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Increased risk of glaucoma development in patients with central serous chorioretinopathy: results of a 11-year population-based cohort study

  • Retinal Disorders
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Abstract

Purpose

To investigate whether patients with central serous chorioretinopathy (CSC) have increased risk of developing glaucoma.

Methods

Patients diagnosed with CSC between 1 January 2008 and 31 December 2018 were included in this study using data from the Taiwanese National Health Insurance Research Database (NHIRD). The CSC cohort was matched with a non-CSC cohort using the propensity score matching method, based on sex, age (in 10-year intervals), index date year, comorbidities, and steroid use, resulting in equal numbers of patients in both cohorts. Patients were followed up until 31 December 2019 or until they were withdrawn from the NHIRD. The incidence of glaucoma was compared between the two cohorts using the Cox regression model, and the risk of developing glaucoma was estimated using the Kaplan–Meier method.

Results

After adjusting for sex, age, comorbidities, and steroid use, the CSC cohort showed a significantly higher risk of developing glaucoma compared to those without CSC (adjusted HR = 3.99; 95% CI = 3.44–4.62). The cumulative incidence of glaucoma in the CSC cohort was also significantly higher than in the non-CSC cohort (log-rank test, p < 0.001). Among the glaucoma subtypes, normal tension glaucoma had the highest risk (adjusted HR = 5.79; 95% CI = 3.41–9.85), followed by primary open-angle glaucoma (adjusted HR = 2.77; 95% CI = 2.12–3.62).

Conclusions

In conclusion, our study shows that CSC patients are at a higher risk of developing glaucoma, especially NTG. Awareness and regular glaucoma screenings are essential for patients with CSC.

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Acknowledgements

We are grateful to Health Data Science Center, China Medical University Hospital for providing administrative, technical, and funding support.

Funding

This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW111-TDU-B-212–134004), China Medical University Hospital (DMR-111–105). The funders had no role in the study design, data collection and analysis, the decision to publish, or preparation of the manuscript. No additional external funding was received for this study.

Author information

Authors and Affiliations

  1. Eye Center, China Medical University Hospital, Taichung, 40402, Taiwan

    Yu-Te Huang, Jamie Jiin-Yi Chen, Ming-Yen Wu, Hui-Ju Lin & Peng-Tai Tien

  2. School of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan

    Lei Wan, Fuu-Jen Tsai & Hui-Ju Lin

  3. Department of Obstetrics and Gynecology, China Medical University, Taichung, Taiwan

    Lei Wan

  4. School of Pharmacy, China Medical University, Taichung, Taiwan

    Yih-Dih Cheng

  5. Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan

    Yih-Dih Cheng

  6. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

    Teng-Shun Yu & Yu-Tung Hung

  7. Department of General Medicine, Medical University of Lublin, Bangkok, Thailand

    Kewalee Rujikajorn

  8. Department of Medical Research, China Medical University Hospital, Taichung, 40402, Taiwan

    Fuu-Jen Tsai

  9. School of Medicine, College of Medicine, China Medical University, Taichung, 40402, Taiwan

    Peng-Tai Tien

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  1. Yu-Te Huang
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Corresponding authors

Correspondence to Hui-Ju Lin or Peng-Tai Tien.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the China Medical University Hospital Research Ethics Committee (CMUH110-REC3-133) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Owing to the retrospective design of the study and the use of deidentified patient information, the review board waived the need for written informed consent.

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Huang, YT., Wan, L., Cheng, YD. et al. Increased risk of glaucoma development in patients with central serous chorioretinopathy: results of a 11-year population-based cohort study. Graefes Arch Clin Exp Ophthalmol 261, 3457–3464 (2023). https://doi.org/10.1007/s00417-023-06201-2

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