Skip to main content

Advertisement

SpringerLink
Log in

Comparing internal versus external carotid artery branch delivery of intraarterial chemotherapy for the treatment of retinoblastoma

  • Oncology
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

  • 1 Altmetric

Abstract

Purpose

The goal of this study was to compare the efficacy of intraarterial chemotherapy (IAC) for retinoblastoma delivered via the ophthalmic artery (OA) division of the internal carotid artery (ICA) versus alternative branches of the external carotid artery (ECA).

Methods

We performed a retrospective chart review of patients receiving IAC for retinoblastoma at a single institution. Subjects were divided into three groups: those that received IAC solely through the OA branch of the ICA, those that initially received IAC through the OA branch of the ICA but were later switched to the ECA, and those that only received IAC through the ECA. The main outcomes compared included globe salvage rate and reduction in tumor thickness and size.

Results

A total of 30 eyes from 26 patients were included. A total of 91 (58%) sessions of IAC were performed through the OA division of the ICA and 65 (42%) were performed through branches of the ECA. Eleven eyes (37%) solely received IAC through the OA branch of the ICA, 16 eyes (53%) were converted to ECA treatment, and 3 eyes solely received IAC through branches of the ECA. Statistical analysis did not show any significant difference in globe salvage rate or reduction in tumor thickness and size.

Conclusion

The use of alternative approaches for IAC when the OA branch of the ICA catheterization is not feasible allows for safe continued delivery of highly effective IAC, leading to similar outcomes in terms of globe salvage and reduction in tumor size.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Gobin YP, Dunkel IJ, Marr BP et al (2011) Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol Chic Ill 1960 129:732–737. https://doi.org/10.1001/archophthalmol.2011.5

    Article  Google Scholar 

  2. Manjandavida F, Stathopoulos C, Zhang J et al (2019) Intra-arterial chemotherapy in retinoblastoma – a paradigm change. Indian J Ophthalmol 67:740–754. http://dx.doi.org.proxy.lib.umich.edu/10.4103/ijo.IJO_866_19

  3. Yamane T, Kaneko A, Mohri M (2004) The technique of ophthalmic arterial infusion therapy for patients with intraocular retinoblastoma. Int J Clin Oncol 9:69–73. https://doi.org/10.1007/s10147-004-0392-6

    Article  PubMed  Google Scholar 

  4. Shields CL, Shields JA (2010) Intra-arterial chemotherapy for retinoblastoma: the beginning of a long journey. Clin Experiment Ophthalmol 38:638–643. https://doi.org/10.1111/j.1442-9071.2010.02297.x

    Article  PubMed  Google Scholar 

  5. Bertelli E, Leonini S, Galimberti D et al (2016) Hemodynamic and anatomic variations require an adaptable approach during intra-arterial chemotherapy for intraocular retinoblastoma: alternative routes, strategies, and follow-up. Am J Neuroradiol 37:1289–1295. https://doi.org/10.3174/ajnr.A4741

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Quinn C, Tummala R, Anderson J et al (2019) Effectiveness of alternative routes of intra-arterial chemotherapy administration for retinoblastoma: potential for response and complications. Interv Neuroradiol J Peritherapeutic Neuroradiol Surg Proced Relat Neurosci 25:556–561. https://doi.org/10.1177/1591019919831953

    Article  Google Scholar 

  7. Sweid A, Hammoud B, Texakalidis P et al (2020) The use of alternative routes for the delivery of intra-arterial chemotherapy for retinoblastoma. Neurosurgery 87:956–963. https://doi.org/10.1093/neuros/nyaa142

    Article  PubMed  Google Scholar 

  8. Shields CL, Mashayekhi A, Au AK et al (2006) The International Classification of Retinoblastoma predicts chemoreduction success. Ophthalmology 113:2276–2280. https://doi.org/10.1016/j.ophtha.2006.06.018

    Article  PubMed  Google Scholar 

  9. Abramson DH, Fabius AWM, Issa R et al (2015) Advanced unilateral retinoblastoma: the impact of ophthalmic artery chemosurgery on enucleation rate and patient survival at MSKCC. PloS One 10:e0145436. https://doi.org/10.1371/journal.pone.0145436

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Munier FL, Mosimann P, Puccinelli F et al (2017) First-line intra-arterial versus intravenous chemotherapy in unilateral sporadic group D retinoblastoma: evidence of better visual outcomes, ocular survival and shorter time to success with intra-arterial delivery from retrospective review of 20 years of treatment. Br J Ophthalmol 101:1086–1093. https://doi.org/10.1136/bjophthalmol-2016-309298

    Article  PubMed  Google Scholar 

  11. Abramson DH, Marr BP, Dunkel IJ et al (2012) Intra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-year results. Br J Ophthalmol 96:499–502. https://doi.org/10.1136/bjophthalmol-2011-300498

