Skip to main content

Advertisement

SpringerLink
Log in

Distribution and associations of anterior lens zonules lengths in patients with cataract

  • Cataract
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the characteristics and associations of anterior lens zonules lengths in cataract patients via ultrasound biomicroscope (UBM) measurement.

Methods

Patients with age-related cataracts and high myopic cataracts who planned to undergo cataract surgery were included in the study. After routine ophthalmic examinations, the UBM was performed on both eyes to get images of the anterior lens zonules, and Image J software was used to measure the lengths of the lens zonules. Axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and white-to-white (WTW) diameter of both eyes were obtained by IOL Master 700. Univariate and multivariate regression analyses were used to assess associated factors of anterior lens zonules lengths.

Results

Forty-nine patients with age-related cataracts and 33 patients with high myopic cataracts were enrolled. High myopic cataract patients were younger and had longer anterior lens zonules. Multivariate regression analysis showed that anterior lens zonules lengths were associated with axial lengths (temporal location: β = 0.036, P = 0.029; nasal location: β = 0.034, P = 0.011; superior location: β = 0.046, P = 0.002) and ACD (inferior location: β = 0.305, P = 0.016) in right eyes. In left eyes, anterior lens zonules lengths were associated with axial lengths (temporal location: β = 0.028, P = 0.017; inferior location: β = 0.026, P = 0.016; nasal location: β = 0.033, P < 0.001) and ACD (inferior location: β = 0.215, P = 0.030; superior location: β = 0.290, P = 0.011).

Conclusions

High myopic cataract patients have longer anterior lens zonules. AL and ACD contributed to the lengths of anterior lens zonules. Thus, for patients with long AL and deeper ACD, lens zonules measurement was crucial.

Clinical trial registration: www.chictr.org.cn identifier is ChiCTR2300071397.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Dhingra D, Thattaruthody F, Pandav SS (2019) Pseudoexfoliative zonulopathy. J Glaucoma. https://doi.org/10.1097/IJG.0000000000001373

    Article  PubMed  Google Scholar 

  2. Venkateswaran N, Henderson BA (2022) Loose zonules in cataract surgery. Curr Opin Ophthalmol 33:53–57. https://doi.org/10.1097/ICU.0000000000000826

    Article  PubMed  Google Scholar 

  3. McWhae JA, Crichton AC, Rinke M (2003) Ultrasound biomicroscopy for the assessment of zonules after ocular trauma. Ophthalmology 110:1340–1343. https://doi.org/10.1016/S0161-6420(03)00464-0

    Article  PubMed  Google Scholar 

  4. Liu X, Niu L, Zhang L, Jiang L, Liu K, Wu X, Liu X, Wang J (2023) Clinical and genetic findings in Chinese families with congenital ectopia lentis. Mol Genet Genomic Med 11:e2140. https://doi.org/10.1002/mgg3.2140

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Tran THC, Zaier D, Proenca J, Rouland JF (2020) Posterior segment intra-ocular implant (IOL) dislocation: predisposing factors, surgical management, outcome analysis. J Fr Ophtalmol 43:1062–1068. https://doi.org/10.1016/j.jfo.2020.01.018

    Article  CAS  PubMed  Google Scholar 

  6. Holladay JT, Piers PA, Koranyi G, van der Mooren M, Norrby NE (2002) A new intraocular lens design to reduce spherical aberration of pseudophakic eyes. J Refract Surg 18:683–691. https://doi.org/10.3928/1081-597X-20021101-04

    Article  PubMed  Google Scholar 

  7. Wang L, Jin G, Zhang J, Chen X, Tan X, Wang W, Ruan X, Gu X, He M, Liu Z, Luo L, Liu Y (2022) Clinically significant intraocular lens decentration and tilt in highly myopic eyes: a swept-source optical coherence tomography study. Am J Ophthalmol 235:46–55. https://doi.org/10.1016/j.ajo.2021.08.017

    Article  PubMed  Google Scholar 

  8. Fan Q, Han X, Zhu X, Cai L, Qiu X, Lu Y, Yang J (2020) Clinical characteristics of intraocular lens dislocation in Chinese Han populations. J Ophthalmol 2020:8053941. https://doi.org/10.1155/2020/8053941

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Tan W, Chen Q, Yang R, Wang Z, Zeng Q, Lei X, Jin L, Zhao S (2023) Characteristics and factors associated with the position of the haptic after ICL V4C implantation. J Cataract Refract Surg 49:416–422. https://doi.org/10.1097/j.jcrs.0000000000001134

    Article  PubMed  Google Scholar 

  10. Zhang X, Wang N, Zheng G, Liu D, Zhang Q, Lei W, Xia X, Xiong S (2023) A modified single-armed suture technique for traumatic cyclodialysis cleft with vitreoretinal injury. J Clin Med 12 DOI https://doi.org/10.3390/jcm12134252

  11. Reinstein DZ, Archer TJ, Vida RS, Piparia V, Potter JG (2022) New sizing parameters and model for predicting postoperative vault for the implantable collamer lens posterior chamber phakic intraocular lens. J Refract Surg 38:272–279. https://doi.org/10.3928/1081597X-20220302-01

