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Outcomes of vitreoretinal surgery in eyes with retinitis pigmentosa without retinal detachment

  • Retinal Disorders
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Abstract

Purpose

Outcomes of retinal detachment (RD) have been discussed in detail in many reports of patients with retinitis pigmentosa (RP). This study tries to understand the outcomes of vitreoretinal (VR) surgery for indications other than RD in the eyes with RP.

Methods

This is a retrospective study that includes clinical data from January 2013 to December 2021. Patients with RP who were treated with a VR surgical intervention were included in the study. The primary outcome of the study was to assess the changes in best-corrected visual acuity.

Results

Forty-four eyes of 40 patients with RP were included in the study. Nearly half of the eyes (43%, 19/44) presented from 1 month to 1 year after the onset of diminished vision, with or without floaters. The mean ± standard deviation (SD) best-corrected visual acuity (BCVA) at presentation was 1.30 ± 0.79 logMAR (20/400 ± 20/125). The major surgical indications were vitreous opacities (43.2%, 19/44) and subluxated/dislocated cataractous lenses (25%, 11/44). The median follow-up duration was 8 months (interquartile range (IQR): 1.5–27). Approximately 77% (34/44) of the eyes had improvement in vision. The mean postoperative BCVA at the last follow-up was 0.95 ± 0.73 logMAR (p-value: 0.03).

Conclusions

Most eyes with RP recovered well after VR surgical interventions, with short-term improvements in visual acuity. It may be crucial to address the vitreous opacities and membranes as they hinder the residual central island of vision in RP. However, appropriate counselling is required regarding the progressive nature of retinal neuronal degeneration.

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Funding

This study was supported by the Hyderabad Eye Research Foundation, Hyderabad, India.

Author information

Authors and Affiliations

  1. Srimati Kanuri Santhamma Center for Vitreoretinal Diseases, Anant Bajaj Retina Institute, Kallam Anji Reddy Campus, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad, Telangana, 500 034, India

    Abhishek Upadhyaya, Hardik Kiri, Saarang Hansraj, Brijesh Takkar, Subhadra Jalali & Deepika C. Parameswarappa

  2. Standard Chartered – LVPEI Academy for Eye Care Education, L V Prasad Eye Institute, Hyderabad, Telangana, India

    Abhishek Upadhyaya, Hardik Kiri & Saarang Hansraj

  3. Department of Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, Telangana, India

    Ramya Natarajan

  4. Vitreoretina and Uveitis Services, Anant Bajaj Retina Institute, Mithu Tulasi Chanrai Campus, L V Prasad Eye Institute, Bhubaneswar, India

    Srikanta Kumar Padhy & Tapas Ranjan Padhi

  5. Indian Health Outcomes, Public Health, and Economics Research Center, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, Telangana, India

    Brijesh Takkar

Authors
  1. Abhishek Upadhyaya
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  2. Hardik Kiri
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  3. Ramya Natarajan
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  4. Saarang Hansraj
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  5. Srikanta Kumar Padhy
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  6. Brijesh Takkar
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  7. Tapas Ranjan Padhi
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  8. Subhadra Jalali
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  9. Deepika C. Parameswarappa
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Corresponding author

Correspondence to Deepika C. Parameswarappa.

Ethics declarations

Ethics approval

All procedures performed in this study that involved human participants were in accordance with the ethical standards of LV Prasad Eye Institute (Ethics Reference No. LEC-XXX-R-09–20-505) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all the participants regarding publishing the information.

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All authors declare no competing interests.

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Upadhyaya, A., Kiri, H., Natarajan, R. et al. Outcomes of vitreoretinal surgery in eyes with retinitis pigmentosa without retinal detachment. Graefes Arch Clin Exp Ophthalmol 262, 441–448 (2024). https://doi.org/10.1007/s00417-023-06274-z

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  • DOI: https://doi.org/10.1007/s00417-023-06274-z

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