    Article  PubMed  Google Scholar 

  12. Chen M, Jiang H, Zhang J et al (2017) Outcome of intra-arterial chemotherapy for retinoblastoma and its influencing factors: a retrospective study. Acta Ophthalmol (Copenh) 95:613–618. https://doi.org/10.1111/aos.13333

    Article  CAS  Google Scholar 

  13. Chen Q, Zhang B, Dong Y et al (2019) Intra-arterial chemotherapy as primary or secondary treatment for infants diagnosed with advanced retinoblastoma before 3 months of age. BMC Cancer 19:693. https://doi.org/10.1186/s12885-019-5844-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Shields CL, Manjandavida FP, Lally SE et al (2014) Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the International Classification of Retinoblastoma. Ophthalmology 121:1453–1460. https://doi.org/10.1016/j.ophtha.2014.01.026

    Article  PubMed  Google Scholar 

  15. Jia S, Wen X, Zhou M et al (2021) Comparison of intra-arterial chemotherapy efficacy delivered through the ophthalmic artery or external carotid artery in a cohort of retinoblastoma patients. Front Med 8

  16. Kaliki S, Srinivasan V, Gupta A et al (2015) Clinical features predictive of high-risk retinoblastoma in 403 Asian Indian patients: a case-control study. Ophthalmology 122:1165–1172. https://doi.org/10.1016/j.ophtha.2015.01.018

    Article  PubMed  Google Scholar 

  17. Biewald EM, Bornfeld N, Metz KA et al (2020) Histopathology of retinoblastoma eyes enucleated after intra-arterial chemotherapy. Br J Ophthalmol 104:1171–1175. https://doi.org/10.1136/bjophthalmol-2019-315209

    Article  PubMed  Google Scholar 

  18. Sweid A, El Naamani K, Sajja KC et al (2020) Incidence and predictors of ophthalmic artery occlusion in intra-arterial chemotherapy for retinoblastoma. J Neurointerventional Surg. https://doi.org/10.1136/neurintsurg-2020-016759

    Article  Google Scholar 

  19. Batu Oto B, Sarıcı AM, Kızılkılıç O (2020) Superselective intra-arterial chemotherapy treatment for retinoblastoma: clinical experience from a tertiary referral centre. Can J Ophthalmol J Can Ophtalmol 55:406–412. https://doi.org/10.1016/j.jcjo.2020.04.009

    Article  Google Scholar 

  20. Rojanaporn D, Chanthanaphak E, Boonyaopas R et al (2019) Intra-arterial chemotherapy for retinoblastoma: 8-year experience from a tertiary referral institute in Thailand. Asia-Pac J Ophthalmol Phila Pa 8:211–217. https://doi.org/10.22608/APO.2018294

    Article  CAS  Google Scholar 

  21. Pekacka A (2020) The role of intraarterial chemotherapy in the management of retinoblastoma. J Ophthalmol 2020:3638410. https://doi.org/10.1155/2020/3638410

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Shields CL, Mashayekhi A, Cater J et al (2004) Chemoreduction for retinoblastoma. Analysis of tumor control and risks for recurrence in 457 tumors. Am J Ophthalmol 138:329–337. https://doi.org/10.1016/j.ajo.2004.04.032

    Article  PubMed  Google Scholar 

  23. Wyse E, Handa JT, Friedman AD, Pearl MS (2016) A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma. Pediatr Radiol 46:1223–1233. https://doi.org/10.1007/s00247-016-3554-6

    Article  PubMed  Google Scholar 

Download references

Funding

This study was funded by the Richard N. and Marilyn K. Witham Professorship.

Author information

Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, 1000 Wall St, Ann Arbor, MI, USA

    Emily Chang, Yunshu Zhou, David Musch & Hakan Demirci

  2. Department of Epidemiology, University of Michigan, Ann Arbor, USA

    David Musch

  3. Department of Pediatrics, Division of Hematology and Oncology, University of Michigan, Ann Arbor, USA

    Amy Edmonds, Laura Sedig & Raymond Hutchinson

  4. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Neeraj Chaudhary

  5. Department of Radiology, University of Michigan, Ann Arbor, MI, USA

    Neeraj Chaudhary

Authors
  1. Emily Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yunshu Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Musch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Amy Edmonds
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Laura Sedig
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Raymond Hutchinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Neeraj Chaudhary
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hakan Demirci
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hakan Demirci.

Ethics declarations

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the University of Michigan and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (PDF 72 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chang, E., Zhou, Y., Musch, D. et al. Comparing internal versus external carotid artery branch delivery of intraarterial chemotherapy for the treatment of retinoblastoma. Graefes Arch Clin Exp Ophthalmol 261, 2679–2687 (2023). https://doi.org/10.1007/s00417-023-06037-w

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-023-06037-w

Keywords

Search

Navigation