Skip to main content


Log in

The course of non-infectious uveitis in pregnancy: a retrospective study of 79 pregnancies

  • Inflammatory Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript



The study aims to describe the course and management of non-infectious uveitis during pregnancy and postpartum period in European populations.


A retrospective observational study in two tertiary centers in France was performed. Pregnant patients during the follow-up of a non-infectious uveitis as well as those with new-onset uveitis were included. The medical records were analyzed with a systematic collection of the characteristics of the uveitis, the treatment and evolution of the uveitis, and the course of the pregnancy including obstetric complications.


Seventy-nine pregnancies in 59 women were included: 48 patients (68 pregnancies) were followed for uveitis and 11 had a new-onset uveitis diagnosis. Most patients had idiopathic uveitis (32.2%) or sarcoid uveitis (27.1%). Among the patients followed for uveitis at the time of conception, there were 18 relapses (26.5%) requiring treatment escalation. Relapses occurred mainly in the two first trimester (n = 12) or during the postpartum period (n = 5) and were significantly associated with an active uveitis at the time of conception (OR = 9.2, 95% CI [1.57–48.4], p = 0.01). The characteristics of the new-onset uveitis were similar to those already existing before pregnancy. Obstetric complications occurred in 25 pregnancies (31.6%), mainly gestational hypertension and gestational diabetes.


The frequency of non-infectious uveitis relapses decreases as pregnancy progresses, in agreement with data from other non-European studies. However, multidisciplinary monitoring should be advised, especially to uncontrolled patients at the time of conception.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others


  1. Bertrand P-J, Jamilloux Y, Ecochard R et al (2019) Uveitis: autoimmunity and beyond. Autoimmun Rev 18:102351.

    Article  PubMed  Google Scholar 

  2. Tsirouki T, Dastiridou A, Symeonidis C et al (2018) A focus on the epidemiology of uveitis. Ocul Immunol Inflamm 26:2–16.

    Article  PubMed  Google Scholar 

  3. Gritz DC, Wong IG (2004) Incidence and prevalence of uveitis in Northern California; the Northern California Epidemiology of Uveitis Study. Ophthalmol 111:491–500.

    Article  Google Scholar 

  4. Borchers AT, Naguwa SM, Keen CL, Gershwin ME (2010) The implications of autoimmunity and pregnancy. J Autoimmun 34:J287-299.

    Article  CAS  PubMed  Google Scholar 

  5. Kump LI, Cervantes-Castañeda RA, Androudi SN et al (2006) Patterns of exacerbations of chronic non-infectious uveitis in pregnancy and puerperium. Ocul Immunol Inflamm 14:99–104.

    Article  PubMed  Google Scholar 

  6. Rabiah PK, Vitale AT (2003) Noninfectious uveitis and pregnancy. Am J Ophthalmol 136:91–98.

    Article  PubMed  Google Scholar 

  7. Chiam NPY, Hall AJH, Stawell RJ et al (2013) The course of uveitis in pregnancy and postpartum. Br J Ophthalmol 97:1284–1288.

    Article  PubMed  Google Scholar 

  8. Grotting LA, Papaliodis GN (2017) A review of the course and treatment of non-infectious uveitis during pregnancy. Semin Ophthalmol 32:75–81.

    Article  PubMed  Google Scholar 

  9. Standardization of Uveitis Nomenclature (SUN) Working Group (2021) Development of classification criteria for the uveitides. Am J Ophthalmol 228:96–105.

    Article  Google Scholar 

  10. de Parisot A, Kodjikian L, Errera M-H et al (2017) Randomized controlled trial evaluating a standardized strategy for uveitis etiologic diagnosis (ULISSE). Am J Ophthalmol 178:176–185.

    Article  PubMed  Google Scholar 

  11. Mochizuki M, Smith JR, Takase H et al (2019) Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of ocular sarcoidosis. Br J Ophthalmol 103:1418–1422.

    Article  PubMed  Google Scholar 

  12. Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature (SUN) Working Group (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 140:509–516.

