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Evaluation of scleral thickness in patients with Fuchs endothelial dystrophy

  • Cornea
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Abstract

Purpose

To evaluate scleral thickness using anterior segment-optical coherence tomography (AS-OCT) in Fuchs endothelial dystrophy (FED) and compare the results with healthy individuals.

Methods

Thirty-two eyes of 32 patients with FED and 30 eyes of 30 age, gender, spherical equivalent and axial length matched healthy participants were included. All subjects underwent a detailed ophthalmological examination including endothelial cell density and central corneal thickness (CCT) measurements. Scleral thickness was measured by AS-OCT (Swept Source-OCT, Triton,Topcon,Japan) in 4 quadrants (superior, inferior, nasal, temporal) from 6 mm posterior to the scleral spur.

Results

The mean ages were 62.5 ± 13.2 (33–81) for FED group; 64 ± 8.1 (48–81) for control group. CCT was significantly greater in FED group than in the control group (586.8 ± 33.1 (514–635) vs 545.0 ± 20.7 (503–587), respectively)(p = 0.000). In FED group, mean scleral thickness in the superior, inferior, nasal and temporal quadrants were 434.0 ± 30.6 (371–498), 442.8 ± 27.6 (395–502), 447.7 ± 31.4 (382–502), 443.4 ± 30.3 (386–504) μm, respectively. In control group, the mean scleral thickness in the superior, inferior, nasal and temporal quadrants were 381.3 ± 20.0 (341–436), 383.2 ± 16.0 (352–436), 389.2 ± 21.0 (353–440), 383.2 ± 19.2 (349–440) µm, respectively. The mean scleral thickness was significantly higher in all quadrants in FED group than in control group (p = 0.000).

Conclusion

In patients with FED, scleral thickness was significantly higher. FED is a progressive corneal disease that results in the accumulation of extracellular material in the cornea. These findings suggest that the accumulation of extracellular deposits may not be limited to the cornea. Due to their functional similarity and anatomical proximity, sclera may also be affected in FED.

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Funding

No funding was received for this research.

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Authors and Affiliations

  1. Department of Ophthalmology, Ege University, Izmir, Turkey

    Ilayda Korkmaz, Cumali Degirmenci, Ozlem Barut Selver & Melis Palamar

  2. Department of Ophthalmology, Ege University, Bornova, 35100, Izmir, Turkey

    Melis Palamar

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  1. Ilayda Korkmaz
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  2. Cumali Degirmenci
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  3. Ozlem Barut Selver
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  4. Melis Palamar
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Corresponding author

Correspondence to Melis Palamar.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ege University Committee of Ethics (Project number: 21–12.1 T/29) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Korkmaz, I., Degirmenci, C., Selver, O.B. et al. Evaluation of scleral thickness in patients with Fuchs endothelial dystrophy. Graefes Arch Clin Exp Ophthalmol 261, 2883–2889 (2023). https://doi.org/10.1007/s00417-023-06107-z

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  • DOI: https://doi.org/10.1007/s00417-023-06107-z

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