    Article  PubMed  Google Scholar 

  12. Zhu Z, Zou H, Li H, Wu X, Wang Y, Li Z, Zhao Y (2023) Repeatability and reproducibility of anterior lens zonule length measurement using ArcScan insight 100 very high-frequency ultrasound. Expert Rev Med Devices 20:703–710. https://doi.org/10.1080/17434440.2023.2223967

    Article  CAS  PubMed  Google Scholar 

  13. Bassnett S (2021) Zinn’s zonule. Prog Retin Eye Res 82:100902. https://doi.org/10.1016/j.preteyeres.2020.100902

    Article  CAS  PubMed  Google Scholar 

  14. Yang S, Jiang H, Nie K, Feng L, Fan W (2021) Effect of capsular tension ring implantation on capsular stability after phacoemulsification in patients with weak zonules: a randomized controlled trial. CTR implantation in cataract patients with weak zonules. BMC Ophthalmol 21:19. https://doi.org/10.1186/s12886-020-01772-8

    Article  PubMed  PubMed Central  Google Scholar 

  15. Gu X, Zhang M, Liu Z, Ruan X, Tan X, Zhang E, Chen X, Luo L, Liu Y (2023) Building prediction models of clinically significant intraocular lens tilt and decentration for age-related cataract. J Cataract Refract Surg 49:385–391. https://doi.org/10.1097/j.jcrs.0000000000001115

    Article  PubMed  Google Scholar 

  16. Kawagoe M, Tsuruga E, Oka K, Sawa Y, Ishikawa H (2013) Matrix metalloproteinase-2 degrades fibrillin-1 and fibrillin-2 of oxytalan fibers in the human eye and periodontal ligaments in vitro. Acta Histochem Cytochem 46:153–159. https://doi.org/10.1267/ahc.13024

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Benjamin JT, van der Meer R, Im AM, Plosa EJ, Zaynagetdinov R, Burman A, Havrilla ME, Gleaves LA, Polosukhin VV, Deutsch GH, Yanagisawa H, Davidson JM, Prince LS, Young LR, Blackwell TS (2016) Epithelial-derived inflammation disrupts elastin assembly and alters saccular stage lung development. Am J Pathol 186:1786–1800. https://doi.org/10.1016/j.ajpath.2016.02.016

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Xiong W, Knispel RA, Dietz HC, Ramirez F, Baxter BT (2008) Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome. J Vasc Surg 47(166):172

    PubMed  Google Scholar 

  19. Lin HJ, Wei CC, Chang CY, Chen TH, Hsu YA, Hsieh YC, Chen HJ, Wan L (2016) Role of chronic inflammation in myopia progression: clinical evidence and experimental validation. EBioMedicine 10:269–281. https://doi.org/10.1016/j.ebiom.2016.07.021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Zhuang H, Zhang R, Shu Q, Jiang R, Chang Q, Huang X, Jiang C, Xu G (2014) Changes of TGF-beta2, MMP-2, and TIMP-2 levels in the vitreous of patients with high myopia. Graefes Arch Clin Exp Ophthalmol 252:1763–1767. https://doi.org/10.1007/s00417-014-2768-2

    Article  CAS  PubMed  Google Scholar 

  21. Atchison DA, Jones CE, Schmid KL, Pritchard N, Pope JM, Strugnell WE, Riley RA (2004) Eye shape in emmetropia and myopia. Invest Ophthalmol Vis Sci 45:3380–3386. https://doi.org/10.1167/iovs.04-0292

    Article  PubMed  Google Scholar 

  22. Park SH, Park KH, Kim JM, Choi CY (2010) Relation between axial length and ocular parameters. Ophthalmologica 224:188–193. https://doi.org/10.1159/000252982

    Article  PubMed  Google Scholar 

Download references

Funding

This study was supported by the Postdoctoral projects of Xi’an People’s Hospital (2022LBSH11).

Author information

Authors and Affiliations

  1. Xi’an People’s Hospital (Xi’an Fourth Hospital), Shaanxi Eye Hospital, Xi’an, 710004, China

    Xiaoxun Gu, Qiong Duan, Jing He, Tongtong Zhang, Li Tang & Bo Ma

Authors
  1. Xiaoxun Gu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qiong Duan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jing He
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tongtong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bo Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceptualization: all authors; methodology: XG, LT, BM; formal analysis and investigation: XG, QD, JH, TZ, LT, BM; writing—original draft preparation: XG; writing—review and editing: XG, LT, BM; funding acquisition: XG; resources: LT, BM; supervision: LT, BM.

Corresponding authors

Correspondence to Li Tang or Bo Ma.

Ethics declarations

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Xi’an People’s Hospital (Xi’an Fourth Hospital) Institutional Review Board and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gu, X., Duan, Q., He, J. et al. Distribution and associations of anterior lens zonules lengths in patients with cataract. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06379-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00417-024-06379-z

Keywords

Search

Navigation