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Orbital solitary fibrous tumours: clinicopathological characteristics and recurrence prediction

  • Oncology
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Abstract

Background

SFTs are thought to have an unpredictable clinical course and currently have no recognized prognostic criterion. Our study aimed to determine the relationship between clinicopathological characteristics and the prognosis of patients with orbital SFTs.

Methods

The clinicopathological features of these patients were extracted from clinical records. The relationships between these features and prognosis were analysed.

Results

The positive rates of CD34, CD99, Blc2, and STAT6 expression were 90.3%, 90.3%, 83.9%, and 100%, respectively. The tumour recurrence rate was 38.7%. A higher recurrence rate was observed in patients with Ki67 index ≥ 5 (56.25% vs. 20%, P = 0.038).

Conclusion

A Ki67 index ≥ 5 was an effective parameter for predicting tumour recurrence of orbital SFTs. Close follow-up is needed for these patients.

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Acknowledgements

We give thanks to all patients included in our study.

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Authors and Affiliations

  1. Department of Ophthalmology, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, China

    Xiao-jin Gao, Xiao-lin Peng, Yu-jiao Wang & Wei-min He

  2. Department of Ophthalmology, Chengdu First People’s Hospital, Chengdu, China

    Xiao-jin Gao

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  1. Xiao-jin Gao
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Contributions

Xiao-jin Gao and Wei-min He wrote the main manuscript text. Xiao-jin Gao and Xiao-lin Peng collected clinical data. Xiao-lin Peng and Yu-jiao Wang analysed these data. Wei-min He designed this research.

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Correspondence to Wei-min He.

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Gao, Xj., Peng, Xl., Wang, Yj. et al. Orbital solitary fibrous tumours: clinicopathological characteristics and recurrence prediction. Graefes Arch Clin Exp Ophthalmol 261, 223–231 (2023). https://doi.org/10.1007/s00417-022-05795-3

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