    Article  Google Scholar 

  13. Verhagen FH, Braakenburg AM, Kremer T et al (2017) Reduced number of relapses of human leucocyte antigen-B27-associated uveitis during pregnancy. Acta Ophthalmol 95:e798–e799.

    Article  PubMed  Google Scholar 

  14. Chiam NPY, Lim LLP (2014) Uveitis and gender: the course of uveitis in pregnancy. J Ophthalmol 2014:401915.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Sharon Y, Adler A, Tiosano A, et al (2022) The effect of pregnancy on the course of uveitis in single and multiple pregnancies. Graefes Arch ClinExp Ophthalmol.

  16. Idiopathic multifocal choroiditis and punctate inner choroidopathy: an evaluation in pregnancy — PubMed. Accessed 19 Apr 2022

  17. Burmester GR, Landewé R, Genovese MC et al (2017) Adalimumab long-term safety: infections, vaccination response and pregnancy outcomes in patients with rheumatoid arthritis. Ann Rheum Dis 76:414–417.

    Article  PubMed  Google Scholar 

  18. Prieto-Peña D, Calderón-Goercke M, Adán A et al (2021) Efficacy and safety of certolizumab pegol in pregnant women with uveitis. Recommendations on the management with immunosuppressive and biologic therapies in uveitis during pregnancy. Clin Exp Rheumatol 39:105–114

    Article  PubMed  Google Scholar 

  19. Mariette X, Förger F, Abraham B et al (2018) Lack of placental transfer of certolizumab pegol during pregnancy: results from CRIB, a prospective, postmarketing, pharmacokinetic study. Ann Rheum Dis 77:228–233.

    Article  CAS  PubMed  Google Scholar 

  20. Götestam Skorpen C, Hoeltzenbein M, Tincani A et al (2016) The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis 75:795–810.

    Article  CAS  PubMed  Google Scholar 

  21. Boucheron P, Lailler G, Moutengou E, et al (2021) Hypertensive disorders of pregnancy and onset of chronic hypertension in France: the nationwide CONCEPTION study. Eur Heart J ehab686

  22. Billionnet C, Mitanchez D, Weill A et al (2017) Gestational diabetes and adverse perinatal outcomes from 716,152 births in France in 2012. Diabetologia 60:636–644.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Chapelon Abric C, Ginsburg C, Biousse V et al (1998) Sarcoidosis and pregnancy. A retrospective study of 11 cases. Rev Med Interne 19:305–312.

    Article  CAS  PubMed  Google Scholar 

  24. Kobak S (2020) Regression of sarcoidosis during pregnancy: case report and review of the literature. Mediterr J Rheumatol 31:416–420.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Mayock RL, Sullivan RD, Greening RR, Jones R (1957) Sarcoidosis and pregnancy. J Am Med Assoc 164:158–163.

    Article  CAS  PubMed  Google Scholar 

  26. Hadid V, Patenaude V, Oddy L, Abenhaim HA (2015) Sarcoidosis and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 7 million births. J Perinat Med 43:201–207.

    Article  PubMed  Google Scholar 

  27. Köcher L, Rossides M, Remaeus K et al (2020) Maternal and infant outcomes in sarcoidosis pregnancy: a Swedish population-based cohort study of first births. Respir Res 21:225.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations



S. G. and P. S. were the principal investigators; they conceived and designed the study. S. G. collected the data. All authors interpreted the data and approved the manuscript. S. G. and P. S. drafted the manuscript. All authors reviewed the manuscript.

Corresponding author

Correspondence to S. Giorgiutti.

Ethics declarations

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Comité de Protection des Personnes Sud Est IV and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The present study received approval from the local ethics committee (CPP Sud Est IV) on February 2019 (N° 19–31) and was registered on (NCT 03863782).

Informed consent

According to French law, written consent for this study was not required due to its retrospective nature.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Giorgiutti, S., Jamilloux, Y., Gerfaud-Valentin, M. et al. The course of non-infectious uveitis in pregnancy: a retrospective study of 79 pregnancies. Graefes Arch Clin Exp Ophthalmol 261, 1391–1398 (2023).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: