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Development of the selective micropulse individual retinal therapy depends on age and type on the Fitzpatrick scale

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To develop a selective micropulse individual retinal therapy (SMIRT) based on the age and appearance type of the patient, to derive a formula for calculating power, and evaluate clinical efficacy for the treatment of central serous chorioretinopathy (CSCR).

Methods

73 patients (aged 30–65 years) with acute CSCR and types 1–4 on the Fitzpatrick scale were divided into 2 groups. In the first group (33 patients), the testing of the micropulse mode (50 µs, 2.4%, 10 ms, 100 µm, 0.4–1.9 W) on the Navilas 577 s laser system defined as selective by computer modeling was performed. A logistic regression function based on probability damage detection (PDD) of the 1584 laser spots from power, age, and type on the Fitzpatrick scale was constructed. PDD is the probability of detecting the laser spots using the autofluorescence method. The second group was divided into 4 subgroups of 10 eyes each. Groups 2.1, 2.2, and 2.3 were treated without preliminary testing. The power for Groups 2.1, 2.2, and 2.3 was obtained with the inverse PDD function, so that PDD was 50%, 70%, and 90%, respectively. Control group 2.4 went without treatment.

Results

The transmission and absorption coefficients of laser radiation of the eye depend on the age and the Fitzpatrick scale type. In Groups 2.1–2.3, complete resorption of subretinal fluid was observed 3 months after CSCR treatment in 5 (P < 0.35), 8 (P < 0.023), and 10 eyes (P < 0.0008) out of 10, respectively.

Conclusion

The developed SMIRT is effective for CSCR treatment with PDD 90%.

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Authors and Affiliations

  1. Laser Retinal Surgery Department, The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russia

    Elena V. Ivanova & Pavel L. Volodin

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  1. Elena V. Ivanova
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  2. Pavel L. Volodin
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Corresponding author

Correspondence to Elena V. Ivanova.

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Ethical approval

All procedures performed in this study were in accordance with the tenets of the Declaration of Helsinki 1964 and its amendments. This study was approved by the Institutional Review Board: Interuniversity Ethics Committee (Protocol 11).

Informed consent

All patients provided written consent and were informed of the surgical procedures beforehand, including the testing phase that was performed to determine the personalized parameters for the treatment.

Conflict of interest

The authors declare no competing interests.

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Presented virtually at the Association for Research in Vision and Ophthalmology (ARVO) May 2-6, 2021, San Francisco, CA, USA .

This article received support from the mentorship team. Further information can be found in the editorial https://link.springer.com/article/10.1007/s00417-019-04518-5.

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Ivanova, E.V., Volodin, P.L. Development of the selective micropulse individual retinal therapy depends on age and type on the Fitzpatrick scale. Graefes Arch Clin Exp Ophthalmol 261, 381–390 (2023). https://doi.org/10.1007/s00417-022-05800-9

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  • DOI: https://doi.org/10.1007/s00417-022-05800-9

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