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Macular hole with epiretinal proliferation: diagnostic value of en-face optical coherence tomography and clinical characteristics

  • Retinal Disorders
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Abstract

Purpose

To elucidate the clinical features and surgical outcomes of full-thickness macular hole (FTMH) with epiretinal proliferation (EP) diagnosed by both en-face and B-mode optical coherence tomography (OCT).

Method

This retrospective cohort study classified idiopathic FTMHs into two groups, based on B-scan and en-face OCT imaging: FTMH with EP (EP group) and without EP (non-EP group). The preoperative features, as well as postoperative outcomes up to 12 months, were compared between the two groups.

Result

Among 318 eyes of idiopathic FTMH that met the inclusion criteria, 59 eyes (18.6%) were in the EP group, and others were in the non-EP group. In 9 eyes (15.3%) out of the EP group, EP was not detected in the preoperative B-mode OCT but was identified through the en-face OCT. Baseline features showed a higher male proportion (47.5% vs. 27.8%, P = 0.005) and a lower incidence of vitreofoveal traction (P < 0.001) in the EP group than in the non-EP group. The EP group showed worse visual recovery than the non-EP group (− 0.23 vs. − 0.41 logarithm of the minimum angle of the resolution at 12 months, P = 0.001).

Conclusion

The en-face OCT enhances diagnostic accuracy of EP in FTMH eyes, especially in the case with smaller extent of EP. Eyes with FTMH with EP showed a worse visual recovery than FTMH without EP.

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Authors and Affiliations

  1. Department of Ophthalmology, Kyung Hee University Medial Center, Kyung Hee University, Seoul, Korea

    Jaehwan Choi

  2. Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea

    Jaehwan Choi

  3. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Sang Jin Kim, Se Woong Kang & Sungsoon Hwang

  4. Department of Ophthalmology, Chungnam National University Sejong Hospital, Sejong, Korea

    Ki Young Son

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Contributions

Concepts and design: Se Woong Kang, Jaehwan Choi. Acquisition, analysis, or interpretation of the data: Jaehwan Choi, Sungsoon Hwang, Ki Young Son. Drafting of the manuscript: Jaehwan Choi. Critical revision of the manuscript for important intellectual content: Se Woong Kang, San Jin Kim. Administration, technical, or material support: Se Woong Kang. Supervision: Se Woong Kang.

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Correspondence to Se Woong Kang.

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This research followed the tenets of the Declaration of Helsinki and was approved by Institutional Review Board (IRB) of the Samsung Medical Center, Seoul, South Korea. Informed consent was waived by the board as the research was retrospective, anonymous, and presented no threat to the rights and welfare of the research participants.

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Choi, J., Kim, S.J., Kang, S.W. et al. Macular hole with epiretinal proliferation: diagnostic value of en-face optical coherence tomography and clinical characteristics. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06446-5

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