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Choroidal thickness in juvenile open angle glaucoma: insights from a south asian case–control study

  • Glaucoma
  • Published:
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Abstract

Purpose

The purpose of this study is to compare choroidal thickness in juvenile open angle glaucoma (JOAG) and healthy controls using spectral domain optical coherence tomography (SD-OCT) and study its correlations.

Methods

In this case–control study, 56 eyes of 28 JOAG patients and an equal number of controls were recruited. SD-OCT was used to measure the choroidal thickness (ChT), in the macular region at 5 locations: subfoveal, 1500 µm and 3000 µm nasal and temporal to the foveal center, and in the peripapillary region at 6 locations: up to 1500 µm, nasal and temporal to the disc, respectively. The ChT and its correlations with age, intraocular pressure, cup-to-disc ratio, central corneal thickness, mean deviation, and axial length were studied.

Results

The average macular ChT in JOAG was 306.30 ± 56.49 µm vs. 277.12 ± 64.68 µm in controls. The average peripapillary ChT in JOAG was 197.79 ± 44.05 µm vs. 187.24 ± 38.89 µm in controls. The average total ChT (p = 0.042), the average macular ChT (p = 0.022), the subfoveal ChT (p = 0.022), the ChT 1500 µm (p < 0.001), and 3000 µm temporal to the fovea (p = 0.002) were significantly thicker in the JOAG group. In the JOAG group, the average macular ChT had a significant negative correlation with age, whereas axial length was positively correlated with the average peripapillary ChT.

Conclusions

In this South Asian cohort of JOAG, the average total ChT, average macular ChT, subfoveal ChT, and ChT at 1500 µm, and 3000 µm temporal to the fovea were significantly thicker when compared to healthy controls.

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Data availability

Data sharing statement: The data for this study is available from Open Science framework with the DOI: https://doi.org/10.17605/OSF.IO/Z564W and link https://osf.io/z564w/?view_only=5d4d064cf9a844acbd38e641cdb0e85d

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Authors and Affiliations

  1. Department of Ophthalmology, Foundation University School of Health Sciences/Foundation University Islamabad/Fauji Foundation Hospital, Defence Avenue, DHA Phase-I, Islamabad 44000 Pakistan, ISLAMABAD, Islamabad, Pakistan, 44000

    Sana Nadeem

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Manuscript writing, supervision, data curation, formal analysis.

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Correspondence to Sana Nadeem.

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The Ethical Review Committee of Fauji Foundation Hospital, Rawalpindi, Pakistan granted approval for this study which is according to the Declaration of Helsinki [492/RC/FFH/RWP].

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Nadeem, S. Choroidal thickness in juvenile open angle glaucoma: insights from a south asian case–control study. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06495-w

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