0.467, P < 0.001), SAC (r = 0.412, P = 0.001), and SPC (r = –0.280, P = 0.024) were significantly associated with age, and an age-related increase of WBP (slope of 35.36 ± 10.08 μm per year) was identified. Both ACD and ACV showed significant correlations with SAC (r = 0.329 and 0.380, P = 0.008 and 0.002, respectively), but not with SPC. BM provided a novel perspective on lenticular biomechanical and geometric properties in Chinese adults with myopia, which correlated with age, AL, WTW, ACD, and ACV.

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Data availability

The datasets used and analyzed during the current study are availability from the corresponding author on reasonable request.

Abbreviations

BM:

Brillouin microscopy

IOP:

Intraocular pressure

CCT:

Central corneal thickness

SE:

Spherical equivalent

WTW:

White-to-white ratio

ACD:

Anterior chamber depth

ACA:

Anterior chamber angle

AL:

Axial length

WTP:

Width of Top Plateau

WBP:

Width of Bottom Plateau

Rate:

Rate of Plateau

B-T:

Bottom-Top

SAC:

Slope of Anterior Cortex

SPC:

Slope of Posterior Cortex

Height:

Height of Plateau

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Acknowledgements

We would like to thank Editage (www.editage.cn) for English language editing.

Funding

Zhao received funding from the following sources: National Natural Science Foundation of China (Grant No. 82271119); Shanghai Rising-Star Program (23QA1401000); Healthy Young Talents Project of Shanghai Municipal Health Commission (2022YQ015); Project of Shanghai Science and Technology (Grant No.20410710100, 21Y11909800); Project of Shanghai Xuhui District Science and Technology (2020–015).

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Author notes

  1. Yong Ma and Jian Cao contributed equally to this manuscript.

Authors and Affiliations

  1. Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China

    Yong Ma, Jian Cao, Yanze Yu, Teruko Fukuyama, Yongle Bao, Xuan Ding, Lingling Niu, Xingtao Zhou & Jing Zhao

  2. Key laboratory of Myopia and Related Eye Diseases, NHC, Fudan University, Shanghai, China

    Yong Ma, Jian Cao, Yanze Yu, Teruko Fukuyama, Yongle Bao, Xuan Ding, Lingling Niu, Xingtao Zhou & Jing Zhao

  3. Key laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China

    Yong Ma, Jian Cao, Yanze Yu, Teruko Fukuyama, Yongle Bao, Xuan Ding, Lingling Niu, Xingtao Zhou & Jing Zhao

  4. Shanghai Medical College, Fudan University, Shanghai, China

    Yong Ma & Jian Cao

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  1. Yong Ma
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Contributions

Study conception and design: Xingtao Zhou AND Jing Zhao; Data acquisition: Yanze Yu AND Teruko Fukuyama; Data analysis Yong Ma AND Jian Cao; Data interpretation: Yongle Bao AND Xuan Ding AND Lingling Niu; Manuscript drafting: Yong Ma AND Jian Cao; Manuscript revision: Xingtao Zhou AND Jing Zhao; Final approval: Xingtao Zhou AND Jing Zhao. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Xingtao Zhou or Jing Zhao.

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The study was approved by the Ethics Committee Office of the Eye and ENT Hospital of Fudan University. All participants provided informed consent to participate in the study (Ethics No.: 20200530).

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Ma, Y., Cao, J., Yu, Y. et al. A Brillouin microscopy analysis of the crystalline lenses of Chinese adults with myopia. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06510-0

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